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Protein AF-10 (MLLT10) ELISA Kits

MLLT10 encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Additionally we are shipping MLLT10 Antibodies (73) and MLLT10 Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
MLLT10 8028 P55197
MLLT10 17354 O54826
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Top MLLT10 ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human
96 Tests Log in to see 6 Days
$528.57
Details

More ELISA Kits for MLLT10 Interaction Partners

Human Protein AF-10 (MLLT10) interaction partners

  1. The PZP domain of AF10 senses unmodified H3K27 to regulate DOT1L-mediated methylation of H3K79.

  2. we report that variants at the MLLT10 locus are unlikely to alter risk of glioma, and they have no prognostic value among patients with high-grade tumors (glioblastoma).

  3. Results provide evidence that transformation driven by MLL fusions as well as the recurrent AML-associated NUP98-NSD1 fusion oncogene is critically dependent on the ability of AF10 to stimulate DOT1L activity.

  4. detection of PICALM (show PICALM ELISA Kits)-MLLT10 fusion transcript occurs in 7% of children with T-lineage ALL and is not associated with a poorer outcome for patients treated with contemporary, intensive chemotherapy

  5. In pediatric T-acute lymphoblastic leukemia, we have identified 2 RNA processing genes, that is, HNRNPH1 (show HNRNPH1 ELISA Kits)/5q35 and DDX3X (show DDX3X ELISA Kits)/Xp11.3 as new MLLT10 fusion partners.

  6. results strongly indicate that the differential regulation of these three genes is not due to the break point effect but as a consequence of the CALM/AF10 fusion gene expression, though the mechanism of regulation is not well understood

  7. In leukemia cells, full-length CALM-AF10 localized to the nucleus with no consistent effect on growth factor endocyctosis, and suppressed histone H3 lysine 79 methylation regardless of the presence of clathrin

  8. a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 x 10(-14)) was identified.

  9. FISH analysis in infant AML (show RUNX1 ELISA Kits)-M5 showed a complex rearrangement between chromosomes 10 and 11, disrupting the MLL (show MLL ELISA Kits) gene, a paracentric inversion of the 11q13-q23 fragment translocated to 10p12. AF10 was the fusion partner gene of MLL (show MLL ELISA Kits) in this rearrangement.

  10. ALL1 (show MLL ELISA Kits) is involved in remodeling, acetylating, deacetylating, and methylating nucleosomes and/or free histones

Mouse (Murine) Protein AF-10 (MLLT10) interaction partners

  1. Results provide evidence that transformation driven by MLL fusions as well as the recurrent AML-associated NUP98-NSD1 fusion oncogene is critically dependent on the ability of AF10 to stimulate DOT1L activity.

  2. During leukemogenesis, CALM-AF10 plays critical roles in the cytoplasm.

  3. In leukemia cells, full-length CALM-AF10 localized to the nucleus with no consistent effect on growth factor endocyctosis, and suppressed histone H3 lysine 79 methylation regardless of the presence of clathrin

  4. further suggest that future approaches to antagonize CALM-AF10-induced transformation should incorporate strategies, which aim at blocking these key domains

  5. conclude that Mllt10/Af10-Dot1l are essential, largely dedicated activators of Wnt (show WNT2 ELISA Kits)-dependent transcription, critical for maintenance of intestinal proliferation and homeostasis

MLLT10 Antigen Profile

Antigen Summary

This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Protein AF-10 (MLLT10) ELISA Kits

  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 (MLLT10) antibody
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 (Mllt10) antibody
  • Af10 antibody
  • B130021D15Rik antibody
  • D630001B22Rik antibody
  • mKIAA4140 antibody

Protein level used designations for Protein AF-10 (MLLT10) ELISA Kits

ALL1-fused gene from chromosome 10 protein , protein AF-10 , type I AF10 protein , type III AF10 protein , type IV AF10 protein , myeloid/lymphoid or mixed lineage-leukemia translocation to 10 homolog

GENE ID SPECIES
8028 Homo sapiens
17354 Mus musculus
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