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Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed. Additionally we are shipping Prohibitin Kits (40) and Prohibitin Proteins (14) and many more products for this protein.
Showing 10 out of 192 products:
Chicken Monoclonal Prohibitin Primary Antibody for IF, IHC (p) - ABIN180322
McClung, Jupe, Liu, DellOrco: Prohibitin: potential role in senescence, development, and tumor suppression. in Experimental gerontology 1996
Show all 3 references for ABIN180322
Human Polyclonal Prohibitin Primary Antibody for EIA, WB - ABIN357838
Gregory-Bass, Olatinwo, Xu, Matthews, Stiles, Thomas, Liu, Tsang, Thompson: Prohibitin silencing reverses stabilization of mitochondrial integrity and chemoresistance in ovarian cancer cells by increasing their sensitivity to apoptosis. in International journal of cancer. Journal international du cancer 2008
Show all 3 references for ABIN357838
Human Polyclonal Prohibitin Primary Antibody for EIA, WB - ABIN357836
White, Ledbetter, Eddy, Shows, Stewart, Nuell, Friedman, Wood, Owens, McClung: Assignment of the human prohibitin gene (PHB) to chromosome 17 and identification of a DNA polymorphism. in Genomics 1992
Show all 3 references for ABIN357836
Human Monoclonal Prohibitin Primary Antibody for ICC, FACS - ABIN969353
Shi, Li, Liu, Xu, Tang, Liang, Zhao, Yang: Nuclear matrix protein, prohibitin, was down-regulated and translocated from nucleus to cytoplasm during the differentiation of osteosarcoma MG-63 cells induced by ginsenoside Rg1, cinnamic acid, and tanshinone IIA (RCT). in Journal of cellular biochemistry 2009
Show all 2 references for ABIN969353
Human Monoclonal Prohibitin Primary Antibody for WB - ABIN1882051
Sato, Saito, Swensen, Olifant, Wood, Danner, Sakamoto, Takita, Kasumi, Miki: The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer. in Cancer research 1992
Show all 2 references for ABIN1882051
Human Polyclonal Prohibitin Primary Antibody for FACS, IF - ABIN389162
Ross, Nagy, Kirken: The PHB1/2 phosphocomplex is required for mitochondrial homeostasis and survival of human T cells. in The Journal of biological chemistry 2008
Show all 2 references for ABIN389162
Chicken Polyclonal Prohibitin Primary Antibody for IHC, WB - ABIN2777606
Fraering, Ye, Strub, Dolios, LaVoie, Ostaszewski, van Dorsselaer, Wang, Selkoe, Wolfe: Purification and characterization of the human gamma-secretase complex. in Biochemistry 2004
Human Polyclonal Prohibitin Primary Antibody for IF (p), IHC (p) - ABIN686692
Xing, Yuan, Xu, Gu, Liang, Lu: Proteomic identification of mitochondrial targets involved in andrographolide sodium bisulfite-induced nephrotoxicity in a rat model. in Environmental toxicology and pharmacology 2015
We propose a model whereby in analogy to previous findings (e.g., the RAS-RAF (show RAF1 Antibodies) signalling pathway), PHB can act as a signalling scaffold protein (show HOMER1 Antibodies) to assist in KDELR (show KDELR Antibodies)-dependent Src (show SRC Antibodies) activation
a majority of patients with IgG4-related disease have antibodies against prohibitin.
PHB phosphorylated at threonine 258 and MIG-7 (show TOX4 Antibodies) may play complementary roles in the initiation and sustainment of the effects of growth factors and COX-2 (show COX2 Antibodies)/PGE2 on cancer invasion/metastasis.
miR (show MLXIP Antibodies)-27a was shown to be a significant tumor suppressor by targeting and decreasing PHB protein expression in glioma U251 cells. miR (show MLXIP Antibodies)-27a targeting of PHB may be a novel potential therapeutic strategy for glioma
Less expression of prohibitin is associated with increased paired box 2 (show PAX2 Antibodies) in renal interstitial fibrosis
A protective role of PHB that is dependent on pS727-Stat3 (show STAT3 Antibodies) to prevent mitochondrial dysfunction in intestinal epithelial cells.
Knockdown of prohibitin expression promotes glucose metabolism in eutopic endometrial stromal cells from women with endometriosis.
we have provided a modified method for isolating and identifying membrane proteins and demonstrated that PHB1 may be a promising biomarker for early diagnosis and therapy of pancreatic (and potentially other) cancers.
PHB lies downstream of ERalpha (show ESR1 Antibodies) and mediates estrogen-dependent Paclitaxel resistance signaling cascades
The study suggest that the tumor suppressing action of prohibitin is probably associated with luteinizing hormone mediated protection role against ovarian epithelial carcinoma.
Study shows that PHB is highly expressed in white adipose tissue and liver which expression is regulated by estrogen.
This study identifies a novel signaling pathway composed of miR (show MLXIP Antibodies)-361 and PHB1 that regulates mitochondrial fission program and apoptosis.
Both c-Myc (show MYC Antibodies) and PHB1 directly interact with Nrf2 (show NFE2L2 Antibodies) but c-Myc (show MYC Antibodies) lowers Nrf2 (show NFE2L2 Antibodies) binding to antioxidant response elemens while PHB1 enhances it.
A role for PHB in GnRH-induced cell death in mature gonadotropes, which is crucial for the normal development and function of the reproductive axis.
Data indicate that phosphorylation of Tyr114 and Tyr259 of prohibitin (PHB) is critical for the association of PHB with FcRI (show FCGR1A Antibodies) and Syk (show SYK Antibodies).
maintaining expression of intestinal epithelial cell prohibitin reduces the severity of inflammation and increases colonic levels of the antioxidants HO-1 (show HMOX1 Antibodies) and NQO-1 (show NQO1 Antibodies) via a mechanism independent of Nfe2 (show NFE2 Antibodies)
Phb1/2 and the CD86 (show CD86 Antibodies) cytoplasmic domain cooperate to mediate CD86 (show CD86 Antibodies) signaling in a B cell through differential phosphorylation of distal signaling intermediates required to increase IgG1.
Findings suggest that PHB protects against colitis-associated cancer by modulating p53 (show TP53 Antibodies)- and STAT3 (show STAT3 Antibodies)-mediated apoptosis.
Phb1 deficiency is a potential driver of chronic liver diseases by inducing hepatocyte damage and inflammation.
Identified PHB as an important protein in adipocyte differentiation. Furthermore, the overexpression of PHB in 3T3-L1 fibroblasts was sufficient to induce adipogenesis.
Data show that protein-tyrosine phosphatase (show ACP1 Antibodies) PRP4A3 (prl3 (show PTP4A3 Antibodies)) and van gogh like1 (vangl1 (show Vangl1 Antibodies)) are Necessary Components in prohibitin1 (phb1) dependent neural crest specification.
Xphb1 represses E2F1 (show E2F1 Antibodies) activity.
Prohibitin is involved in oxidative stress signaling in the retina and retinal pigment epithelium.
Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.
, prohibitin protein Wph
, B-cell receptor-associated protein 32