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The protein encoded by PICK1 contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). Additionally we are shipping PICK1 Proteins (3) and and many more products for this protein.
Ca(2 (show CA2 ELISA Kits)+) influx through ASIC1 (show ACCN2 ELISA Kits) mediates chronic hypoxia and ET-1 (show EDN1 ELISA Kits)-induced NFATc3 (show NFATC3 ELISA Kits) nuclear import and 2) the scaffolding protein PICK1 is necessary for NFATc3 (show NFATC3 ELISA Kits) nuclear import.
a dual role of PICK1 in regulating macrophage polarization
This study demonstrated that d-serine provent the behavioral deficits in adult Pick1 knockout mice.
PICK1 is an important regulator of P2Y6R (show P2RY6 ELISA Kits) expression and microglial phagocytosis.
knocking-out PICK1 gene casts the neuroprotection effect by reducing ASICs current and the calcium transients in OGD (show FGFR1 ELISA Kits)-Rep neuronal cells
ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis.
results indicate that PICK1 is a crucial regulator in glutathione homeostasis and may play important roles in oxidative stress.
In cultured neurons, PICK1 deletion increases surface AMPARs and blocks Abeta42-induced reduction in surface GluA2 (show GRIA2 ELISA Kits).
This study demonstrated that PICK1 functions in vesicle biogenesis and is necessary to maintain normal vesicle numbers and size.
C-terminal domain of ICA69 (show ICA1 ELISA Kits) interacts with PICK1 and acts on trafficking of PICK1-PKCalpha (show PKCa ELISA Kits) complex and cerebellar plasticity.
This study defines a novel mechanism whereby elevated [Ca(2 (show CA2 ELISA Kits)+)] induced by NMDA receptor activation modulates Ago2 (show EIF2C2 ELISA Kits) and miRNA activity via PICK1. Our work suggests a Ca(2 (show CA2 ELISA Kits)+)-dependent process to regulate miRNA activity in neurons in response to the induction of long-term depression.
We propose that PICK1 negatively regulates neoplastic infiltration of astrocytic tumors and that manipulation of PICK1 is an attractive possibility for therapeutic intervention
PICK1 domain ACT links PICK1-associated vesicles to a motility factor, likely myosin, but, contrary to previous reports, PICK1 neither binds nor inhibits Arp2 (show ACTR2 ELISA Kits)/3 complex.
Unlike accessory domains in other BAR domain proteins, the positioning of the PDZ (show INADL ELISA Kits) domains is flexible, enabling PICK1 to perform long-range, dynamic scaffolding of membrane-associated proteins.
Data indicate three principal binding modes can account for protein interacting with C-kinase 1 (PICK1) PDZ (show INADL ELISA Kits) domains binding specificity.
PICK1 promotes Ago2 (show EIF2C2 ELISA Kits) localization at endosomal compartments in neuronal dendrites and inhibits Ago2 (show EIF2C2 ELISA Kits) function in translational repression following neuronal stimulation.
These data indicate that Pick1 is involved in regulating the cell-cell junction in epithelial cells.
Family-based association study failed to observe a statistically significant association for any of the genotyped SNPs in the PICK1 gene and attention-deficit hyperactivity disorder.
PICK1 increases caveolin-mediated endocytosis, ubiquitination and degradation of TGF-beta type I receptor (show TGFBR1 ELISA Kits).
The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.
protein interacting with PRKCA 1
, PRKCA-binding protein
, protein kinase C, alpha binding protein
, protein kinase C-alpha-binding protein
, protein that interacts with C kinase 1
, protein interacting with C kinase 1