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PRSS12 encodes a member of the trypsin family of serine proteases. Additionally we are shipping Protease, serine, 12 (Neurotrypsin, Motopsin) Antibodies (29) and Protease, serine, 12 (Neurotrypsin, Motopsin) Proteins (6) and many more products for this protein.
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4-base pair deletion in the neurotrypsin gene was associated with autosomal recessive nonsyndromic mental retardation; findings suggest that neurotrypsin-mediated proteolysis is required for normal synaptic function
This study identifies Tequila and neurotrypsin as new genes repressed by presenilins and reveals a novel mechanism used by presenilins to modulate CREB (show CREB1 ELISA Kits) signaling based on controlling CREB (show CREB1 ELISA Kits) recruitment.
co-expression of sez-6 with motopsin restored the effect of motopsin at the basal level, while sez-6 expression alone showed no effects on cell morphology. Our results suggest that the interaction of motopsin and sez-6 modulates neuronal cell morphology
Our results indicate that an extracellular protease, motopsin, preferentially affects social behaviors, and modulates the functions of hippocampal neurons.
motopsin has multiple functions, such as axon outgrowth, arranging perineuronal environment, and maintaining neuronal plasticity, partly in coordination with other proteases including tissue plasminogen activator (show PLAT ELISA Kits).
neurotrypsin exclusively cleaves glycanated variants of agrin (show AGRN ELISA Kits); neurotrypsin-dependent cleavage of agrin (show AGRN ELISA Kits) was concentrated at synapses, where the most heavily glycanated variants of agrin (show AGRN ELISA Kits) predominate
Detailed analyses indicated that presynaptic action potential firing is necessary for the release of neurotrypsin, whereas postsynaptic NMDA receptor activation is necessary for the neurotrypsin-dependent cleavage of agrin (show AGRN ELISA Kits).
This gene encodes a member of the trypsin family of serine proteases. Studies in mouse suggest that the encoded enzyme may be involved in structural reorganizations associated with learning and memory. The enzyme is also expressed in Leydig cells in the testis, but its function in this tissue is unknown. Defects in this gene are a cause of mental retardation autosomal recessive type 1 (MRT1).
protease, serine, 12 (neurotrypsin, motopsin)
, 26S proteasome regulatory SU
, brain-specific serine protease 3
, serine protease 12
, peptidase, serine, 12 (neurotrypsin, motopsin)