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Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Additionally we are shipping KCNN2 Kits (7) and and many more products for this protein.
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Human Polyclonal KCNN2 Primary Antibody for ELISA, IHC - ABIN4328495
Morimoto, Ohya, Hayashi, Onozaki, Imaizumi: Cell-cycle-dependent regulation of Ca2+-activated K+ channel in Jurkat T-lymphocyte. in Journal of pharmacological sciences 2007
Cow (Bovine) Polyclonal KCNN2 Primary Antibody for IHC, WB - ABIN2776144
Feranchak, Doctor, Troetsch, Brookman, Johnson, Fitz: Calcium-dependent regulation of secretion in biliary epithelial cells: the role of apamin-sensitive SK channels. in Gastroenterology 2004
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Cow (Bovine) Polyclonal KCNN2 Primary Antibody for IHC, WB - ABIN2776295
Chakroborty, Kim, Schneider, Jacobson, Molgó, Stutzmann: Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer's disease mice. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
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Study establishes the distribution profile of SK2 channel protein in human brain.The expression of SK2 human isoform b in brain could explain the variability of electrophysiological findings observed with SK2 channels.
These results provide new insights into the regulation of SK2 channel trafficking by the cytoskeletal proteins FLNA (show FLNA Antibodies) and alpha-actinin2, involving distinct recycling pathways
There was a significant association between the KCNN2 variants and clinically significant VTa. These findings suggest an association between KCNN2 and VTa; it also appears that KCNN2 variants may be adjunctive markers for risk stratification in patients susceptible to SCD (show SCD Antibodies).
The ER SK2 channel activation preserves ER Ca(2 (show CA2 Antibodies)+) uptake and retention which determines cell survival in conditions where sustained ER stress contributes to progressive neuronal death.
Differentiated dopaminergic neurons expressed low levels of SK2 channels and high levels of SK1 and SK3 channels.
KCNN2 gene can have an important role in the development of coronary artery aneurysms in Kawasaki disease.
Increase in both Ca(2 (show CA2 Antibodies)+) sensitivity and SK2 protein expression contributes to the IKAS upregulation in failing human ventricles.
Decreased expression of small-conductance Ca2 (show CA2 Antibodies)+-activated K+ channels SK1 (show KCNN1 Antibodies) and SK2 in human chronic atrial fibrillation
RT-PCR analysis showed strong expression of SK2 mRNA in the normal human colon.
Because of the marked differential expression of SK2 channels in the heart, specific ligands for Ca2 (show CA2 Antibodies)+-activated K+ currents may offer a unique therapeutic opportunity to modify atrial cells without interfering with ventricular myocytes
Probing the responsible cellular mechanisms pinpoints a disturbance in the expression and function of small-conductance Ca(2 (show CA2 Antibodies)+)-activated K(+) (SK) channels and reveals an important role for both SK2 (show PAPSS2 Antibodies) and SK3 (show KCNN3 Antibodies) channels in normal regulation of serotinin (5-HT (show DDC Antibodies)) neuronal excitability.
SK2 (show PAPSS2 Antibodies) is nuclear in primary neurons and, unexpectedly, overexpressed SK2 (show PAPSS2 Antibodies) is neurotoxic in a dose-dependent manner.. We also found that SK2 (show PAPSS2 Antibodies) is hyperphosphorylated in the brain samples from a model of HD, the BACHD mice.Our results identify a novel regulator of mutant huntingtin (show HTT Antibodies)-mediated neurotoxicity and provide a new target for developing developing therapies for Huntington disease (show HTT Antibodies)
Thus, MPP2 (show MPP2 Antibodies) is a novel synaptic scaffold that is required for proper synaptic localization and function of SK2 (show PAPSS2 Antibodies)-containing channels.
Atrial SK2 and SK3 are significantly down-regulated from accelerated turnover in diabetic mice, resulting in action potential prolongation and arrhythmias.
enhanced SK2 (show PAPSS2 Antibodies) channel control over NMDAR (show GRIN1 Antibodies) contributes to LTP (show SCP2 Antibodies) impairment via increased PP2A (show PPP2R2B Antibodies) activity following context dependent sensitization to morphine.
This study reveleated that outer hair cells of SK2 (show PAPSS2 Antibodies) knockout mice had few small efferent terminals. Synaptic cisterns were present, but smaller than those of wild-type littermates.
SK2 and SK3 channels are expressed in different populations of motoneurons in rats and mice but not in cats
Mitochondrial small conductance SK2 (show PAPSS2 Antibodies) channels prevent glutamate (show GRIN1 Antibodies)-induced oxytosis and mitochondrial dysfunction.
Virtually all Cav2.1 (show CACNA1A Antibodies) clusters are colocalized in Purkinje cells with two types of calcium-activated potassium channels, SK2 (show PAPSS2 Antibodies) and BK.
A developmental increase and gradient in SK2 (show PAPSS2 Antibodies)-containing channel surface expression is found that underlie the influence on neurotransmission.
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene.
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
, small conductance calcium-activated potassium channel protein 2
, small-conductance calcium-activated potassium channel
, apamin-sensitive small-conductance Ca2+-activated potassium channel
, small conductance potassium channel type 2
, SKCa 2
, small conductance calcium-activated potassium channel subfamily N member 2
, small conductance calcium-activated channel, subfamily N, member 2