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The protein encoded by QKI is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. Additionally we are shipping QKI Antibodies (94) and many more products for this protein.
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QKI5 could inhibit gastric cancer cell proliferation, migration, and invasion in vitro and in vivo, which might be due to the altered splicing pattern of macroH2A1 (show H2AFY Proteins) pre-mRNA, leading to the accumulation of macroH2A1.1 (show H2AFY Proteins) isoform.
several splicing variants with functional relevance in lung cancer largely regulated by the splicing factor (show SLU7 Proteins) QKI, were identified.
QKI underexpression is associated with glioma.
Our results demonstrate that miR (show MLXIP Proteins)-143-3p acts as a tumor-suppressor by targeting QKI-5 in ESCC, suggesting that miR (show MLXIP Proteins)-143-3p is a potential therapy for the treatment of ESCC.
Methylation of the QKI promoter and concomitant reduced expression of QKI mRNA may be important for CRC (show CALR Proteins) initiation and progression.
quaking is essential in maintaining endothelial barrier function.
QKI-7 recruits PAPD4 (show PAPD4 Proteins) to regulate post-transcriptional polyadenylation of target mRNAs.
QKI has a role in posttranscriptionally guiding macrophage identity and function.
MYB (show MYB Proteins)-QKI rearrangements promote tumorigenesis through three mechanisms: MYB (show MYB Proteins) activation by truncation, enhancer translocation driving aberrant MYB (show MYB Proteins)-QKI expression and hemizygous loss of the tumor suppressor QKI
Data implicate QKI in the pathophysiology of inflammation and leukemoogenesis where miR (show MLXIP Proteins)-155 is involved.
Complementary DNA (cDNA) for bovine quaking gene (Bqk), equine quaking gene (Eqk) and porcine quaking gene (Pqk), which are homologous to mouse quaking gene (qkI), were isolated, and their nucleotide sequences were determined.
miR (show MYLIP Proteins)-499 was negatively correlated to the expression of QKI in testicular tissue.
These data collectively indicate that Qki5 regulates communication between neural stem cells by mediating numerous RNA processing events and suggest new links between splicing regulation and neural stem cell states.
this study explores how levels of two isoforms, nuclear Quaking-5 (Qk5) and cytoplasmic Qk6, are regulated in mouse myoblasts. Qk5 and Qk6 proteins have distinct functions in splicing and translation, respectively, enforced through differential subcellular localization.
QKI is involved in multiple aspects of oligodendroglial development. QKI disruption can impact the cell fate of oligodendrocyte precursor cells, their migration and differentiation, and ultimately myelination in the cerebellum.
Data indicate a central role of microRNA miR-214 in embryonic stem cells (ESCs) - vascular smooth muscle cells (VSMCs) differentiation, and identified quaking (QKI) as a functional modulating target in miR-214 mediated VSMCs differentiation.
QKI was strongly expressed by Muller glial cells in both the developing and adult retina. Neuronal expression was uniformly weak in the adult. QKI-5 was the predominantly expressed isoform in the adult retina.
QKI directly plays a crucial role in the post-transcriptional regulation and expression of Sirt2 (show SIRT2 Proteins) to facilitate oligodendrocyte differentiation.
findings reveal a crucial role for the miR (show MLXIP Proteins)-214-Qki pathway in the regulation of neuronal dendritic development.
we identify QKI as the long-sought regulator of Neurofascin (show NFASC Proteins) alternative splicing
Study establish that the shk mutation, previously localized to chromosome 17, is a quaking (qk) allele consisting of a 105-nucleotide insertion in the qk regulatory region that decreases qk transcription
The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Four transcript variants encoding different isoforms have been found for this gene.
RNA binding protein HQK
, homolog of mouse quaking QKI (KH domain RNA binding protein)
, protein quaking
, quaking homolog, KH domain RNA binding
, RNA binding protein HQK-7B
, quaking protein
, RNA binding/signal transduction protein QkI-2
, QKI, KH domain containing, RNA binding tv1
, QKI-5 protein
, lethal, Chr 17, U Wisconsin 1