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endogenous ligand of the opioid-like orphan receptor; reduces neuronal excitability and induces an increase in inward rectifying K+ conductance in thalamic neurons. Additionally we are shipping Prepronociceptin Antibodies (98) and and many more products for this protein.
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The presence of the PNOC rs732636 A allele was associated with the worse Neonatal abstinence syndrome outcomes in infants.
Study presents evidence suggesting that the PNOC and OPRL1 (show OPRL1 ELISA Kits) are dysregulated in suicide completers, thereby potentially contributing to impaired emotional and behavioral control and, ultimately, to the suicidal crisis
findings suggest that SNPs in opioid receptors and the PNOC genes are associated with NAS (show SCN9A ELISA Kits) severity.
Data suggest that nociceptin and nociceptin receptor (show OPRL1 ELISA Kits) evolved as one of 4 opioid receptor systems in vertebrates; this system exhibits both analgesic and hyperalgesic effects. [REVIEW]
Data suggest that nociceptin plays a crucial role in progress of meiosis during spermatogenesis. [REVIEW]
Opioid neuropeptide systems are important mediators of ovarian steroid signaling that regulate reproduction in female; data suggest that nociceptin and nociceptin receptor (show OPRL1 ELISA Kits) system in arcuate nucleus of hypothalamus is such a system. [REVIEW]
Data suggest that both nociceptin and nocistatin inhibit myometrial contractions and may play roles in perception of pain during delivery. [REVIEW]
Data suggest that the nociceptin/nociceptin receptor (show OPRL1 ELISA Kits) system is involved in modulation of the immune response and in pathogenesis of autoimmune diseases. [REVIEW]
Data suggest that the nociceptin/nociceptin receptor (show OPRL1 ELISA Kits) system is involved in modulation of psychological and inflammatory stress responses and in pathogenesis of anxiety. [REVIEW]
Data suggest that interaction between the nociceptin/nociceptin receptor (show OPRL1 ELISA Kits) system and the orexin/orexin (show OX ELISA Kits) receptor system in neurons of the hypothalamus positively and negatively modulate complex and integrated responses to stress. [REVIEW]
the present results suggest that the endogenous OFQ/N/NOP (show CRYGB ELISA Kits) receptor system may modulate the development of cocaine-induced locomotor sensitization.
Data suggest that nociceptin/nociceptin receptor (show OPRL1 ELISA Kits) signaling plays a role in the disease pathogenesis of inflammatory bowel diseases.
these findings may identify nociceptin as a novel paracrine mediator of the FSH (show BRD2 ELISA Kits) effects in the regulation of spermatogenesis.
MPTP (show PTPN2 ELISA Kits) increased by about 5-fold the number of neurons expressing ppN (show PORCN ELISA Kits)/OFQ mRNA in the pars (show EPRS ELISA Kits) reticulata of the substantia nigra by 24 h after treatment and the elevation remained significant for at least 7 days.
Endogenous nociceptin/orphanin FQ contributes to reserpine-induced parkinsonism.
N/OFQ and NOP (show CRYGB ELISA Kits) receptors have an important role in hippocampus-dependent spatial learning and memory, probably by modulation of glutamatergic functions
reduction in endogenous N/OFQ, or the lack of its receptor, causes an increase in capsaicin-induced bronchoconstriction, implying a role for the N/OFQ-NOP (show CRYGB ELISA Kits) receptor system in the modulation of capsaicin effects
This neuropeptide was tagged with a green fluorescent protein to visualize secretory vesicle dynamics in mouse neuroblastoma (show ARHGEF16 ELISA Kits) cells and cultures of primary hippocampus neurons.
The N/OFQ receptor (show OPRL1 ELISA Kits) was seen at high levels in a subset of neurons showing large cell size and indented nucleus in the anterior hypothalamic area.
The nocifensive responses were potentiated in NOP (show CRYGB ELISA Kits)(-/-) mice
The aim of the study was to determine by immunochemistry the expression of leptin (show LEP ELISA Kits), orexin A and orphanin FQ in the major salivary glands (parotid, submandibular and sublingual) of rat, sheep and cow.
endogenous ligand of the opioid-like orphan receptor; reduces neuronal excitability and induces an increase in inward rectifying K+ conductance in thalamic neurons
, Prepronociceptin (neuropeptide nociceptin) (N23K)
, neuropeptide nociceptin 1
, orphanin FQ