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KCNK3 encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. Additionally we are shipping Potassium Channel, Subfamily K, Member 3 Proteins (4) and many more products for this protein.
Showing 10 out of 78 products:
Cow (Bovine) Polyclonal KCNK3 Primary Antibody for WB - ABIN2776142
Rusznák, Pocsai, Kovács, Pór, Pál, Bíró, Szücs: Differential distribution of TASK-1, TASK-2 and TASK-3 immunoreactivities in the rat and human cerebellum. in Cellular and molecular life sciences : CMLS 2004
Show all 3 references for ABIN2776142
The present report supports the contribution of KCNK3 mutations to the genetic etiology of Pulmonary arterial hypertension and strongly suggests that mutations in KCNK3 follow incomplete dominance with worsening of the clinical features in homozygous patients.
In a cohort with idiopathic or hereditary pulmonary arterial hypertension, a possibly associated mutation was found in 11.10% of the idiopathic cases (n = 16) and in 68.18% of the hereditary cases. There were 3 mutations found in KCNK3.
Functional alanine-mutagenesis screens of TASK-1 and TRAAK (show KCNK4 Antibodies) were used to build an in silico model of the TASK-1 cap.
control of TASK-1 trafficking by COPI, kinases, phosphatases and 14-3-3 (show YWHAQ Antibodies) proteins is highly dynamic.
KCNK3 expression and function were reduced in pulmonary artery smooth muscle cells and endothelial cells in human pulmonary arterial hypertension.
TASK-1 and TASK-3 (show KCNK9 Antibodies) may form heterodimers in human atrial cardiomyocytes.
Diacylglycerol mediates regulation of TASK1 and TASK3 potassium channels by GNAQ.
K2P3.1 and K2P9.1 (show KCNK9 Antibodies) undergo rapid dynamin (show DNM1 Antibodies)-dependent endocytosis
Syntaxin-8 (show STX8 Antibodies) regulates the endocytosis of TASK-1.
A glucose-dependent role for beta-cell TASK-1 channels of limiting glucose-stimulated Deltapsip depolarization and insulin (show INS Antibodies) secretion, which modulates glucose homeostasis.
the K(+) channel (show KCNC4 Antibodies) TASK1 controls the thermogenic activity in brown adipocytes through modulation of beta-adrenergic receptor signaling.
KCNK3 channels are not involved in hearing.
An important role for TASK-1 channels in limiting pancreatic alpha-cell excitability and glucagon (show GCG Antibodies) secretion during glucose stimulation.
Oxygen and mitochondrial inhibitors modulate both monomeric and heteromeric TASK-1 and TASK-3 (show KCNK9 Antibodies) channels in mouse carotid body type-1 cells.
This study demonstrated for the first time that oligodendrocytes express functional TASK-1 channels and provide compelling evidence they contribute to oligodendrocyte damage in hypoxia.
TASK-1 deficiency does neither alter key electrophysiological parameters nor increases atrial/ventricular vulnerability after electrical stimulation.
The PCR data revealed the existence of two astrocytic subpopulations markedly differing in their gene expression levels for inwardly rectifying K+ channels (Kir4.1 (show KCNJ10 Antibodies)), K(2P) channels (TREK-1 (show KCNK2 Antibodies) and TWIK-1 (show KCNK1 Antibodies)) and Cl- channels (ClC2 (show CLCN2 Antibodies)).
No difference is found between the pulmonary artery (PA) of wild-type and TASK-1/3-deficient mice; TASK-1 does not form a functional channel in pulmonary artery smooth muscle cells.
TASK-1 is important for the conduction of cardiac excitation and for the ventricular erpolarization under resting conditions of the heart.
This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene.
potassium channel subfamily K member 3
, TWIK-related acid-sensitive K(+) channel 1
, TWIK-related acid-sensitive K+ channel
, acid-sensitive potassium channel protein TASK
, acid-sensitive potassium channel protein TASK-1
, cardiac potassium channel
, potassium inwardly-rectifying channel, subfamily K, member 3
, two P domain potassium channel
, two pore K(+) channel KT3.1
, two pore potassium channel KT3.1
, cardiac two pore background K(+) channel
, TASK-1 potassium channel