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The protein encoded by PTGER3 is a member of the G-protein coupled receptor family. Additionally we are shipping Prostaglandin E Receptor 3 (Subtype EP3) Antibodies (114) and Prostaglandin E Receptor 3 (Subtype EP3) Kits (16) and many more products for this protein.
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EP2 (show SPAG11B Proteins) and EP3 receptors are involved in tolerance induction through IL-10 (show IL10 Proteins) production by tol-DCs.
findings show that prostaglandin E2 EP3 receptor contributes to thrombin (show F2 Proteins)-induced brain damage via Rho-Rho kinase (show ROCK1 Proteins)-mediated cytotoxicity and proinflammatory responses.
S211L within EP3 is the key residue to distinguish PGE1 and PGE2 binding to mediate diverse biological functions at the initial recognition step
The present study identified the functions of EP3 and the mechanisms by which PGE2 regulates beta-catenin (show CTNNB1 Proteins) expression and promoted cholangiocarcinoma cell growth and invasion
Our results show that oxLDL suppresses EP3 expression by activation of PPAR-g (show ARF6 Proteins) and subsequent inhibition of NF-kappaB (show NFKB1 Proteins) in macrophages.
results demonstrate that risk of unsuccessful periodontal treatment is associated with tag SNPs in specific genes that regulate the inflammatory response, one of which is also associated with sPTB.
Failure of cervical ripening, after local application of prostaglandins for labor induction, may be caused by the increased expression of EP3 and concomitant decrease in EP4 (show PTGER4 Proteins) expression.
Human prostate cancer is associated with EP4 (show PTGER4 Proteins) and EP2 (show SPAG11B Proteins) overexpression and reduced EP3 expression.
EP3 downregulation contributed to prostate carcinogenesis and to progression from androgen-dependent prostate cancer to castration-resistant prostate cancer by regulating androgen receptor (show AR Proteins) expression.
Neuronal prostaglandin E2 receptor subtype EP3 mediates antinociception during inflammation.
For the mutant receptors, the second extracellular loop (ECII) plays a critical role in linking the agonist bound receptor conformation to the G protein nucleotide bound state.
EP3 receptor and its alpha and gamma isoforms are involved in both adipogenesis and lipolysis and influence food intake, serum lipid levels, and insulin (show INS Proteins) sensitivity.
PGE2 reduces contractility of the in vivo heart, the isolated working heart, and single adult ventricular myocytes via its EP3 receptor.
Activation of the EP3 receptor facilitates sprouting angiogenesis through protein kinase A/beta (show SUCLA2 Proteins)-catenin (show CTNNB1 Proteins)/notch (show NOTCH1 Proteins) signaling.
Data show that prostaglandin E2 receptor EP3 subtype (EP3) was expressed in the interstitial cells of Cajal (ICCs) of the bladder and activated hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.
Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 (show CYSLTR1 Proteins) and E-prostanoid receptor 3
Data (including data from studies in knockout mice) suggest that Ptger3 is involved in regulation of adiposity, lipid metabolism, and insulin (show INS Proteins) resistance; Ptger3 knockout mice gain more weight on high-fat diet than normal mice.
EP3 activation facilitates hypoxia-induced vascular remodeling and pulmonary hypertension in mice.
EP3 and TLR3 (show TLR3 Proteins) in conjunctival epithelium play a critical role in regulating ocular surface inflammation.
PGE2 triggers mast cell activation via an EP3-Gi/o-Ca(2 (show CA2 Proteins)+) influx/PI3K pathway. This mechanism underlies PGE2-induced vascular permeability and consequent edema formation.
Neointimal hyperplasia response to injury is mediated through prostaglndin EP3 receptor.
vasoconstriction is mediated by phosphatidyl-inositol pathway via activation of EP1 (show PTGER1 Proteins)- and EP3-receptors located on the smooth muscle cells
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene.
prostaglandin E2 receptor EP3 subtype
, prostaglandin E receptor 3, subtype EP3
, prostaglandin E receptor 3 (subtype EP3)
, PGE receptor, EP3 subtype
, PGE2 receptor EP3 subtype
, prostaglandin E receotor EP3 subtype 3 isoform
, prostaglandin receptor (PGE-2)
, prostanoid EP3 receptor
, PGE receptor EP3 subtype
, prostaglandin EP3 receptor subtype
, prostaglandin E receptor EP3 subtype
, prostaglandin E2 receptor EP3B subtype
, Prostaglandin E2 receptor EP3 subtype