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Protein phosphatase-1 (PP1) is a major serine/threonine phosphatase that regulates a variety of cellular functions. Additionally we are shipping PPP1R1C Antibodies (30) and many more products for this protein.
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The data demonstrate a novel role for 8-60hIPP5(m) in the control of G2/M cell cycle progression, a process that involves the activation of ATM (show ATM Proteins)/p53 (show TP53 Proteins)/p21cip1/waf1 (show CDKN1A Proteins)/Cdc2 (show CDK1 Proteins)/ cyclin B1 (show CCNB1 Proteins) pathways.
IPP5 mutations are associated with response to paclitaxel in cervical cancer.
The effect of IPP5 on tumor growth and the underlying molecular mechanisms were investigated by overexpression of IPP5 in HeLa cells, a human cervical carcinoma cell line.
Overexpression of active mutant IPP5 inhibited anchorage-dependent growth and induced apoptosis in HeLa cells, which may be attributed to the up-regulation of p21 (show CDKN1A Proteins), p53 (show TP53 Proteins) and Bcl-2 (show BCL2 Proteins)-antagonist/killer, and down-regulation of Bcl-2 (show BCL2 Proteins) and Bcl-X(L (show BCL2L1 Proteins)).
mitochondrial signaling and ERK (show EPHB2 Proteins) activation may be involved in the I-1c cardioprotective effects against apoptosis induced by prolonged beta-adrenergic stimulation
Protein phosphatase-1 (PP1) is a major serine/threonine phosphatase that regulates a variety of cellular functions. PP1 consists of a catalytic subunit (see PPP1CA\; MIM 176875) and regulatory subunits that determine the subcellular localization of PP1 or regulate its function. PPP1R1C belongs to a group of PP1 inhibitory subunits that are themselves regulated by phosphorylation (Wang et al., 2008
PP1 inhibitor protein 5
, inhibitor-5 of protein phosphatase 1
, protein phosphatase 1 regulatory subunit 1A
, protein phosphatase 1 regulatory subunit 1C