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secretory protein localized to acinar cells of neonatal and adult submandibular and parotid glands, also expressed in sublingual glands [RGD, Feb 2006].. Additionally we are shipping PIP Antibodies (196) and PIP Kits (31) and many more products for this protein.
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Recent work with Pip-deficient mice, linking PIP not only to a role in innate immunity but for the first time, providing evidence for a role in cell-mediated immunity. [Review]
The findings implicate PIP as an important regulator of CD4 (show CD4 Proteins)(+) Th1 (show HAND1 Proteins)-cell-mediated immunity.
these studies lend support to an immunomodulatory role for PIP in vivo and provide further insights into potentially novel signaling pathways and regulatory networks for PIP
examined the endogenous pattern of mouse SMGP/PIP (mSMGP/mPIP) gene expression in mid-and late-embryonic, and in early postnatal development
good coincidence was observed between primary and metastatic tumor GATA3 (show GATA3 Proteins) expression (kappa value = 0.826 >0.75) as compared with the coincidence of GCDFP15 (kappa value =0.492 <0.75) and mammaglobin (kappa value =0.593 <0.75)
High expression of GCDFP-15 is associated with molecular apocrine breast cancer.
While highly expressed under pathological conditions of the mammary gland, including breast cancers, PIP is expressed in very few other cancers. Although the function of PIP is not well elucidated, numerous studies suggest that its primary role may be related to host defense and immune modulation. Studies in Pip null mice suggest that PIP may play a similar immune-regulatory role in breast cancer. [Review]
novel marker GATA3 (show GATA3 Proteins) stains a significantly higher proportion of both primary and metastatic breast carcinomas than GCDFP15 or mammaglobin with stronger and more diffuse staining, helpful in cases with small tissue samples
In summary, this study suggests that PIP expression regulates the process of cell adhesion in breast cancer.
GCDFP15 in stratum corneum is a potential marker for dysregulated sweating in atopic dermatitis.
The commonly used breast carcinoma biomarkers vary in their prognostic implications. GCDFP-15 independently indicated a favourable prognosis. GATA-3 (show GATA3 Proteins) and MGB were not associated with outcome.
Data indicate the potential role of Gross cystic disease fluid protein-15/prolactin-inducible protein (GCDFP-15/PIP) as a biomarker for keratoconus (KC)disease.
Prolactin-induced protein mediates cell invasion and regulates integrin signaling in estrogen receptor (show ESR1 Proteins)-negative breast cancer.
GCDFP-15 expression is higher in tumors with favorable prognostic features. GCDFP-15 expression is further a frequent feature of androgen receptor (show AR Proteins) positive tumors and the molecular apocrine subtype.
secretory protein localized to acinar cells of neonatal and adult submandibular and parotid glands, also expressed in sublingual glands
prolactin inducible protein
, prolactin-induced protein
, prolactin-inducible protein homolog
, 14 kDa submandibular gland protein
, gross cystic disease fluid protein 15
, prolactin-inducible protein
, secretory actin-binding protein