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The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Additionally we are shipping Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 Antibodies (139) and many more products for this protein.
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Kv3.1 channels stimulate adult neural precursor cell proliferation and neuronal differentiation.
The resting (closed) Kv3.1 channel conformation forms the high-affinity state for gambierol.
high-affinity multimeric binding between the Kv3.1 T1 domain and KIF5B (show KIF5B Proteins) requires three basic residues in the KIF5B (show KIF5B Proteins) tail. Kv3.1 T1 competes with the motor domain and microtubules, but not with kinesin light chain 1 (KLC1 (show KLC1 Proteins)), for binding to the KIF5B (show KIF5B Proteins) tail.
Although all Kv3 (show KCNA3 Proteins) transcripts were significantly expressed at embryonic age in whole brain extracts, only Kv3.1, Kv3.2 and Kv3.4 su (show KCNC2 Proteins)bunit prot (show KCNC4 Proteins)eins were present, suggesting a novel role for Kv3 channels at this developmental stage.
Block of Kv3.1 channels hinders spike repolarization and severely depresses evoked fast firing in deep cerebellar nuclear neurons.
Mice lacking both Kcnc1 and Kcnc2 (show KCNC2 Proteins) genes fail to express the Kv3.1 and Kv3.2 (show KCNC2 Proteins) channels in in the suprachiasmatic nucleus.
These results provide evidence that acoustically driven auditory activity can selectively regulate high-threshold potassium currents in the MNTB of normal hearing mice, likely due to an increased membrane expression of Kv3.1b channels.
As Kcnc1, but not Kcnc3, alleles are lost, mutant mice exhibit increasing gait ataxia accompanied by spike broadening and deceleration in deep cerebellar nuclei. neurons.
interaction with CALP/KCHIP4 (show KCNIP4 Proteins)
NCS-1 (show NCS1 Proteins) is an accessory subunit of Kv4-encoded I(to,f) channels that functions to regulate I(to,f) density in the mammalian myocardium.
A nonsense variant in KCNC1 gene was identified in three family members with intellectual disability without seizures.
reviews the phenotype/genotype of progressive myoclonus epilepsy and ataxia due to potassium channel (show KCNAB2 Proteins) mutation (MEAK)associated with KCNC1 mutations [review]
KCNC1 produces a resurgent current during repolarization, ensuring enough repolarizing power to terminate each action potential. The current results from a combination of steep voltage-dependent gating kinetics and ultra-fast voltage-sensor relaxation.
A recurrent KCNC1 de novo mutation, c.959G>A (p.Arg320His), is a new major cause for progressive myoclonus epilepsy. It has a dominant-negative loss-of-function effect.
Describes two rat isoforms of Kv3.1, alpha is the longer one and beta is the shorter one
KChIP4a (show KCNIP4 Proteins) suppresses A-type Kv4 current via ER retention and enhancement of Kv4 closed-state inactivation.
Although all KV3 (show KCNA3 Proteins) subunit transcripts are significantly expressed at embryonic age in whole mouse brain extracts, only KV3.1, KV3.2 (show KCNC2 Proteins) and KV3.4 (show KCNC4 Proteins) subunit transgenic proteins are present.
demonstrated that glycosylation was necessary for both DPP10 trafficking to the cell surface and functional interaction with Kv4 channels
Kv3.1 channels are transported into axons by binding to kinesin I.
In the absence of potassium ion, significant N-methyl-D-glucamine (NMDG)-positive currents could be recorded from human embryonic kidney cells expressing Kv3.1 or Kv3.2b channels and Kv1.5 (show KCNA5 Proteins) Arg487Tyr/Val, but not wild-type channels.
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Multiple transcript variants encoding different isoforms have been inferred for this gene based on orthologous loci.
potassium voltage-gated channel, Shaw-related subfamily, member 1
, potassium channel Kv3.1
, potassium voltage-gated channel subfamily C member 1
, voltage-gated potassium channel subunit Kv3.1
, voltage-gated potassium channel subunit Kv4
, potassium channel gene 1
, voltage-gated potassium channel protein KV3.1
, Shaw-related voltage-gated potassium channel protein 1
, potassium channel
, voltage-gated potassium channel KCNC1
, voltage-gated potassium channel Kv3.1a