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Proline-Rich Transmembrane Protein 2 Proteins (PRRT2)

PRRT2 encodes a transmembrane protein containing a proline-rich domain in its N-terminal half. Additionally we are shipping PRRT2 Antibodies (25) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PRRT2 112476 Q7Z6L0
PRRT2 69017  
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Top PRRT2 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$388.93
Details

PRRT2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Proline-Rich Transmembrane Protein 2 (PRRT2) Interaction Partners

Human Proline-Rich Transmembrane Protein 2 (PRRT2) interaction partners

  1. In this study, 20 probands with BPEI were negative for family history of BPEI and negative for PRRT2 mutation.

  2. a novel intronic PRRT2 mutation causes paroxysmal kinesigenic dyskinesia with infantile convulsions

  3. comprehensive review of PRRT2-associated diseases.

  4. study highlights the frequency, novel mutations and clinical and molecular spectrum of PRRT2, SLC2A1 and PNKD mutations as well as the phenotype-genotype overlap among these paroxysmal movement disorders.

  5. 649dupC frameshift mutation of the PRRT2 gene is associated paroxysmal kinesigenic dyskinesia.

  6. mutant PRRT2, probably through its weakened interaction with SNAP25 (show SNAP25 Proteins), affects glutamate (show GRIN1 Proteins) signaling and glutamate (show GRIN1 Proteins) receptor activity, resulting in the increase of glutamate (show GRIN1 Proteins) release and subsequent neuronal hyperexcitability.

  7. PRRT2 mutations are common in patients with paroxysmal kinesigenic dyskinesia (PKD (show PRKD1 Proteins)) and are associated with an earlier age at onset, longer duration of attacks, combined phenotypes of dystonia and chorea, and a tendency for a family history of PKD (show PRKD1 Proteins).

  8. investigated sequences of PRRT2 and CLCN1 (show CLCN1 Proteins) in a proband diagnosed with paroxysmal kinesigenic dyskinesia and suspected myotonia congenita; the proband and his father harbored a PRRT2 c.649dupC mutation, and CLCN1 (show CLCN1 Proteins) c.1723C>T and c.2492A>G mutations; first report showing the coexistence of PRRT2 and CLCN1 (show CLCN1 Proteins) mutations

  9. The results of this study suggest that the NMD of truncated mutation of PRRT2 and altered cellular localization of undegraded of PRRT2, might lead to Paroxysmal Kinesigenic.

  10. PRRT2 variants were probably involved in the etiology of febrile seizures in epileptic patients.

Mouse (Murine) Proline-Rich Transmembrane Protein 2 (PRRT2) interaction partners

  1. PRRT2 interacts with the Src (show SRC Proteins) homology 3 domain-bearing protein Intersectin 1, an intracellular protein (show CKAP2 Proteins) involved in synaptic vesicle cycling.

  2. Mutants associated with paroxysmal kinesigenic dyskinesia with infantile convulsions C lead to dramatically reduced PRRT2 levels.

PRRT2 Protein Profile

Protein Summary

This gene encodes a transmembrane protein containing a proline-rich domain in its N-terminal half. Studies in mice suggest that it is predominantly expressed in brain and spinal cord in embryonic and postnatal stages. Mutations in this gene are associated with episodic kinesigenic dyskinesia-1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PRRT2

  • proline-rich transmembrane protein 2 (PRRT2)
  • proline-rich transmembrane protein 2 (Prrt2)
  • 1500031I19Rik protein
  • AI195361 protein
  • BFIC2 protein
  • BFIS2 protein
  • DSPB3 protein
  • DYT10 protein
  • EKD1 protein
  • ICCA protein
  • IFITMD1 protein
  • PKC protein

Protein level used designations for PRRT2

dispanin subfamily B member 3 , interferon induced transmembrane protein domain containing 1

GENE ID SPECIES
112476 Homo sapiens
69017 Mus musculus
100444066 Pongo abelii
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