anti-Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 2 (KCNN2) Antibodies

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Additionally we are shipping KCNN2 Kits (6) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNN2 3781 Q9H2S1
KCNN2 140492 P58390
KCNN2 54262 P70604
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-KCNN2 Antibodies at antibodies-online.com

Showing 10 out of 39 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB <b>WB Suggested Anti-KCNN2 Antibody Titration: </b>1.25ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>HepG2 cell lysate Host: Rabbit <br /> Target Name: KCNN2 <br /> Sample Tissue: HepG2Lane A:  Primary Antibody Lane B:  Primary Antibody + Blocking Peptide <br />Primary Antibody Concentration: 2.5 µg/mL Peptide Concentration:..0 µg/mL Lysate Quantity:.41 µg/laneGel Concentration: 12 % 100 μL Log in to see 2 to 3 Days
$229.00
Details
Cow Goat Un-conjugated EIA, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Cow Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
$493.17
Details
Human Goat Un-conjugated ELISA, IHC, IHC (p), WB Immunohistochemistry-Paraffin: KCNN2 Antibody [NBP1-46119] - (3.8ug/ml) staining of paraffin embedded Human Thyroid Gland. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Western Blot: KCNN2 Antibody [NBP1-46119] - (0.3ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$408.19
Details
Human Goat Un-conjugated IHC, ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$481.25
Details
Human Goat Un-conjugated IHC (p), ELISA, WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7 to 9 Days
$451.00
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details

KCNN2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
, ,
,
, , , , ,
Mouse (Murine)
,

Rat (Rattus)
,

Top referenced anti-KCNN2 Antibodies

  1. Human Polyclonal KCNN2 Primary Antibody for ELISA, IHC - ABIN4328495 : Morimoto, Ohya, Hayashi, Onozaki, Imaizumi: Cell-cycle-dependent regulation of Ca2+-activated K+ channel in Jurkat T-lymphocyte. in Journal of pharmacological sciences 2007 (PubMed)

  2. Cow (Bovine) Polyclonal KCNN2 Primary Antibody for IHC, WB - ABIN2776144 : Feranchak, Doctor, Troetsch, Brookman, Johnson, Fitz: Calcium-dependent regulation of secretion in biliary epithelial cells: the role of apamin-sensitive SK channels. in Gastroenterology 2004 (PubMed)
    Show all 2 Pubmed References

  3. Cow (Bovine) Polyclonal KCNN2 Primary Antibody for IHC, WB - ABIN2776295 : Chakroborty, Kim, Schneider, Jacobson, Molgó, Stutzmann: Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer's disease mice. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 (PubMed)
    Show all 2 Pubmed References

More Antibodies against KCNN2 Interaction Partners

Human Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 2 (KCNN2) interaction partners

  1. Study establishes the distribution profile of SK2 channel protein in human brain.The expression of SK2 human isoform b in brain could explain the variability of electrophysiological findings observed with SK2 channels.

  2. These results provide new insights into the regulation of SK2 channel trafficking by the cytoskeletal proteins FLNA (show FLNA Antibodies) and alpha-actinin2, involving distinct recycling pathways

  3. There was a significant association between the KCNN2 variants and clinically significant VTa. These findings suggest an association between KCNN2 and VTa; it also appears that KCNN2 variants may be adjunctive markers for risk stratification in patients susceptible to SCD (show SCD Antibodies).

  4. The ER SK2 channel activation preserves ER Ca(2 (show CA2 Antibodies)+) uptake and retention which determines cell survival in conditions where sustained ER stress contributes to progressive neuronal death.

  5. Differentiated dopaminergic neurons expressed low levels of SK2 channels and high levels of SK1 and SK3 channels.

  6. KCNN2 gene can have an important role in the development of coronary artery aneurysms in Kawasaki disease.

  7. Increase in both Ca(2 (show CA2 Antibodies)+) sensitivity and SK2 protein expression contributes to the IKAS upregulation in failing human ventricles.

