anti-Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) Antibodies

KCNH2 encodes a voltage-activated potassium channel belonging to the eag family. Additionally we are shipping Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNH2 3757 Q12809
KCNH2 16511  
KCNH2 117018 O08962
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Top anti-Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Antibodies at antibodies-online.com

Showing 10 out of 94 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-KCNH2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>OVCAR-3 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Anti- KCNH2 Picoband antibody, Western blotting All lanes: Anti KCNH2  at 0.5ug/ml Lane 1: Rat Brain Tissue Lysate at 50ug Lane 2: HELA Whole Cell Lysate at 40ug Lane 3: COLO320 Whole Cell Lysate at 40ug Lane 4: MM231 Whole Cell Lysate at 40ug Predicted bind size: 127KD Observed bind size: 127KD Anti- KCNH2 Picoband antibody, Western blotting All lanes: Anti KCNH2  at 0.5ug/ml WB: Recombinant Human KCNH2 Protein 0.5ng Predicted bind size: 42KD Observed bind size: 42KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of KCNH2 Antibody (Center) in CEM cell line lysates (35ug/lane).KCNH2 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, WB Western blot analysis of KCNH2 Antibody (Center) (ABIN652759) in CEM cell line lysates (35 µg/lane).KCNH2 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Kcnh2 Antibody Titration: 1.0 ug/ml Positive Control: Mouse Kidney 100 μL Log in to see 2 to 3 Days
$289.00
Details
Dog Rabbit Un-conjugated IF (p), IHC (p), WB   100 μL Log in to see 3 to 7 Days
$295.90
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using KCNH2 antibody. 100 μL Log in to see 16 Days
$323.13
Details
Cow Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Dog Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Bat Rabbit Un-conjugated IHC (p) Anti-KCNH2 / Kv11.1 antibody  ABIN1048984 IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 7 to 9 Days
$451.00
Details

KCNH2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Antibodies

  1. Dog (Canine) Polyclonal KCNH2 Primary Antibody for IF (p), IHC (p) - ABIN734843 : Zhao, Xu, Yun, Zhao, Li, Gong, Yuan, Yan, Zhang, Ding, Wang, Zhang, Dong, Xiu, Yang, Liu, Xue, Li: Chronic obstructive sleep apnea causes atrial remodeling in canines: mechanisms and implications. in Basic research in cardiology 2014 (PubMed)

More Antibodies against Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Interaction Partners

Zebrafish Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. RNF207 is an important regulator of action potential duration, likely via effects on HERG trafficking and localization in a heat shock protein-dependent manner.

  2. The data support the conclusion that zerg-2 and zerg-3 are apparent orthologues of different human genes encoding potassium ion channels, but that their functions have switched compared to the respective human proteins.

  3. role for ERG in leukocytes, where inhibition or translational knockdown of ERG resulted in significant attenuation of the inflammatory response to an infectious stimulus

  4. Mutations in kcnh2 recapitulate the human long QT syndrome (LQTS) phenotype as manifested by prolongation of action potentials and prolonged QT interval in the first animal genetic model of human LQTS type 2.

  5. The reg mutation in the voltage sensor of the ether-a-go-go-related gene gene K+ channel (show KCNC4 Antibodies) causes premature zERG channel activation & defective inactivation, resulting in shortened action-potential duration & accelerated cardiac repolarization

Human Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. ER-located J-protein chaperones were identified as key regulators for the iogenesis and physiological function of ERG (show ERG Antibodies) K+ channels. They regulate two distinct aspects of K+ channel (show KCNC4 Antibodies) biogenesis, the stabilization and assembly of channel subunits.

  2. atypical sequence of the pore helix of hERG may play a key role in determining how anionic lipids influence its gating

  3. Besides a prolonged cardiac repolarization phase, LQT2 patients display increased GLP-1 (show GCG Antibodies), GIP (show GIP Antibodies), and insulin (show INS Antibodies) secretion and defective glucagon (show GCG Antibodies) secretion, causing decreased plasma glucose and thus increased risk of hypoglycemia.

  4. BIMU8 is a potent blocker of hERG, NaV1.5 (show SCN5A Antibodies) and CaV1.2 (show CACNA1C Antibodies) cardiac ion channels, inducing cardiac arrhythmias.

  5. The K897T polymorphism in the hERG1 gene has been reported as an important modifier of the IKr current, probably leading to QT interval prolongation-as it is observed in the LQT2 syndrome.

  6. Stabilization of the Activated hERG Channel Voltage Sensor by Depolarization Involves the S4-S5 Linker

  7. Study determined the structure of hERG using cryo-electron microscopy; the voltage sensors are depolarized, and the inner helical gate is open; an unusual geometry of the "central cavity" within hERG's ion conduction pathway; hERG contains a subtle difference in the structure of its selectivity filter compared to all other K+ channels so far analyzed.

  8. S1 region mutations would reduce both the action potential repolarizing current passed by Kv11.1 channels in cardiac myocytes, as well as the current passed in response to premature depolarizations that normally helps protect against the formation of ectopic beats.

