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The protein encoded by PTPN14 is a member of the protein tyrosine phosphatase (PTP) family. Additionally we are shipping PTPN14 Antibodies (41) and PTPN14 Proteins (3) and many more products for this protein.
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study determined that high-risk E7 proteins target the proteolysis of the cellular protein tyrosine phosphatase (show ACP1 ELISA Kits) PTPN14 and find that this activity is correlated with the retinoblastoma-independent transforming activity of E7
PTPN14 is classified as a potential tumor suppressor protein (show TP53 ELISA Kits), and is very susceptible to HPV E7-induced proteasome-mediated degradation.
The Hippo signaling pathway was significantly associated with ER-negative breast cancer (pathway level P = 0.02). Gene-based analyses revealed that CDH1 (show CDH1 ELISA Kits) was responsible for the pathway association (P < 0.01),corrected P = 0.02). rs142697907 in PTPN14 was associated with ER-positive breast cancer and rs2456773 in CDK1 (show CDK1 ELISA Kits) with ER-negativity in case-only analysis after gene-level correction
PTPN14, a Pez mammalian homolog, is degraded by overexpressed Su(dx) or Su(dx) homologue WWP1 in mammalian cells.
PTPN14 and PTEN were identified as direct and functional targets of miR (show MLXIP ELISA Kits)-21.
Findings indicate a pathway involving protein-tyrosine phosphatase (show ACP1 ELISA Kits) D2 PTPD2 (PTPN14) and the lipid second messenger phosphatidic acid that promotes ERBB2 (show ERBB2 ELISA Kits) receptor function.
results indicate a potential regulatory role of PTPN14 in the Hippo pathway and demonstrate another layer of regulation in the YAP (show YAP1 ELISA Kits) oncogenic function
Data demonstrate that PTPN14 downregulation can phenocopy YAP (show YAP1 ELISA Kits) activation in mammary epithelial cells and synergize with YAP (show YAP1 ELISA Kits) to induce oncogenic transformation.
Data show that p130 (show RBL2 ELISA Kits) Crk-associated substrate (show BCAR1 ELISA Kits) is a direct substrate of PTPN14 and that PTPN14 specifically regulates p130Cas (show BCAR1 ELISA Kits) phosphorylation at tyrosine residue 128 in colorectal cancer cells.
YAP (show YAP1 ELISA Kits) is a direct substrate of PTPN14. Results indicate a potential regulatory role of PTPN14 on YAP (show YAP1 ELISA Kits) and demonstrate a novel mechanism in YAP (show YAP1 ELISA Kits) regulation.
The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking.
PTPN14 has a role in angiogenesis and/or arteriovenous fate, acting via EphrinB2 (show EFNB2 ELISA Kits) and ACVRL1/activin receptor-like kinase 1 (show ACVRL1 ELISA Kits)
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia.
cytoskeletal-associated protein tyrosine phosphatase
, protein-tyrosine phosphatase pez
, tyrosine-protein phosphatase non-receptor type 14
, protein-tyrosine phosphatase PTP36