  8. Decreased expression of small-conductance Ca2 (show CA2 Antibodies)+-activated K+ channels SK1 (show KCNN1 Antibodies) and SK2 in human chronic atrial fibrillation

  9. RT-PCR analysis showed strong expression of SK2 mRNA in the normal human colon.

  10. Because of the marked differential expression of SK2 channels in the heart, specific ligands for Ca2 (show CA2 Antibodies)+-activated K+ currents may offer a unique therapeutic opportunity to modify atrial cells without interfering with ventricular myocytes

Mouse (Murine) Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 2 (KCNN2) interaction partners

  1. SK2 (show PAPSS2 Antibodies) is nuclear in primary neurons and, unexpectedly, overexpressed SK2 (show PAPSS2 Antibodies) is neurotoxic in a dose-dependent manner.. We also found that SK2 (show PAPSS2 Antibodies) is hyperphosphorylated in the brain samples from a model of HD, the BACHD mice.Our results identify a novel regulator of mutant huntingtin (show HTT Antibodies)-mediated neurotoxicity and provide a new target for developing developing therapies for Huntington disease (show HTT Antibodies)

  2. Thus, MPP2 (show MPP2 Antibodies) is a novel synaptic scaffold that is required for proper synaptic localization and function of SK2 (show PAPSS2 Antibodies)-containing channels.

  3. Atrial SK2 and SK3 are significantly down-regulated from accelerated turnover in diabetic mice, resulting in action potential prolongation and arrhythmias.

  4. enhanced SK2 (show PAPSS2 Antibodies) channel control over NMDAR (show GRIN1 Antibodies) contributes to LTP (show SCP2 Antibodies) impairment via increased PP2A (show PPP2R2B Antibodies) activity following context dependent sensitization to morphine.

  5. This study reveleated that outer hair cells of SK2 (show PAPSS2 Antibodies) knockout mice had few small efferent terminals. Synaptic cisterns were present, but smaller than those of wild-type littermates.

  6. SK2 and SK3 channels are expressed in different populations of motoneurons in rats and mice but not in cats

  7. Mitochondrial small conductance SK2 (show PAPSS2 Antibodies) channels prevent glutamate (show GRIN1 Antibodies)-induced oxytosis and mitochondrial dysfunction.

  8. Virtually all Cav2.1 (show CACNA1A Antibodies) clusters are colocalized in Purkinje cells with two types of calcium-activated potassium channels, SK2 (show PAPSS2 Antibodies) and BK.

  9. A developmental increase and gradient in SK2 (show PAPSS2 Antibodies)-containing channel surface expression is found that underlie the influence on neurotransmission.

  10. Sleep spindle occurrence is shaped by SK2 (show PAPSS2 Antibodies)-channel-mediated repetitive reticular thalamic nucleus neuron bursting & contributes to augmented NREMS consolidation & arousal threshold.

KCNN2 Antigen Profile

Protein Summary

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with KCNN2

  • potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 (KCNN2) antibody
  • potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 (LOC100230275) antibody
  • potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 (Kcnn2) antibody
  • fri antibody
  • hSK2 antibody
  • KCa2.2 antibody
  • KCNN2 antibody
  • SK2 antibody
  • SKCA2 antibody
  • SKCa 2 antibody

Protein level used designations for KCNN2

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 , small conductance calcium-activated potassium channel protein 2 , small-conductance calcium-activated potassium channel , apamin-sensitive small-conductance Ca2+-activated potassium channel , small conductance potassium channel type 2 , SKCa 2 , small conductance calcium-activated potassium channel subfamily N member 2 , SK2 , SKCa2 , small conductance calcium-activated channel, subfamily N, member 2

GENE ID SPECIES
695374 Macaca mulatta
100016183 Monodelphis domestica
100172000 Pongo abelii
100230275 Taeniopygia guttata
100589687 Nomascus leucogenys
395579 Gallus gallus
3781 Homo sapiens
474640 Canis lupus familiaris
404177 Bos taurus
140492 Mus musculus
54262 Rattus norvegicus
Selected quality suppliers for anti-KCNN2 (KCNN2) Antibodies
Did you look for something else?