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Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 Proteins (KCNJ11)

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. Additionally we are shipping Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 Antibodies (143) and Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCNJ11 16514 Q61743
Rat KCNJ11 KCNJ11 83535 P70673
KCNJ11 3767 Q14654
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Top Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

KCNJ11 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , ,
, ,

More Proteins for Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11) Interaction Partners

Mouse (Murine) Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11) interaction partners

  1. A Conserved Residue Cluster That Governs Kinetics of ATP-dependent Gating of Kir6.2 Potassium Channels.

  2. ATP-sensitive potassium currents from channels formed by Kir6 and a modified cardiac mitochondrial SUR2 (show ABCC9 Proteins) variant

  3. The Kir6.2-containing K-ATP channel is required for cardioprotection of resveratrol.

  4. Report mechanical dyssynchrony as an early marker of cardiomyopathic disease in ATP-sensitive K channel (show KCNC4 Proteins)-deficient dilated cardiomyopathy.

  5. a role of K(ATP)-channel-dependent neuronal excitability in catecholaminergic neurons in maintaining thermogenic BAT (show BAAT Proteins) sympathetic tone and energy homeostasis.

  6. Data indicate that betaIV-Spectrin-targeted CaMKII (show CAMK2G Proteins) directly phosphorylates the inwardly-rectifying potassium channel (show KCNAB2 Proteins), Kir6.2.

  7. Kir6.2 subunits are critical in resistance to endotoxemia-induced cardiac dysfunction through reducing myocardial damage by inhibition of apoptosis and inflammation.

  8. These findings reveal unrecognized slide helix elements that are required for functional channel expression and control of Kir6.2 gating by intracellular ATP.

  9. We found that perfused hearts from Kir6.2(-/-) mice exhibited a normal baseline response to ischemia-reperfusion injury, were not protected by ischemic preconditioning

  10. Data from Kir6.2 knockout mice suggest that KATP channel-independent mechanism mediated by vagus nerve plays critical role in insulin (show INS Proteins) secretion by pancreatic beta cells in response to eating of dietary carbohydrates.

Human Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11) interaction partners

  1. This studypredict response ketogenic dietary therapies. showed that Common variants in KCNJ11 and BAD do not response to ketogenic diety therapy.

  2. KCNJ11 genetic variants may have a role in the development of diabetes mellitus [review]

  3. Mutations in KCNJ11 are associated with neonatal diabetes mellitus.

  4. The hORs were coupled to the Kir6.2 potassium channel (show KCNAB2 Proteins) for simple odorant detection.

  5. We performed a retrospective cohort study using data on 58 individuals with neonatal diabetes due to KCNJ11 mutations

  6. Polymorphism rs5219 of KCNJ11 gene is associated with type 2 diabetes.

  7. KCNJ11 SNP was associated with diabetic retinopathy in Chinese Han patients with T2DM.

  8. These calculations identified causal genetic variation within the ABCC8 (show ABCC8 Proteins)/KCNJ11 region for type 2 diabetes mellitus.

  9. A190A-TT or E23K-GG of the KCNJ11 in carriers had higher systolic blood pressure (SBP (show SHBG Proteins)) than CC or AA carriers in the non-diabetic control and T2DM groups (both p < 0.05).

  10. The KCNJ11 gene encodes for the Kir6.2 subunit of the ATP-sensitive potassium channel (show KCNAB2 Proteins) in the pancreatic beta cell; thus, mutations in this gene cause impaired insulin (show INS Proteins) secretion.

Rabbit Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11) interaction partners

  1. Although the expression level of Kir6.2 channel subtype does not differ between aortic smooth muscle cells of control and hypertrophied models, those of Kir6.1 (show KCNJ8 Proteins) and SUR2B (show ABCC9 Proteins) subtypes are reduced in left ventricular hypertrophy models.

Pig (Porcine) Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11) interaction partners

  1. islets express mRNA transcripts for sulfonylurea receptor 1 (Sur1 (show ABCC8 Proteins)), inward rectifying potassium channel (show KCNAB2 Proteins) (Kir6.2, associated with Sur1 (show ABCC8 Proteins)), glucagon-like peptide 1 receptor (GLP1R (show GLP1R Proteins)), and adrenergic receptor alpha 2A (show ADRA2A Proteins) (ADRalpha2A)

  2. The predominant K(ATP) channel expressed in pig urethral smooth muscle possesses a unique, heteromeric pore structure with a pore-forming subunit composition of (Kir6.1 (show KCNJ8 Proteins))(3)-(Kir6.2).

Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11) Protein Profile

Protein Summary

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Gene names and symbols associated with KCNJ11

  • potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11)
  • potassium inwardly-rectifying channel, subfamily J, member 11 (kcnj11)
  • potassium inwardly rectifying channel, subfamily J, member 11 (Kcnj11)
  • BIR protein
  • HHF2 protein
  • IKATP protein
  • KIR6.2 protein
  • mBIR protein
  • PHHI protein
  • TNDM3 protein

Protein level used designations for KCNJ11

potassium inwardly-rectifying channel, subfamily J, member 11 , potassium inwardly-rectifying channel J11 , ATP-sensitive inward rectifier potassium channel 11 , ATP-sensitive inward rectifier potassium channel 11-like , inward rectifier K(+) channel Kir6.2 , BIR , potassium channel, inwardly rectifying subfamily J member 11 , potassium inwardly-rectifying channel subfamily J member 11 , IKATP , inward rectifier potassium channel Kir6.2 , beta-cell inward rectifier subunit , inwardly rectifying potassium channel KIR6.2 , potassium channel inwardly rectifing subfamily J member 11 , potassium inwardly rectifying channel, subfamily J, member 11 , ATP-sensitive inward rectifier potassium channel Kir6.2 , inwardly rectifying potassium channel Kir6.2

GENE ID SPECIES
428846 Gallus gallus
466450 Pan troglodytes
664687 Danio rerio
100401039 Callithrix jacchus
100456411 Pongo abelii
16514 Mus musculus
83535 Rattus norvegicus
100135564 Cavia porcellus
3767 Homo sapiens
485401 Canis lupus familiaris
100008648 Oryctolagus cuniculus
100158240 Sus scrofa
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