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PTGIS encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping Prostaglandin I2 (Prostacyclin) Synthase Kits (26) and Prostaglandin I2 (Prostacyclin) Synthase Proteins (8) and many more products for this protein.
Showing 10 out of 67 products:
Cow (Bovine) Polyclonal PTGIS Primary Antibody for WB - ABIN2781839
Ruan, Wu, Cervantes: Characterization of the substrate mimic bound to engineered prostacyclin synthase in solution using high-resolution NMR spectroscopy and mutagenesis: implication of the molecular mechanism in biosynthesis of prostacyclin. in Biochemistry 2008
Human Polyclonal PTGIS Primary Antibody for EIA, WB - ABIN453611
Nelson, Zeldin, Hoffman, Maltais, Wain, Nebert: Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. in Pharmacogenetics 2004
Human Polyclonal PTGIS Primary Antibody for ELISA, WB - ABIN562513
Gurgul-Convey, Hanzelka, Lenzen: Mechanism of prostacyclin-induced potentiation of glucose-induced insulin secretion. in Endocrinology 2012
Prostacyclin synthase and prostaglandin E synthase (show PTGES Antibodies)-1 cooperatively exacerbate inflammatory reactions but have opposing effects on carcinogenesis.
Cyclooxygenase-2 (show PTGS2 Antibodies)-derived prostacyclin regulates arterial thrombus formation by suppressing tissue factor (show F3 Antibodies) in a sirtuin-1 (show SIRT1 Antibodies)-dependent-manner.
CD40 ligand (show CD40LG Antibodies) might contribute to the initiation and progression of atherosclerosis by increasing activity of prostacyclin synthase.
Sepiapterin not only reversed the effects of high glucose on both angiotensin II-induced relaxation and PGI(2 (show PTGIR Antibodies)) release but also abolished high-glucose-enhanced PGIS nitration.
Alpha(2)-adrenoreceptor activation is required for coupling heart rate to central inspiratory drive during acute hypoxia, and PGI(2 (show PTGIR Antibodies)) is required to enhance the inhibition of sympathoactivation.
The results provide strong evidence that the protective effects of COX-2 (show COX2 Antibodies) within the liver are mediated through the production of PGE (show LIPF Antibodies)(2) and PGI(2 (show PTGIR Antibodies)), which exert anti-inflammatory functions.
Endothelial PGI (show BGN Antibodies) synthase-mediated prostacyclin contributes to renal protection against endotoxemia-related acute kidney injury.
identify PGI(2)-prostaglandin I2 receptor (show PTGIR Antibodies) as an important pathway for inhibiting allergic pulmonary inflammation by controlling recruitment of CD4 (show CD4 Antibodies)(+) Th2 cells into the inflammatory site
COX-1 (show PTGS1 Antibodies) contributes to the enhanced formation of both PGI(2 (show PTGIR Antibodies)) and TXA(2 (show TBXA2R Antibodies)) in atherosclerosis, and to the development of the disease
PGIS/ IP transgenic animals with lung-specific PPARgamma (show PPARG Antibodies) overexpression also developed fewer lung tumors.
In examining the tumor suppressor PTGIS as a potential biomarker for treatment with either 5-Aza-dC or TSA (show PRDX2 Antibodies), 5-Aza-dC effectively stabilized cell cycling, restricted genetic instability and derepressed PTGIS expression
Based on the predicted crystal structure of CYP8A1( *)5 using the Molecular Operating Environment platform, the distance from CYP8A1 Cys441 to the heme was altered with a significantly changed binding free energy for the mutant protein.
results indicate that PGIS expression was associated with radiotherapy efficiency
Type-2 diabetes is associated with higher COX-2 (show COX2 Antibodies) expression, but lower eNOS (show NOS3 Antibodies) and PGIS expression in subcutaneous arteries.
In a case-control study unaffected carriers of a BMPR2 mutation, linked to pulmonary artery hypertension (PAH), were most often found to have prostacyclin synthase promoter sequence variants, which were thought to protect against PAH.
These findings suggest that PGIS is induced by hypoxia and regulates the expression of VEGF in fibroblasts.
High PTGIS expression is associated with colorectal cancer hepatic metastasis.
The CC genotype of C1117A polymorphism is associated with higher risk of LM-CAD (show CAD Antibodies)
Overexpression of PTGIS is associated with liver metastasis in colon cancer.
diabetes preferentially increases PGIS nitration that is associated with excessive vascular inflammation in atherosclerotic carotid arteries from patients with type 2 diabetes
crystal structures of ligand-free, inhibitor (minoxidil)-bound and substrate analog U51605-bound PGIS
Disturbances in prostacyclin synthase and its receptor may lead to disruption of the oviductal environment and, in turn, perturbed development of embryos and their transport to the uterus.
Prostacyclin synthase is differentially expressed in the endometrium of cyclic and pregnant gilts resulting in higher PGI(2 (show PTGIR Antibodies)) synthesis in pregnant animals
CRP (show CRP Antibodies) stimulates superoxide production and the subsequent formation of peroxynitrite from basal released nitric oxide compromises PGI(2 (show PTGIR Antibodies)) synthesis.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.
, prostaglandin I2 (prostacyclin) synthase
, prostaglandin I2 synthase
, cytochrome P450, family 8, subfamily A, polypeptide 1
, prostaglandin I2 (prostacyclin) synthase like
, cytochrome P450 8A1