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Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. Additionally we are shipping PPP4C Proteins (11) and many more products for this protein.
Showing 10 out of 104 products:
Cow (Bovine) Polyclonal PPP4C Primary Antibody for WB - ABIN2787719
Toyo-oka, Mori, Yano, Shiota, Iwao, Goto, Inagaki, Hiraiwa, Muramatsu, Wynshaw-Boris, Yoshiki, Hirotsune: Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation. in The Journal of cell biology 2008
Human Polyclonal PPP4C Primary Antibody for ELISA, IHC - ABIN4347134
Mourtada-Maarabouni, Williams: Protein phosphatase 4 regulates apoptosis, proliferation and mutation rate of human cells. in Biochimica et biophysica acta 2008
Protein phosphatase 4 cooperates with Smads to promote BMP signaling in dorsoventral patterning of zebrafish embryos
Data show that protein phosphatase 4 catalytic subunit (PP4C) knockdown decreases glioma cell proliferation.
mutual regulatory mechanisms exist between PP4 (show ANXA5 Antibodies) and SAF-A (show HNRNPU Antibodies). Interactions between PP4 (show ANXA5 Antibodies) and SAF-A (show HNRNPU Antibodies) played a role in prometaphase/metaphase transition.
These data suggested a potential role of PP4C in tumor progression.
Stathmin plays an essential role of in Merkel cell polyomavirus small tumor antigen-mediated microtubule destabilization and cell motility and this process is regulated by cellular phosphatase catalytic subunit of protein phosphatase 4.
PP4 (show ANXA5 Antibodies) and Wip1 (show PPM1D Antibodies) are differentially required to counteract the p53 (show TP53 Antibodies)-dependent cell cycle arrest in G1 and G2, by antagonizing early or late p53 (show TP53 Antibodies)-mediated responses, respectively
Results show PP4C as a fostriecin-sensitive phosphatase and demonstrate that the suppression of PP4C triggers mitotic slippage/apoptosis.
Data indicate that the major phosphatase responsible for dephosphorylation of of BAF (show BANF1 Antibodies) Ser (show SIGLEC1 Antibodies)-4 to be protein phosphatase 4 catalytic subunit.
Recombinant gamma-tubulin (show TUBG1 Antibodies) can be phosphorylated by Cdk1 (show CDK1 Antibodies)-cyclin B or Brsk1 (show BRSK1 Antibodies) and dephosphorylated by Ppp4c-R2-R3A in vitro.
PP4c is a key regulator of cortical development that changes the orientation of progenitor division responsible for the transition between symmetric and asymmetric cell division.
Overexpression of PP4C is associated with poor prognosis in patients with stage II pancreatic ductal adenocarcinoma.
T cell-specific ablation of PP4 (show ANXA5 Antibodies) resulted in defective adaptive immunity, impaired T cell homeostatic expansion, and inefficient T cell proliferation.
Data show that protein phosphatase 4 (PP4 (show ANXA5 Antibodies)) is an important regulator in inflammatory related insulin (show INS Antibodies) resistance.
Thus, serine/threonine phosphatase PP4 (show ANXA5 Antibodies) functions as a novel feedback negative regulator of RNA virus-triggered innate immunity.
Taken together, our results establish a novel role for PP4 (show ANXA5 Antibodies) in CSR (show SCARA3 Antibodies), and reveal crucial functions for PP4 (show ANXA5 Antibodies) in the maintenance of genomic stability, GC formation, and B cell-mediated immune responses.
PP4 (show ANXA5 Antibodies) overexpression was observed to lead to a decreased pACC1Ser79/ACC1 (show ACACA Antibodies) ratio and subsequently an increased intracellular triglyceride content in mouse primary hepatocytes.
Mammalian SMEK/PP4C proteins are involved in the regulation of hepatic glucose metabolism through dephosphorylation of CRTC2 (show CRTC2 Antibodies).
Protein phosphatase 4 has a role in apoptosis.
PP4 is essential for thymocyte development and pre-TCR signaling
PP4 (show ANXA5 Antibodies) negatively regulated LPS (show TLR4 Antibodies)-induced and TRAF6 (show TRAF6 Antibodies)-mediated NF-kappaB (show NFKB1 Antibodies) activation by inhibiting the ubiquitination of TRAF6 (show TRAF6 Antibodies).
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
protein phosphatase 4, catalytic subunit
, catalytic subunit
, serine/threonine-protein phosphatase 4 catalytic subunit A
, protein phosphatase 4 (formerly X), catalytic subunit
, protein phosphatase X, catalytic subunit
, serine/threonine-protein phosphatase 4 catalytic subunit
, protein phosphatase X