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The protein encoded by PTGER1 is a member of the G protein-coupled receptor family. Additionally we are shipping Prostaglandin E Receptor 1 (Subtype EP1), 42kDa Proteins (4) and many more products for this protein.
Showing 10 out of 63 products:
PGE2 serves as a central regulator of the Ren (show REN1 Antibodies)-1c gene in the principal cells of the kidney collecting ducts via the PKC (show PKC Antibodies)/cAMP/CREB (show CREB1 Antibodies) pathway.
Our study identifies the EP1 signaling pathway as an important link between neuroinflammation and MMP-mediated BBB (show ALMS1 Antibodies) breakdown in ischemic stroke.
EP1-/- mice maintain increased bone mineral density and stronger cortical and trabecular bone biomechanical properties with aging. The EP1 receptor acts to inhibit bone marrow osteoprogenitor cell differentiation and mineralization.
Results indicate that EP1 receptor activation during seizures, through a protein kinase C (show PKC Antibodies) pathway, increases probability of kainic acid induced status epilepticus, and independently promotes hippocampal neurodegeneration and a broad inflammatory response
The EP1 receptor facilitates the actions of angiotensin II, thereby suggesting that targeting of both the renin (show REN Antibodies)-angiotensin system and the EP1 receptor could be beneficial in diabetic nephropathy.
Propose a mechanism whereby ANG II (show AGT Antibodies) increases COX-1 (show PTGS1 Antibodies)-derived PGE2 through the AT1R (show AGTRAP Antibodies)/PLA2 (show PLA2G2A Antibodies) pathway, which promotes ROS (show ROS1 Antibodies) production by EP1R/Nox2 (show CYBB Antibodies) signaling in the subfornical organ.
dietary administration and direct injection of the EP1 receptor-specific antagonist, ONO-8713, effectively reduced the growth of established CT26 (show DDX53 Antibodies) tumors in BALB/c mice
EP1 deletion protects mice from asymmetrical Parkinsonism. The PGE2 EP1 receptor is implicated in 6-OHDA-induced Parkinsonism.
Data suggest that EP1 receptor blockade may be a viable target for antihypertensive therapy.
data suggest that the tumor promoting/progressing effects of EP1 require the PGE2 synthesized by COX-2 (show COX2 Antibodies)
COX-2 (show COX2 Antibodies) expression appears to be linked to early hepatocellular carcinoma events (initiation), while EP1 receptor expression may participate in tumor progression and predict survival
Copy number variation in PTGER1 is associated with NSAIDs-induced urticaria and/or angioedema
suppression of EP1 prevented RAMA-induced FasL (show FASL Antibodies) suppression in CLT85 cells at both the mRNA and protein levels
A transient interaction between COX-2 (show COX2 Antibodies) and EP1 constitutes a feedback loop whereby an increase in COX-2 (show COX2 Antibodies) expression elevates EP1.
NF-kappaB (show NFKB1 Antibodies) inhibitor suppressed 17-PT-PGE2-mediated FoxC2 (show FOXC2 Antibodies) upregulation. Immunohistochemistry showed p65 (show GORASP1 Antibodies), FoxC2 (show FOXC2 Antibodies), EP1 receptor and beta1-integrin were all highly expressed in the HCC (show FAM126A Antibodies) cases
COX-1 (show COX1 Antibodies), H446K' is significantly more sensitive to downregulation by EP . Together these data suggest that distinctive ubiquitination of COX-1 (show COX1 Antibodies) and COX-2 (show COX2 Antibodies) may be responsible for their different sensitivity to EP -mediated degradation.
through complex formation with D1, EP1 signaling directs the D1 receptor through G(betagamma) to be coupled to AC7 (show Adcy7 Antibodies).
PGE2-enhanced MMP2 (show MMP2 Antibodies) expression is mediated through EP1 receptors and calcium signaling pathway-induced CREB (show CREB1 Antibodies) phosphorylation in human cholangiocarcinoma cells.
Our study suggests that the PGE (show LIPF Antibodies) EP1 receptor regulates FAK (show PTK2 Antibodies) phosphorylation by activating the PKC (show PRRT2 Antibodies)/c-Src (show SRC Antibodies) and EGFR (show EGFR Antibodies) signal pathways, which may coordinately regulate adhesion and migration in HCC (show FAM126A Antibodies)
PGE (show LIPF Antibodies)(2) -mediated NF-kappaB (show NFKB1 Antibodies) activation by simultaneous stimulation of EP(1) and EP(4 (show PTGER4 Antibodies)) receptors induces maximal IL-8 (show IL8 Antibodies) promoter activation and IL-8 (show IL8 Antibodies) mRNA and protein induction
The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin.
prostaglandin E receptor 1 (subtype EP1), 42kDa
, prostaglandin E2 receptor subtype EP1
, PGE receptor EP1 subtype
, PGE2 receptor EP1 subtype
, prostaglandin E2 receptor EP1 subtype
, prostanoid EP1 receptor
, EP1 prostanoid receptor
, PGE receptor, EP1 subtype
, prostaglandin E receptor EP1 subtype
, prostaglandin E receptor 1, subtype EP1