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PRSS8 encodes a trypsinogen, which is a member of the trypsin family of serine proteases. Additionally we are shipping Protease, serine, 8 Antibodies (89) and Protease, serine, 8 Kits (25) and many more products for this protein.
Showing 10 out of 15 products:
Human PRSS8 Protein expressed in Human Cells - ABIN2002505
Yu, Chao, Chao: Prostasin is a novel human serine proteinase from seminal fluid. Purification, tissue distribution, and localization in prostate gland. in The Journal of biological chemistry 1994
Show all 4 references for ABIN2002505
Mouse (Murine) PRSS8 Protein expressed in Baculovirus infected Insect Cells - ABIN2007353
Chen, Skinner, Kauffman, Chao, Chao, Thaler, Chai: Prostasin is a glycosylphosphatidylinositol-anchored active serine protease. in The Journal of biological chemistry 2001
Show all 3 references for ABIN2007353
Human PRSS8 Protein expressed in Wheat germ - ABIN1316486
Svenningsen, Uhrenholt, Palarasah, Skjødt, Jensen, Skøtt: Prostasin-dependent activation of epithelial Na+ channels by low plasmin concentrations. in American journal of physiology. Regulatory, integrative and comparative physiology 2009
PRSS8 may serve as a tumour suppressor in hepatocellular carcinoma progression.
Overexpression of PRSS8 mRNA and high levels of prostasin in multiple subtypes of early stage ovarian tumors may provide clinical biomarkers for early detection of ovarian cancer.
It is concluded that prostasin protein level change is less likely to be causally involved in placental dysfunction in preeclampsia.
In urinary exosomes, NCC (show SLC12A3 Proteins) and prostasin had a diurnal pattern parallel to ADH (show AVP Proteins) and aquaporin 2 (show AQP2 Proteins), confirming that, in healthy subjects, both prostasin and NCC (show SLC12A3 Proteins) relate to water balance.
Polymorphism of the prostasin gene is closely associated with poor pregnancy outcomes of early-onset severe preeclampsia.
Prostasin regulate the Lin28 (show LIN28A Proteins)/Let-7 loop in ovarian cancer cells.
The higher frequency of C allele of prostasin gene at rs12597511 is associated with severe preeclampsia.
Prostasin repress cancer cells and contribute to chemoresistance by modulating the CASP (show CUX1 Proteins)/PAK2-p34 (show PAK2 Proteins)/actin pathway.
Our study suggested that Axl (show AXL Proteins) and prostasin expression may be closely related to carcinogenesis, metastasis, and prognosis of ovarian adenocarcinoma.
urinary prostasin correlates with the aldosterone to renin (show REN Proteins) ratio, and it is physiologically modulated by natriuresis in normotensive individuals
a proteolysis-dependent function of activated prostasin in hair follicles, dependent on zymogen conversion by matriptase (show ST14 Proteins).
The claudin-4 (show CLDN4 Proteins)-mediated chloride conductance can be regulated endogenously by a protease-channel-activating protease 1 (cap1).
HAI-1 (show SPINT1 Proteins) regulates the activity of activated matriptase (show ST14 Proteins), whereas HAI-2 (show SPINT2 Proteins) has an essential role in regulating prostasin-dependent matriptase (show ST14 Proteins) zymogen activation.
a novel inhibitory interaction between CAP1/Prss8 and nexin-1 (show SERPINE2 Proteins), opening the search for specific CAP1/Prss8 antagonists that are independent of its catalytic activity
Data indicate that liver-specific serine protease (show F2 Proteins) prostasin (PRSS8) knockout (LKO) mice develop insulin (show INS Proteins) resistance associated with the increase in hepatic Toll-like receptor 4 (TLR4 (show TLR4 Proteins)).
Data indicate that serine protease (show F2 Proteins) prostasin (CAP1/PRSS8) supports terminal epidermal differentiation through a non-catalytic mechanism.
mutations in Prss8 restored placentation and normal development of HAI-1 (show SPINT1 Proteins)-deficient embryos and prevented early embryonic lethality, mid-gestation lethality due to placental labyrinth failure, and neural tube defects in HAI-2 (show SPINT2 Proteins)-deficient embryos.
Mutations of the serine protease (show F2 Proteins) CAP1/Prss8 lead to reduced embryonic viability, skin defects, and decreased ENaC (show SCNN1A Proteins) activity.
The T to A mutation at residue 170 (Val to Asp (show C3 Proteins)) in Prss8 is responsible for the mutant frizzy (fr) phenotype.
Deficiency of CAP1/Prss8 in alveolar epithelial cells induced in vitro a 40% decrease in epithelial sodium channel-mediated sodium currents.
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of lysine or arginine.
channel-activating protease 1
, serine protease 8
, channel activating protease 1