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Potassium Inwardly-Rectifying Channel, Subfamily J, Member 2 Proteins (KCNJ2)

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. Additionally we are shipping KCNJ2 Antibodies (87) and KCNJ2 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCNJ2 3759 P63252
Rat KCNJ2 KCNJ2 29712 Q64273
KCNJ2 16518 P35561
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Top KCNJ2 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

KCNJ2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Potassium Inwardly-Rectifying Channel, Subfamily J, Member 2 (KCNJ2) Interaction Partners

Human Potassium Inwardly-Rectifying Channel, Subfamily J, Member 2 (KCNJ2) interaction partners

  1. Variability has been found in a three-generation family with Pierre Robin sequence, acampomelic campomelic dysplasia, and intellectual disability due to a novel approximately 1 Mb deletion upstream of SOX9 (show SOX9 Proteins), and including KCNJ2 and KCNJ16 (show KCNJ16 Proteins).

  2. Patients with Dilated Cardiomyopathy and Sustained Monomorphic Ventricular Tachycardia Show Up-Regulation of KCNN3 and KCNJ2 Genes and CACNG8-Linked Left Ventricular Dysfunction

  3. Results indicate that silencing BKCa (KCa1.1 (show KCNMA1 Proteins)) inhibits cell mobility, while silencing IKir (Kir2.1) increases cell mobility in human cardiac c-kit+ progenitor cells.

  4. No genetic variants were identified in the KCNJ2 gene in this cohort of Chinese thyrotoxic periodic paralysis patients.

  5. Kir2.1 channels exhibit a binding site determined by Cys311 that is responsible for drug-induced increases in inward rectifier Kir2.1 currents.

  6. Kir2.1 channel function is essential during osteoblastogenesis.

  7. Upregulation of the inwardly rectifying potassium channel Kir2.1 (KCNJ2) modulates multidrug resistance of small-cell lung cancer under the regulation of miR-7 (show LILRB1 Proteins) and the Ras/MAPK (show MAPK1 Proteins) pathway.

  8. propose that Kir2.1 currents control the interspike interval, and predict that blocking Kir2.1 channels increases the action potential frequency, which should augment the rate of insulin (show INS Proteins) secretion in pancreatic beta cells

  9. Results show that K346T mutation causes gain of function of the Kir2.1 channels by altering their trafficking and stabilization suggesting that the variant has a combined effect on cardiac rhythm and neuropsychiatric phenotype.

  10. This study demonistrated that KCNJ2 mutations cause a variable phenotype, with dysmorphic features seen in all patients studied, a high penetrance of periodic paralysis in males and ventricular arrhythmia with a risk of sudden cardiac death.

Mouse (Murine) Potassium Inwardly-Rectifying Channel, Subfamily J, Member 2 (KCNJ2) interaction partners

  1. Consistent with a role of the K(+) current in amplifying the sensory response, entry of protons through the Zn(2+)-sensitive conductance produces a transient block of the KIR2.1 current.

  2. Mouse neutrophils express functional Kir2.1 channels from bone marrow and liver.

  3. A184R mutation in the inner end of the bundle crossing region of Kir2.1 not only abolishes the inward rectifying features of spermine block but also tends to close the channel pore.

  4. the present work demonstrates that a functional Kir2.1-like channel is expressed in lactating mouse mammary secretory cells.

  5. Kir2.1 mRNA levels were downregulated by LPS (show TLR4 Proteins), and to a lesser extent by IL-4 (show IL4 Proteins)/IL-13 (show IL13 Proteins).

  6. Report pentamidine analogue which specifically blocks cardiac KIR2.1 channel, lengthening action potential duration.

  7. The total Kcnj2 (gene for the Kir2.1 potassium channel (show KCNAB2 Proteins)) mRNA was reduced in Huntington disease (show HTT Proteins) skeletal muscle.

  8. miR (show MLXIP Proteins)-26 controls the expression of KCNJ2 and may have a role in atrial fibrillation

  9. Stronger expressions of SCN5a (show SCN5A Proteins), SCN1b (show SCN1B Proteins) and Kir2.1 were observed in ventricular-like and atrial-like cells compared to that of pacemaker-like cardiomyocytes.

  10. The data of this study suggested that Kir2.1 is required for I(K1) in type II utricle hair cells.

Cow (Bovine) Potassium Inwardly-Rectifying Channel, Subfamily J, Member 2 (KCNJ2) interaction partners

  1. Kir2.1 may mediate native Kir currents responsible for setting resting membrane potential in bovine parotid cells and might be, at least in part, involved in spontaneous secretion in ruminant parotid glands.

Rabbit Potassium Inwardly-Rectifying Channel, Subfamily J, Member 2 (KCNJ2) interaction partners

  1. There were substantial transmural gradients in Cav1.2, KChIP2, ERG, KvLQT1, Kir2.1, NCX1, SERCA2a and RyR2 at the mRNA and, in some cases, protein level-in every case the mRNA or protein was more abundant in the epicardium than the endocardium.

KCNJ2 Protein Profile

Protein Summary

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features.

Gene names and symbols associated with KCNJ2

  • inward rectifier potassium channel (IRK1)
  • potassium inwardly-rectifying channel, subfamily J, member 2 (KCNJ2)
  • potassium inwardly-rectifying channel, subfamily J, member 2 (Kcnj2)
  • ATFB9 protein
  • HHBIRK1 protein
  • HHIRK1 protein
  • IRK-1 protein
  • IRK1 protein
  • Kcnf1 protein
  • KCNJ2 protein
  • Kir2.1 protein
  • LQT7 protein
  • SQT3 protein

Protein level used designations for KCNJ2

IRK-1 , inward rectifier K(+) channel Kir2.1 , inward rectifier potassium channel 2 , potassium channel, inwardly rectifying subfamily J member 2 , cardiac inward rectifier potassium channel , hIRK1 , inward rectifier K+ channel KIR2.1 , RBL-IRK1 , BIK , inward rectifier potassium channel cIRK1 , cardiac inward rectifier KIR2.1 , inwardly rectifying potassium channel Kir2.1 , inward rectifier potassium channel Kir2.1 , inwardly-rectifying potassium channel Kir2.1

GENE ID SPECIES
397293 Sus scrofa
3759 Homo sapiens
29712 Rattus norvegicus
16518 Mus musculus
281883 Bos taurus
396328 Gallus gallus
403717 Canis lupus familiaris
100135566 Cavia porcellus
100008987 Oryctolagus cuniculus
574189 Macaca mulatta
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