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Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 3 Proteins (PLOD3)

The protein encoded by PLOD3 is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. Additionally we are shipping PLOD3 Antibodies (38) and PLOD3 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PLOD3 26433 Q9R0E1
PLOD3 288583 Q5U367
PLOD3 8985 O60568
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Top PLOD3 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,082.83
Details

PLOD3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human ,
,

More Proteins for Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 3 (PLOD3) Interaction Partners

Zebrafish Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 3 (PLOD3) interaction partners

  1. LH3 directs target-selective motor axon regeneration.

  2. Together these data suggest that Lh3-Collagen18A1 dependent ECM (show MMRN1 Proteins) modifications regulate the transition of trunk neural crest cells from a non-segmental sheet like migration mode to a segmental stream migration mode

  3. diwanka (lh3) acts through myotomal type XVIII collagen, a ligand for neural-receptor protein tyrosine phosphatases that guide motor axons

Mouse (Murine) Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 3 (PLOD3) interaction partners

  1. Data indicate that lysyl hydroxylase 3 is essential for the glucosyltion of mannan-binding lectin MBL (show MBL2 Proteins)-A.

  2. LH3 is an important regulator of adiponectin (show ADIPOQ Proteins) biosynthesis, secretion and activity.

  3. LH3-mediated glucosylation occurs at the specific molecular loci in the type I collagen molecule and plays critical roles in controlling collagen cross-linking, fibrillogenesis, and mineralization.

  4. the major function of LH3 in osteoblasts is to glucosylate galactosylhydroxylysine residues in type I collagen and that an impairment of this LH3 function significantly affects type I collagen fibrillogenesis.

  5. results demonstrate that LH3 is indispensable for biosynthesis of type IV collagen (show COL4 Proteins) and for basement membrane stability during early development and that loss of LH3's functions leads to embryonic lethality

  6. LH3 is present and active in the extracellular space

  7. LH3 has lysyl hydroxylase and galactosylhydroxylysyl glucosyltransferase T activities in vivo, and is essential for the formation of the basement membrane

  8. Results report an important role for lysyl hydroxylase 3 in the organization of the extracellular matrix (ECM (show MMRN1 Proteins)) and cytoskeleton.

Human Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 3 (PLOD3) interaction partners

  1. The study shows that lysyl hydroxylase 3 localizes to epidermal basement membrane and is reduced in patients with recessive dystrophic epidermolysis bullosa.

  2. MMP-9 (show MMP9 Proteins) recruitment to the fibroblast cell surface by Lysyl Hydroxylase 3 (LH3) triggers TGF-beta (show TGFB1 Proteins) activation and fibroblast differentiation

  3. LH3 molecules found in the cell medium are secreted through the Golgi complex, and the secretion is dependent on LH3 glycosyltransferase (show GTDC2 Proteins) activity; LH3 found on the cell surface bypasses the Golgi complex

  4. Dimerization of human lysyl hydroxylase 3 is mediated by the amino acids 541-547

  5. Characterization of three fragments that constitute the monomers of the human lysyl hydroxylase isoenzymes 1-3. The 30-kDa N-terminal fragment is not required for lysyl hydroxylase activity

  6. Manipulation of the gene for LH3 can be used to selectively alter glycosylation and hydroxylation reactions, and provides new tool to clarify functions of unique hydroxylysine linked carbohydrates in collagens and other proteins.

  7. LH3 is present and active in the extracellular space

  8. The deficiency of LH3 glycosyltransferase (show GTDC2 Proteins) activities, especially in the extracellular space, causes growth arrest.

  9. mutations of the lysyl hydroxylase 3 gene may cause a connective tissue disorder [case report]

PLOD3 Protein Profile

Protein Summary

The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity.

Gene names and symbols associated with PLOD3

  • procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (plod3)
  • procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (PLOD3)
  • procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (Plod3)
  • AI414586 protein
  • cb479 protein
  • cb816 protein
  • diwanka protein
  • DKFZp469I0226 protein
  • im:6912725 protein
  • LH3 protein
  • plod protein
  • PLOD3 protein
  • wu:fb72f10 protein

Protein level used designations for PLOD3

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 , procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 , diw , lh3 , procollagen-lysine,2-oxoglutarate 5-dioxygenase 3-like , lysyl hydroxylase 2 , lysyl hydroxylase 3 , LH3 , bone protein I (BP-I) , lysine hydroxylase 3 , lysyl hydroxlase 3

GENE ID SPECIES
380138 Xenopus laevis
463618 Pan troglodytes
479730 Canis lupus familiaris
514996 Bos taurus
556077 Danio rerio
734090 Xenopus (Silurana) tropicalis
100059479 Equus caballus
100173058 Pongo abelii
100390092 Callithrix jacchus
26433 Mus musculus
288583 Rattus norvegicus
8985 Homo sapiens
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