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Protein Phosphatase Methylesterase 1 Proteins (PPME1)

PPME1 encodes a protein phosphatase methylesterase localized to the nucleus. Additionally we are shipping Protein Phosphatase Methylesterase 1 Antibodies (58) and Protein Phosphatase Methylesterase 1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PPME1 51400 Q9Y570
PPME1 72590 Q8BVQ5
PPME1 361613 Q4FZT2
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Top Protein Phosphatase Methylesterase 1 Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Schizosaccharomyces pombe His tag   1 mg Log in to see 56 to 66 Days
$2,924.17
Details
Yeast Candida albicans His tag   1 mg Log in to see 56 to 66 Days
$2,982.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,041.50
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$3,059.83
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,059.83
Details
Yeast Candida His tag   1 mg Log in to see 56 to 66 Days
$3,063.50
Details

PPME1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced Protein Phosphatase Methylesterase 1 Proteins

  1. Human PPME1 Protein expressed in Escherichia coli (E. coli) - ABIN667510 : Gagnon, Hengartner, Desnoyers: The genes pme-1 and pme-2 encode two poly(ADP-ribose) polymerases in Caenorhabditis elegans. in The Biochemical journal 2002 (PubMed)
    Show all 2 references for ABIN667510

More Proteins for Protein Phosphatase Methylesterase 1 (PPME1) Interaction Partners

Human Protein Phosphatase Methylesterase 1 (PPME1) interaction partners

  1. LCMT1 (show LCMT1 Proteins)-PME-1 methylation equilibrium is critical for regulating mitotic spindle size and thereby proper cell division

  2. this study suggests that the tightly linked regulatory loop comprised of the SIK2 (show SIK2 Proteins)-PP2A (show PPP2R4 Proteins) and CaMKI (show CAMK1 Proteins) and PME-1 networks may function in fine-tuning cell proliferation and stress response.

  3. PPME1 could be an attractive therapeutic target for a subset of gastric cancer and lung cancer.

  4. Data indicate that PP2A (show PPP2R4 Proteins) holoenzyme biogenesis and activity are controlled by five PP2A (show PPP2R4 Proteins) modulators, consisting of alpha4, PTPA (show PPP2R4 Proteins), LCMT1 (show LCMT1 Proteins), PME-1 and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled.

  5. GSK-3beta can inhibit PP2A (show PPP2R4 Proteins) by increasing the inhibitory L309-demethylation involving upregulation of PME-1 and inhibition of PPMT1 (show LCMT1 Proteins)

  6. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.

  7. We propose that stabilization of this inactive, nuclear PP2A (show PPP2R4 Proteins) pool is a major in vivo function of PME-1.

  8. Observations identify PME-1 expression as one mechanism by which ERK (show EPHB2 Proteins) pathway activity is maintained in cancer cells and suggest an important functional role for PME-1 in the disease progression of human astrocytic gliomas.

Mouse (Murine) Protein Phosphatase Methylesterase 1 (PPME1) interaction partners

  1. protects protein phosphatase 2A from ubiquitin/proteasome degradation

  2. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.

  3. PME-1 plays a critical role in differentiation of neuroblastoma (show ARHGEF16 Proteins) cells.

  4. targeted disruption of the PME-1 gene causes perinatal lethality in mice, a phenotype that correlates with a virtually complete loss of the demethylated form of PP2A (show PPP2R2B Proteins) in the nervous system and peripheral tissues

Protein Phosphatase Methylesterase 1 (PPME1) Protein Profile

Protein Summary

This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with PPME1

  • protein phosphatase methylesterase 1 (ppme1)
  • esterase/lipase/thioesterase family protein (AT4G10050)
  • protein phosphatase methylesterase 1 (LOC100358403)
  • protein phosphatase methylesterase 1 (PPME1)
  • protein phosphatase methylesterase 1 (Ppme1)
  • similar to S. cerevisiae PPE1 (YHR075C) mitochondrial ribosome small subunit protein YMS2, which resembles a phosphatase-methylesterase (PPE1)
  • 1110069N17Rik protein
  • 2700017M01Rik protein
  • DDBDRAFT_0204584 protein
  • DDBDRAFT_0305014 protein
  • DDB_0204584 protein
  • DDB_0305014 protein
  • F28M11.4 protein
  • fk72d03 protein
  • PME-1 protein
  • PME1 protein
  • PME1MGC133824 protein
  • RGD1309683 protein
  • wu:fk72d03 protein
  • zgc:56239 protein

Protein level used designations for PPME1

protein phosphatase methylesterase 1 , phosphatase methylesterase 1 , protein phosphatase methylesterase-1 , PME-1 , likely mitochondrial ribosomal protein (YMS2)

GENE ID SPECIES
335124 Danio rerio
826596 Arabidopsis thaliana
8623168 Dictyostelium discoideum AX4
100195184 Salmo salar
100358403 Oryctolagus cuniculus
446717 Xenopus laevis
419058 Gallus gallus
51400 Homo sapiens
612812 Canis lupus familiaris
535390 Bos taurus
72590 Mus musculus
361613 Rattus norvegicus
100173996 Pongo abelii
3635974 Candida albicans SC5314
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