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Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 Proteins (KCNQ2)

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. Additionally we are shipping Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 Antibodies (84) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KCNQ2 3785 O43526
Rat KCNQ2 KCNQ2 170848 O88943
KCNQ2 16536 Q9Z351
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Top Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

KCNQ2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
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More Proteins for Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) Interaction Partners

Horse (Equine) Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) interaction partners

  1. The KCNQ2 and KCNQ3 genes are located on the terminal region of chromosomes 22 and 9, respectively. The KCNQ2 gene tree exhibited close clustering between horses and humans, relative to horses and mice.

Human Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) interaction partners

  1. a structural mechanism for the gating of the Kv7.3 PM and for the site of action of RTG as a Kv7.2/Kv7.3 K(+) current activator.

  2. There is a variable clinical expression in infantile epilepsy patients with mosaicism for KCNQ2 mutations.

  3. Our data indicate that the TW site is dispensable for function, contributes to the stabilization of the CaM (show CALM1 Proteins)-Kv7.2 complex and becomes essential when docking to either helix A or when helix B is perturbed.

  4. all the patients carrying the p.A294V mutation of KCNQ2 presented the clinical and EEG characteristics of early onset epileptic encephalopathy

  5. Kcnq2 protein and mRNA expression and DNA methylation (show HELLS Proteins) status did not differ significantly between bipolar disorder patients and controls.

  6. A novel and rare mutation was identified in KCNQ2 and was likely responsible for the benign seizures.

  7. Phosphorylation of KCNQ2 and KCNQ3 anchor domains by protein kinase CK2 augments binding to AnkG.

  8. The results of thus study suggested that the type of KCNQ2 mutation might influence Antiepileptic drug response epilepsy as well as developmental outcome.

  9. Epileptic encephalopathy related to mutations in the KCNQ2 genes.

  10. Collectively, this work reveals that residue C106 in S1 can be very close to several N-terminal S4 residues for stabilizing different KCNQ2 resting conformations.

Mouse (Murine) Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) interaction partners

  1. Mechanosensitivity of Skin Down-hair mechanoeceptors is increased in Kcnq3-/- and in Kcnq2+/-/Kcnq3-/- Mutant Mice.

  2. Resilience to tinnitus is developed in mice that show a re-emergence of KCNQ2/3 channel activity and a reduction in HCN channel activity.

  3. Reduced M-current in the superior cervical ganglion neurons of Kcnq2 truncation mutation heterozygotic mice.

  4. Data show that a reduction in Kv7.2/3 channel activity is essential for tinnitus induction and for the tinnitus-specific hyperactivity.

  5. Retigabine is more effective on KCNQ3 than KCNQ2, whereas ZnPy is more effective on KCNQ2 with no detectable effect on KCNQ3.

  6. Results show that in the same protein complex in which PKA augments L currents, AKAP79 (show AKAP5 Proteins)/150 directs calcineurin (show PPP3CA Proteins) to activate NFAT (show NFATC1 Proteins) and initiate a longer-term feedback loop that upregulates M-channel expression, countering increased neuronal excitability.

  7. Data show that in early pregnant mouse myometrium, the relative abundance of mRNA expression was KCNQ3 > KCNQ4 (show KCNQ4 Proteins) > KCNQ5 (show KCNQ5 Proteins) > KCNQ1 (show KCNQ1 Proteins) > KCNQ2.

  8. These findings provide novel evidence that KCNQ2/3 channels could be an important regulator in neuronal apoptosis.

  9. These findings demonstrate that spectrin cytoskeleton finely regulates ion channel distribution and implicates KCNQ2/3 subunits in axonal excitability and in myokymia etiology.

  10. Suppression of neuronal KCNQ2 current in mice is associated with spontaneous seizures, behavioral hyperactivity and morphological changes in hippocampus.

Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2) Protein Profile

Protein Summary

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.

Gene names and symbols associated with KCNQ2

  • potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2)
  • potassium voltage-gated channel, KQT-like subfamily, member 2 (Kcnq2)
  • potassium voltage-gated channel, KQT-like subfamily, member 2 (kcnq2)
  • potassium voltage-gated channel, subfamily Q, member 2 (Kcnq2)
  • BFNC protein
  • BFNS1 protein
  • EBN protein
  • EBN1 protein
  • EIEE7 protein
  • ENB1 protein
  • HNSPC protein
  • KCNA11 protein
  • KQT2 protein
  • KV7.2 protein
  • KVEBN1 protein
  • Nmf134 protein

Protein level used designations for KCNQ2

KQT-like 2 , neuroblastoma-specific potassium channel protein , neuroblastoma-specific potassium channel subunit alpha KvLQT2 , potassium voltage-gated channel subfamily KQT member 2 , voltage-gated potassium channel subunit Kv7.2 , potassium channel subunit alpha KvLQT2 , potassium voltage-gated channel, subfamily Q, member 2

GENE ID SPECIES
100146986 Equus caballus
3785 Homo sapiens
170848 Rattus norvegicus
100537363 Danio rerio
428151 Gallus gallus
505963 Bos taurus
16536 Mus musculus
612515 Canis lupus familiaris
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