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anti-Prostaglandin I2 (Prostacyclin) Synthase (PTGIS) Antibodies

PTGIS encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping Prostaglandin I2 (Prostacyclin) Synthase Kits (32) and Prostaglandin I2 (Prostacyclin) Synthase Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PTGIS 19223 O35074
PTGIS 25527 Q62969
PTGIS 5740 Q16647
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Top anti-Prostaglandin I2 (Prostacyclin) Synthase Antibodies at antibodies-online.com

Showing 10 out of 63 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB Formalin-fixed and paraffin-embedded human prostate carcinoma reacted withPTGIS Antibody (C-term) followed which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of PTGIS Antibody (C-term) Cat.-No AP17980PU-N in CEM cell line lysates (35ug/lane). CYP8A1 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Cow Rabbit Un-conjugated IHC (fro), IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Cow Rabbit Un-conjugated IHC (p), IP, WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Mouse Un-conjugated ELISA, WB PTGIS polyclonal antibody (A01), Lot # 050921JC01 Western Blot analysis of PTGIS expression in NIH/3T3 . Western Blot detection against Immunogen (38.21 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-CYP8A1 Antibody (N-term) (ABIN392532) in mouse lung tissue lysates (35 µg/lane). CYP8A1(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with CYP8A1 antibody (N-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of CYP8A1 Antibody (C-term) (ABIN652421) in CEM cell line lysates (35 µg/lane). CYP8A1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human prostate carcinoma reacted with PAX3 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Bat Rabbit Un-conjugated IHC, WB 0.05 mg Log in to see 2 to 3 Days
$481.25
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details

PTGIS Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Prostaglandin I2 (Prostacyclin) Synthase Antibodies

  1. Cow (Bovine) Polyclonal PTGIS Primary Antibody for WB - ABIN2781839 : Ruan, Wu, Cervantes: Characterization of the substrate mimic bound to engineered prostacyclin synthase in solution using high-resolution NMR spectroscopy and mutagenesis: implication of the molecular mechanism in biosynthesis of prostacyclin. in Biochemistry 2008 (PubMed)

  2. Human Polyclonal PTGIS Primary Antibody for ELISA, WB - ABIN562513 : Gurgul-Convey, Hanzelka, Lenzen: Mechanism of prostacyclin-induced potentiation of glucose-induced insulin secretion. in Endocrinology 2012 (PubMed)

  3. Human Polyclonal PTGIS Primary Antibody for EIA, WB - ABIN453611 : Nelson, Zeldin, Hoffman, Maltais, Wain, Nebert: Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. in Pharmacogenetics 2004 (PubMed)

More Antibodies against Prostaglandin I2 (Prostacyclin) Synthase Interaction Partners

Cow (Bovine) Prostaglandin I2 (Prostacyclin) Synthase (PTGIS) interaction partners

Mouse (Murine) Prostaglandin I2 (Prostacyclin) Synthase (PTGIS) interaction partners

  1. Prostacyclin synthase and prostaglandin E synthase (show PTGES Antibodies)-1 cooperatively exacerbate inflammatory reactions but have opposing effects on carcinogenesis.

  2. Cyclooxygenase-2 (show PTGS2 Antibodies)-derived prostacyclin regulates arterial thrombus formation by suppressing tissue factor (show F3 Antibodies) in a sirtuin-1 (show SIRT1 Antibodies)-dependent-manner.

  3. CD40 ligand (show CD40LG Antibodies) might contribute to the initiation and progression of atherosclerosis by increasing activity of prostacyclin synthase.

  4. Sepiapterin not only reversed the effects of high glucose on both angiotensin II-induced relaxation and PGI(2 (show PTGIR Antibodies)) release but also abolished high-glucose-enhanced PGIS nitration.

  5. Alpha(2)-adrenoreceptor activation is required for coupling heart rate to central inspiratory drive during acute hypoxia, and PGI(2 (show PTGIR Antibodies)) is required to enhance the inhibition of sympathoactivation.

  6. The results provide strong evidence that the protective effects of COX-2 (show COX2 Antibodies) within the liver are mediated through the production of PGE (show LIPF Antibodies)(2) and PGI(2 (show PTGIR Antibodies)), which exert anti-inflammatory functions.

  7. Endothelial PGI (show BGN Antibodies) synthase-mediated prostacyclin contributes to renal protection against endotoxemia-related acute kidney injury.

