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Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). Additionally we are shipping Protein Phosphatase 4, Regulatory Subunit 2 Antibodies (43) and Protein Phosphatase 4, Regulatory Subunit 2 Kits (2) and many more products for this protein.
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PPP4R2 affects the survival of neuronal cells in response to DNA damage.
PP4R2, a regulatory subunit of PP4 (show ANXA5 Proteins), mediates the DNA damage-dependent association between RPA2 (show RPA2 Proteins) and the PP4C (show PPP4C Proteins) catalytic subunit.
A three-protein PP4 phosphatase complex in mammalian cells, containing PP4C, PP4R2, and PP4R3beta, specifically dephosphorylates ATR-mediated gamma-H2AX generated during DNA replication.
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair (By similarity). Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage- dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair (By similarity).
serine/threonine-protein phosphatase 4 regulatory subunit 2-A
, protein phosphatase 4, regulatory subunit 2
, serine/threonine-protein phosphatase 4 regulatory subunit 2