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Propionyl CoA Carboxylase, alpha Polypeptide Proteins (PCCA)

The protein encoded by PCCA is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. Additionally we are shipping PCCA Antibodies (32) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PCCA 5095 P05165
PCCA 687008 P14882
PCCA 110821 Q91ZA3
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Top PCCA Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,965.50
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PCCA Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

Mouse (Murine)

More Proteins for Propionyl CoA Carboxylase, alpha Polypeptide (PCCA) Interaction Partners

Human Propionyl CoA Carboxylase, alpha Polypeptide (PCCA) interaction partners

  1. Ten propionic acidemia mutations were confirmed, including 8 affecting the PCCA gene and 2 affecting the PCCB (show PCCB Proteins) gene

  2. Two PCCA mutations, c.229C-->T (p.R77W) and c.1262A-->C (p.Q421P), were identified in a PCCA-deficient patient.

  3. Mutation analysis of the PCCA gene identified homozygous c.1284+1G>A in patient 1, c.230G>A (p.R77Q) and c.1855C>T (p.R619X) in patient 2, homozygous c.2125T>C (p.S709P) in patient 3, and only one mutant allele, c.231+1G>T in patient 4.

  4. Thsi study presented that Propionic acidemia(PCCA mutation) associated with visual hallucinations

  5. propionyl CoA carboxylase alpha polypeptide intronic variations causing aberrantly spliced messenger RNA is associated with propionic and methylmalonic acidemia.

  6. pathogenicity of 11 mutations by expression studies and correlation of genotype-phenotype in PCCA-deficient propionic acidemia patients.

  7. Data reported 9 novel PCCA gene mutations and represents an extensive update of the mutational study of propionic acidemia providing important information about the worldwide distribution of PA mutations.

  8. analysis of propionyl-CoA carboxylase containing pathogenic mutations in the beta subunit (show POLG Proteins) (R165W, E168K, and R410W) and one PCCB (show PCCB Proteins) polymorphism (A497V) and their structural and functional effects

  9. analysis of PCCA and PCCB (show PCCB Proteins) mutations in propionic acidemia

  10. This work describes for the first time the high frequency of large genomic deletions in the PCCA gene, which could be due to the characteristics of the PCCA gene structure and its abundance in intronic repetitive elements.

Mouse (Murine) Propionyl CoA Carboxylase, alpha Polypeptide (PCCA) interaction partners

  1. A single intravenous injection of adeno (show ADORA2A Proteins)-associated virus 2/8 or AAVrh10 expressing PCCA into propionic academia hypomorphic mice decreased systemic propionylcarnitine and methyl citrate for up to 1.5 years.

PCCA Protein Profile

Protein Summary

The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PCCA

  • propionyl-COA carboxylase alpha chain, mitochondrial (BMEI0800)
  • propionyl-CoA carboxylase alpha chain (bccA)
  • propionyl-CoA carboxylase alpha chain (pccA)
  • propionyl-CoA carboxylase alpha chain (NRI_0781)
  • propionyl CoA carboxylase, alpha polypeptide (PCCA)
  • propionyl CoA carboxylase, alpha polypeptide (pcca)
  • propionyl CoA carboxylase, alpha polypeptide (Pcca)
  • propionyl-Coenzyme A carboxylase, alpha polypeptide (pcca)
  • propionyl-Coenzyme A carboxylase, alpha polypeptide (Pcca)
  • C79630 protein
  • wu:fb92g02 protein
  • zgc:100925 protein

Protein level used designations for PCCA

propionyl-COA carboxylase alpha chain, mitochondrial , propionyl-CoA carboxylase alpha chain , PCCase alpha subunit , pccA complementation group , propanoyl-CoA:carbon dioxide ligase alpha subunit , propionyl Coenzyme A carboxylase, alpha polypeptide , propionyl-CoA carboxylase alpha chain, mitochondrial , propionyl-Coenzyme A carboxylase, alpha polypeptide , PCCase subunit alpha , Propionyl Coenzyme A carboxylase alpha polypeptide , propanoyl-CoA:carbon dioxide ligase subunit alpha , propionyl-coenzyme A carboxylase, alpha polypeptide , fb92g02 , propionyl CoA-carboxylase alpha

GENE ID SPECIES
1196511 Brucella melitensis bv. 1 str. 16M
3233474 Ehrlichia ruminantium str. Welgevonden
3261399 Ehrlichia ruminantium str. Welgevonden
3268638 Ehrlichia ruminantium str. Gardel
8220850 Neorickettsia risticii str. Illinois
8651467 Anaplasma centrale str. Israel
8955788 Sphingobium japonicum UT26S
5095 Homo sapiens
734347 Xenopus laevis
614302 Bos taurus
687008 Rattus norvegicus
437019 Danio rerio
110821 Mus musculus
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