  8. identify PGI(2)-prostaglandin I2 receptor (show PTGIR Antibodies) as an important pathway for inhibiting allergic pulmonary inflammation by controlling recruitment of CD4 (show CD4 Antibodies)(+) Th2 cells into the inflammatory site

  9. COX-1 (show PTGS1 Antibodies) contributes to the enhanced formation of both PGI(2 (show PTGIR Antibodies)) and TXA(2 (show TBXA2R Antibodies)) in atherosclerosis, and to the development of the disease

  10. PGIS/ IP transgenic animals with lung-specific PPARgamma (show PPARG Antibodies) overexpression also developed fewer lung tumors.

Human Prostaglandin I2 (Prostacyclin) Synthase (PTGIS) interaction partners

  1. In examining the tumor suppressor PTGIS as a potential biomarker for treatment with either 5-Aza-dC or TSA (show PRDX2 Antibodies), 5-Aza-dC effectively stabilized cell cycling, restricted genetic instability and derepressed PTGIS expression

  2. Based on the predicted crystal structure of CYP8A1( *)5 using the Molecular Operating Environment platform, the distance from CYP8A1 Cys441 to the heme was altered with a significantly changed binding free energy for the mutant protein.

  3. results indicate that PGIS expression was associated with radiotherapy efficiency

  4. Type-2 diabetes is associated with higher COX-2 (show COX2 Antibodies) expression, but lower eNOS (show NOS3 Antibodies) and PGIS expression in subcutaneous arteries.

  5. In a case-control study unaffected carriers of a BMPR2 mutation, linked to pulmonary artery hypertension (PAH), were most often found to have prostacyclin synthase promoter sequence variants, which were thought to protect against PAH.

  6. These findings suggest that PGIS is induced by hypoxia and regulates the expression of VEGF in fibroblasts.

  7. High PTGIS expression is associated with colorectal cancer hepatic metastasis.

  8. The CC genotype of C1117A polymorphism is associated with higher risk of LM-CAD (show CAD Antibodies)

  9. Overexpression of PTGIS is associated with liver metastasis in colon cancer.

  10. diabetes preferentially increases PGIS nitration that is associated with excessive vascular inflammation in atherosclerotic carotid arteries from patients with type 2 diabetes

Zebrafish Prostaglandin I2 (Prostacyclin) Synthase (PTGIS) interaction partners

  1. crystal structures of ligand-free, inhibitor (minoxidil)-bound and substrate analog U51605-bound PGIS

Pig (Porcine) Prostaglandin I2 (Prostacyclin) Synthase (PTGIS) interaction partners

  1. Disturbances in prostacyclin synthase and its receptor may lead to disruption of the oviductal environment and, in turn, perturbed development of embryos and their transport to the uterus.

  2. Prostacyclin synthase is differentially expressed in the endometrium of cyclic and pregnant gilts resulting in higher PGI(2 (show PTGIR Antibodies)) synthesis in pregnant animals

  3. CRP (show CRP Antibodies) stimulates superoxide production and the subsequent formation of peroxynitrite from basal released nitric oxide compromises PGI(2 (show PTGIR Antibodies)) synthesis.

Prostaglandin I2 (Prostacyclin) Synthase (PTGIS) Antigen Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.

Gene names and symbols associated with PTGIS

  • prostacyclin synthase (VDBG_06319) antibody
  • prostaglandin I2 (prostacyclin) synthase (PTGIS) antibody
  • prostaglandin I2 (prostacyclin) synthase (Ptgis) antibody
  • prostaglandin I2 (prostacyclin) synthase (ptgis) antibody
  • CYP8 antibody
  • CYP8A1 antibody
  • PGIS antibody
  • PTGI antibody
  • PTGIS antibody
  • ptgisl antibody

Protein level used designations for PTGIS

prostacyclin synthase , prostaglandin I2 (prostacyclin) synthase , prostaglandin I2 synthase , cytochrome P450, family 8, subfamily A, polypeptide 1 , prostaglandin I2 (prostacyclin) synthase like , cytochrome P450 8A1

GENE ID SPECIES
9535224 Verticillium alfalfae VaMs.102
458323 Pan troglodytes
485919 Canis lupus familiaris
703407 Macaca mulatta
100592236 Nomascus leucogenys
282021 Bos taurus
101116418 Ovis aries
19223 Mus musculus
25527 Rattus norvegicus
100734621 Cavia porcellus
5740 Homo sapiens
559148 Danio rerio
100126284 Sus scrofa
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