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PPME1 encodes a protein phosphatase methylesterase localized to the nucleus. Additionally we are shipping Protein Phosphatase Methylesterase 1 Antibodies (58) and Protein Phosphatase Methylesterase 1 Kits (5) and many more products for this protein.
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Human PPME1 Protein expressed in Escherichia coli (E. coli) - ABIN667510
Gagnon, Hengartner, Desnoyers: The genes pme-1 and pme-2 encode two poly(ADP-ribose) polymerases in Caenorhabditis elegans. in The Biochemical journal 2002
Show all 2 references for ABIN667510
LCMT1 (show LCMT1 Proteins)-PME-1 methylation equilibrium is critical for regulating mitotic spindle size and thereby proper cell division
this study suggests that the tightly linked regulatory loop comprised of the SIK2 (show SIK2 Proteins)-PP2A (show PPP2R4 Proteins) and CaMKI (show CAMK1 Proteins) and PME-1 networks may function in fine-tuning cell proliferation and stress response.
PPME1 could be an attractive therapeutic target for a subset of gastric cancer and lung cancer.
Data indicate that PP2A (show PPP2R4 Proteins) holoenzyme biogenesis and activity are controlled by five PP2A (show PPP2R4 Proteins) modulators, consisting of alpha4, PTPA (show PPP2R4 Proteins), LCMT1 (show LCMT1 Proteins), PME-1 and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled.
GSK-3beta can inhibit PP2A (show PPP2R4 Proteins) by increasing the inhibitory L309-demethylation involving upregulation of PME-1 and inhibition of PPMT1 (show LCMT1 Proteins)
Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.
We propose that stabilization of this inactive, nuclear PP2A (show PPP2R4 Proteins) pool is a major in vivo function of PME-1.
Observations identify PME-1 expression as one mechanism by which ERK (show EPHB2 Proteins) pathway activity is maintained in cancer cells and suggest an important functional role for PME-1 in the disease progression of human astrocytic gliomas.
protects protein phosphatase 2A from ubiquitin/proteasome degradation
PME-1 plays a critical role in differentiation of neuroblastoma (show ARHGEF16 Proteins) cells.
targeted disruption of the PME-1 gene causes perinatal lethality in mice, a phenotype that correlates with a virtually complete loss of the demethylated form of PP2A (show PPP2R2B Proteins) in the nervous system and peripheral tissues
This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants.
protein phosphatase methylesterase 1
, phosphatase methylesterase 1
, protein phosphatase methylesterase-1
, likely mitochondrial ribosomal protein (YMS2)