  9. hERG mediated by proteases such as calpain may contribute to ischemia-associated QT prolongation and sudden cardiac death

  10. the two tyrosine residues in the Kv11.1 S4S5 linker play critical but distinct roles in the slow deactivation phenotype, which is a hallmark of Kv11.1 channels.

Rabbit Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. RNF207 is an important regulator of action potential duration, likely via effects on HERG trafficking and localization in a heat shock protein-dependent manner.

  2. In transgenic long QT syndrome rabbits, Kv11.1 channel activation shortens the cardiac activation potential duration.

Mouse (Murine) Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) interaction partners

  1. Using a combination of mouse genetics, biochemistry, molecular and cell biology, we demonstrate that Nkx2-5 (show NKX2-5 Antibodies) regulates the gene encoding Kcnh2 channel and others, shedding light on potential mechanisms generating electrical abnormalities observed in patients bearing NKX2-5 (show NKX2-5 Antibodies) dysfunction and opening opportunities to the study of novel therapeutic targets for anti-arrhythmogenic therapies

  2. Report altered protein trafficking/function of mouse ERG K(+) channel clones.

  3. Enhancement of HERG protein expression through Hsp90 (show HSP90 Antibodies) inhibition of CHIP binding might be a novel therapeutic strategy for long QT syndrome 2 caused by trafficking abnormalities of HERG proteins.

  4. The findings of this study suggested that MERG1a may not modulate Murf1 (show TRIM63 Antibodies) expression through the AKT (show AKT1 Antibodies)/FOXO (show FOXO3 Antibodies) pathway.

  5. Data indicate presence of KCNH2 in left/right atria & indicate functional interaction between KCNH2 & KCNA5 (show KCNA5 Antibodies). Kinetic analyses confirm KCNH2 as "rapid" and KCNA5 (show KCNA5 Antibodies) as "ultra rapid" potassium channels.

  6. Knockdown of mERG1 transcripts with small interfering RNA (siRNA) dramatically reduced I (Kr) amplitude, confirming the molecular link of mERG1 and I (Kr) in HL-1 (show ASGR1 Antibodies) cells.

  7. The LQT2 missense mutations G601S and N470D hERG exhibited altered protein trafficking in mouse cardiomyocytes.

  8. ERG1 B is necessary for I(Kr) expression in the surface membrane of adult myocytes. Knockout of ERG1 B predisposes mice to episodic sinus bradycardia.

  9. erg1 gene expression pattern in the developing embryo.

  10. MERG1A is developmentally regulated, and it might play a role in early mouse embryogenic development.

Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) Antigen Profile

Protein Summary

This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified.

Gene names and symbols associated with KCNH2

  • potassium voltage-gated channel, subfamily H (eag-related), member 2 (kcnh2) antibody
  • potassium voltage-gated channel, subfamily H (eag-related), member 2 (KCNH2) antibody
  • potassium voltage-gated channel subfamily H member 2-like (LOC100858122) antibody
  • potassium voltage-gated channel subfamily H member 2-like (LOC100523293) antibody
  • potassium voltage-gated channel, subfamily H (eag-related), member 2 (Kcnh2) antibody
  • potassium voltage-gated channel, subfamily H (eag-related), member 6 (KCNH6) antibody
  • AI326795 antibody
  • cerg antibody
  • derg antibody
  • ERG antibody
  • erg1 antibody
  • gp-erg antibody
  • HERG antibody
  • HERG1 antibody
  • KCNH2 antibody
  • Kv11.1 antibody
  • LQT antibody
  • Lqt2 antibody
  • M-erg antibody
  • Merg1 antibody
  • merg1a antibody
  • merg1b antibody
  • SQT1 antibody

Protein level used designations for KCNH2

bre , breakdance , erg K+ channel , reg , reggae , silent ventricle , unm s213 , zerg , potassium voltage-gated channel, subfamily H (eag-related), member 2 , potassium voltage-gated channel subfamily H member 2-like , ERG-1 , H-ERG , eag homolog , eag-related protein 1 , ether-a-go-go-related gene potassium channel 1 , ether-a-go-go-related potassium channel protein , ether-a-go-go-related protein 1 , hERG-1 , potassium voltage-gated channel subfamily H member 2 , voltage-gated potassium channel subunit Kv11.1 , c-ERG , eag related protein 1 , ether-a-go-go related gene potassium channel 1 , potassium channel protein ERG , ERG1 , RERG , ra-erg , ventricular ERG K+ channel subunit , voltage-gated potassium channel 11.1 , voltage-gated potassium channel, subfamily H, member 2 , MERG , ether a go-go related , r-ERG , Ether-a-go-go-related gene potassium channel 1 , Potassium voltage-gated channel subfamily H member 2 , HERG protein

GENE ID SPECIES
405763 Danio rerio
463894 Pan troglodytes
100064000 Equus caballus
100413935 Callithrix jacchus
100447585 Pongo abelii
100858122 Gallus gallus
100523293 Sus scrofa
3757 Homo sapiens
403761 Canis lupus familiaris
100009242 Oryctolagus cuniculus
16511 Mus musculus
117018 Rattus norvegicus
397334 Sus scrofa
100135563 Cavia porcellus
414871 Gallus gallus
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