anti-Porcupine Homolog (Drosophila) (PORCN) Antibodies

PORCN belongs to the evolutionarily conserved porcupine (Porc) gene family. Additionally we are shipping Porcupine Homolog (Drosophila) Kits (6) and Porcupine Homolog (Drosophila) Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PORCN 64840 Q9H237
PORCN 53627 Q9JJJ7
PORCN 317368  
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Top anti-Porcupine Homolog (Drosophila) Antibodies at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-PORCN Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PORCN Antibody  Positive Control: Lane1: 50ug PORCN-KO HT1080 (microsomes), Lane2: 50ug HT1080 (microsomes), Lane3: 50ug PORCN transfected HT1080 (microsomes)  Primary Antibody Dilution :  1:500 Secondary Antibody :  Anti-rabbit-HRP  Secondry Antibody Dilution :  1:10,000 Submitted by: Anonymous WB Suggested Anti-Porcn Antibody Titration: 1.0 ug/ml Positive Control: Mouse Thymus 100 μL Log in to see 2 to 3 Days
$289.00
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated IP, WB Immunoprecipitation of PORCN transfected lysate using anti-PORCN MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with . Western Blot analysis of PORCN expression in transfected 293T cell line by PORCN MaxPab polyclonal antibody.Lane 1: PORCN transfected lysate(51 KDa).Lane 2: Non-transfected lysate. 100 μL Log in to see 11 to 12 Days
$418.57
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemistry-Paraffin: PORCN Antibody  - Immunohistochemical staining of human adrenal gland shows moderate cytoplasmic positivity in glandular cells. 100 μL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: PORCN Antibody [NBP1-59677] - Sample Tissue: Hela Whole cell, Lane A: Primary Antibody, Lane B: Primary Antibody + Blocking Peptide, Primary Antibody Concentration: 1ug/ml, Peptide Concentration: 5ug/ml, Lysate Quantity: 25ug/lane, Gel Concentration: 0.12% Western Blot: PORCN Antibody [NBP1-59677] - Titration: 0.2-1 ug/ml, Positive Control: HepG2 cell lysate. 100 μL Log in to see 8 to 11 Days
$447.56
Details
Human Rabbit Un-conjugated WB Western Blot: PORCN Antibody [NBP1-79322] - Mouse Thymus Lysate 1ug/ml Gel Concentration 12% Western Blot: PORCN Antibody [NBP1-79322] - Positive control: Lane1 : 50ug PORCN-KO HT1080 (microsomes), Lane2: 50ug HT1080 (microsomes), Lane3: 50ug PORCN transfected HT1080 (microsomes) Primary, Antibody Dilution: 1 : 500 Secondary Antibody: Anti-rabbit-HRP Secondry, Antibody Dilution: 1 : 10,000. 100 μL Log in to see 8 to 11 Days
$447.56
Details
Human Rabbit Un-conjugated WB Western Blot showing Porcn antibody used at a concentration of 1.0 ug/ml against Mouse Thymus Lysate 50 μg Log in to see 6 to 8 Days
$473.93
Details
Human Rabbit Un-conjugated WB PORCN antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 2 to 3 Days
$473.93
Details

PORCN Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human ,


Mouse (Murine)


Rat (Rattus)


Top referenced anti-Porcupine Homolog (Drosophila) Antibodies

  1. Cow (Bovine) Polyclonal PORCN Primary Antibody for IHC, WB - ABIN2783888 : Chen, Li, Li, Fan, Dong, Xu, Wang, Yang, Yan, Wen, Zhang, Niu, Nan, He, Zhou: Suppression of PPN/MG61 attenuates Wnt/beta-catenin signaling pathway and induces apoptosis in human lung cancer. in Oncogene 2008 (PubMed)

More Antibodies against Porcupine Homolog (Drosophila) Interaction Partners

Fruit Fly (Drosophila melanogaster) Porcupine Homolog (Drosophila) (PORCN) interaction partners

  1. Por-mediated lipidation of the S239-equivalent residue is essential for the interaction with, and secretion by, Wls.

  2. stimulates the posttranslational N-glycosylation of wingless in the endoplasmic reticulum

  3. WntD, a recently characterized Drosophila Wnt family member, does not require Porcupine or Wntless/Evi/Sprinter for its secretion or signaling activity

  4. Role of the porcupine gene in the development of the wing imaginal disk of Drosophila melanogaster

Human Porcupine Homolog (Drosophila) (PORCN) interaction partners

  1. Data suggest that PORCN exhibits substrate specificity that includes a Wnt3a (show WNT3A Antibodies) peptide fragment (residues 199-219, with disulfide bonds); recombinant PORCN containing a point mutation (R228C) associated with focal dermal hypoplasia exhibits impaired acylation activity toward Wnt3a (show WNT3A Antibodies) peptide fragment. (PORCN = porcupine O-acyltransferase; Wnt3a (show WNT3A Antibodies) = Wnt (show WNT2 Antibodies) family member 3A)

  2. Inhibition of Wnt (show WNT2 Antibodies) signaling by PORCN inhibition holds promise as differentiation therapy in genetically defined human cancers

  3. three distinct members [porcupine (PORCN), hedgehog (show SHH Antibodies) (Hh) acyltransferase (HHAT (show HHAT Antibodies)) and ghrelin O-acyltransferase (show MBOAT4 Antibodies) (GOAT)] have been shown to acylate specific proteins or peptides.

