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Regulatory subunit of protein phosphatase 1 (By similarity).. Additionally we are shipping Protein Phosphatase 1, Regulatory Subunit 7 Antibodies (51) and many more products for this protein.
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a Fra-1 (show FOSL1 Proteins)-miR (show MLXIP Proteins)-134 axis drives a positive feedback loop that amplifies ERK (show EPHB2 Proteins)/JNK (show MAPK8 Proteins) signaling and reduces chemosensitivity in ovarian cancer cells.
Mechanistically, the phosphorylation of Sds22 by PLK1 strengthens the binding of Sds22 to PP1 (show PPA1 Proteins) and inhibits the dephosphorylation of Thr (show TRH Proteins)(232) of Aurora B (show AURKB Proteins) to ensure a robust, error-free metaphase-anaphase transition.
there is a second, parallel signalling pathway which triggers the relaxation of the polar cell cortex at mid anaphase--independent of furrow formation, centrosomes and microtubules, pathway depends on PP1 (show PPA1 Proteins) phosphatase and regulatory subunit Sds22
a model in which I3 regulates an SDS22-mediated PP1 (show PPA1 Proteins) activation step in solution that precedes SDS22 dissociation and transfer of PP1 (show PPA1 Proteins) to kinetochores, and which is required for PP1 (show PPA1 Proteins) to efficiently antagonize Aurora B (show AURKB Proteins).
It was shown that Repo-Man and Sds22 contribute to timely Aurora B kinase (show AURKB Proteins) substrate dephosphorylation on anaphase chromatin.
human Sds22 is focally deleted and downregulated in multiple carcinomas, and this downregulation correlates with tumor progression, suggesting that sds22 inactivation may contribute to tumorigenesis and metastatic potential
Sds22 specifically defines protein phosphatase 1 (show PPP1CB Proteins) function and localization in mitosis.
Sds22 and Inhibitor-3 (show PPP1R11 Proteins) form a heterotrimeric complex with PP1 (show PPA1 Proteins), both in cell lysates and after purification. A pool of PP1 (show PPA1 Proteins) is complexly controlled by both Sds22 and Inhibitor-3 (show PPP1R11 Proteins).
Regulatory subunit of protein phosphatase 1 (By similarity).
protein phosphatase 1 regulatory subunit 22
, protein phosphatase 1 regulatory subunit 7
, protein phosphatase-1 regulatory subunit 7
, protein phosphatase 1, regulatory (inhibitor) subunit 7
, protein phosphatase-1 regulatory subunit 7 alpha2
, protein phosphatase-1 regulatory subunit 7 beta1
, protein phosphatase-1 regulatory subunit 7 beta2