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Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. Additionally we are shipping and Proteasome-Associated Protein ECM29 Homolog Proteins (1) and many more products for this protein.
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Human Polyclonal KIAA0368 Primary Antibody for IHC - ABIN966026
Ohara, Ohara, Yamakawa, Nakajima, Nakayama: Characterization of a new beta-spectrin gene which is predominantly expressed in brain. in Brain research. Molecular brain research 1998
Show all 3 Pubmed References
Data suggest that the adapter protein (show TOLLIP Antibodies) ECM29 is the main proteasome-interacting protein responsible for oxidative stress-induced (show SQSTM1 Antibodies) proteasome disassembly/remodeling; ECM29 appears to intrude on interaction between the 20S core particle and 19S regulatory particle in 26S proteasome (show Psmd4 Antibodies), disrupting proteasome structure in response to oxidative stress.
Ecm29 is involved in the dissociation process of 26S proteasome (show Psmd4 Antibodies), providing clue to analyse the mechanism of proteasomal degradation under various stress condition.
The absence of Ecm29 enhanced TLR3 (show TLR3 Antibodies) signaling, which was characterized by the increased abundance of the adaptor protein and E3 ubiquitin ligase (show MUL1 Antibodies) tumor necrosis factor (show TNF Antibodies) receptor-associated factor 3
Ecm29 serves as an adaptor for coupling 26 S proteasomes to specific cellular compartments.
Ecm29 protein serves to couple the 26 S proteasome to secretory compartments engaged in quality control and to other sites of enhanced proteolysis
Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolyis (By similarity).
proteasome-associated protein ECM29 homolog
, Proteasome-associated protein ECM29 homolog
, ECM29 homolog, proteasome accessory protein
, homolog of yeast Ecm29