  4. porcupine-mediated production of Wnts is context dependent and is not required for all Wnts production, suggesting that alternative mechanisms exist for Wnts production.

  5. We describe the first case of non-mosaic males affected with syndromic microphthalmia because of a non-synonymous variant in the PORCN gene.

  6. the Wnt (show WNT2 Antibodies) amino acid residues required for recognition and palmitoylation by PORCN

  7. We describe the ophthalmologic findings in an 18-month-old boy with mosaicism of a novel mutation in PORCN.

  8. a novel variant in the PORCN gene (c.1250T>C:p.F417S) in the focal dermal hypoplasia with spinal anomaly

  9. We report a typical focal dermal hypoplasia (FDH (show ADH5 Antibodies)) patient with a recurrent PORCN mutation, which was previously identified, and a second female, with an almost unilateral FDH (show ADH5 Antibodies) and a novel postzygotic PORCN mutation.

  10. To the best of our knowledge, this is the second case report that reveals a mutation of the PORCN gene in a patient with almost unilateral focal dermal hypoplasia.

Mouse (Murine) Porcupine Homolog (Drosophila) (PORCN) interaction partners

  1. Data suggest that PORCN exhibits substrate specificity that includes a Wnt3a (show WNT3A Antibodies) peptide fragment (residues 199-219, with disulfide bonds); recombinant PORCN containing a point mutation (R228C) associated with focal dermal hypoplasia exhibits impaired acylation activity toward Wnt3a (show WNT3A Antibodies) peptide fragment. (PORCN = porcupine O-acyltransferase; Wnt3a (show WNT3A Antibodies) = Wnt (show WNT2 Antibodies) family member 3A)

  2. Porcupine-dependent Wnt (show WNT2 Antibodies) signaling, unlike previously reported, is dispensable for postnatal gland formation but is required for post-pubertal gland maintenance as well as for stromal cell proliferation.

  3. Overexpression of PORCN enhances the ability of WLS (show WLS Antibodies) to promote WNT1 (show WNT1 Antibodies) trafficking to the cell surface as well as secretion, but decreases the ability of WLS (show WLS Antibodies) to activate WNT1 (show WNT1 Antibodies) signaling in target cell.

  4. Inhibition of porcupine abrogates kidney fibrosis not only by overcoming the redundancy of individual Wnt (show WNT2 Antibodies) isoforms but also by preventing upstream cytokine-induced Wnt (show WNT2 Antibodies) generation.

  5. Conditional PORCN knockout mice exhibit specific changes in AMPAR expression and gating that reduce basal synaptic transmission but leave long-term potentiation intact.

  6. Porcn is required in both extraocular and neuroectodermal tissues to regulate distinct Wnt (show WNT2 Antibodies)-dependent processes during morphogenesis of the posterior and anterior segments of the eye

  7. Residues in predicted transmembrane domain 9 within Porcupine are essential for palmitoleoylation.

  8. Data show bronchopneumonia, rhinitis, and otitis media, suggesting a potential link between Porcn function and the normal development of ciliated cells.

  9. Studies highlight the importance of Wnt3 (show WNT3 Antibodies) and Wnt7b (show WNT7B Antibodies) for embryonic and placental development but suggest that endogenous Porcn-dependent Wnt (show WNT2 Antibodies) secretion does not play an essential role in either implantation or blastocyst lineage specification.

  10. an essential regulatory role of PORCN in shaping Wnt (show WNT2 Antibodies) signaling gradients.

Porcupine Homolog (Drosophila) (PORCN) Antigen Profile

Protein Summary

This gene belongs to the evolutionarily conserved porcupine (Porc) gene family. Genes of the Porc family encode endoplasmic reticulum proteins with multiple transmembrane domains. Porcupine proteins are involved in the processing of Wnt (wingless and int homologue) proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene names and symbols associated with PORCN

  • porcupine (por) antibody
  • porcupine homolog (Drosophila) (PORCN) antibody
  • porcupine homolog (Drosophila) (Porcn) antibody
  • 15175 antibody
  • 2410004O13Rik antibody
  • AW045557 antibody
  • CG6205 antibody
  • DHOF antibody
  • Dmel\\CG6205 antibody
  • dmPorc antibody
  • DXHXS7465e antibody
  • FODH antibody
  • l(1)17Ac antibody
  • MG61 antibody
  • mMg61 antibody
  • Mporc antibody
  • Mporc-a antibody
  • Mporc-b antibody
  • Mporc-c antibody
  • Mporc-d antibody
  • poc antibody
  • PORC antibody
  • porcupine antibody
  • Ppn antibody
  • RGD1564947 antibody

Protein level used designations for PORCN

CG6205-PA , CG6205-PB , CG6205-PC , por-PA , por-PB , por-PC , probable protein-cysteine N-palmitoyltransferase porcupine , protein-cysteine N-palmitoyltransferase porcupine , porcupine-A , porcupine-B , porcupine-C , porcupine-D , porcupine homolog

GENE ID SPECIES
32818 Drosophila melanogaster
64840 Homo sapiens
480903 Canis lupus familiaris
540373 Bos taurus
53627 Mus musculus
317368 Rattus norvegicus
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