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PCDH10 belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. Additionally we are shipping PCDH10 Antibodies (38) and PCDH10 Kits (1) and many more products for this protein.
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These findings suggest that Pcdh10 may influence subcellular actin cytoskeletal organization and axon-axon interactions in the course of familial amyloidotic polyneuropathy
PCDH10 methylation in serum is a potential prognostic biomarker for prostate cancer.
Study found that hypermethylation of CpG probes in the promoter regions of HOXA9 and PCDH10 was associated with mature B-cell neoplasms.
Results suggest that protocadherin 10 (PCDH10)-Dishevelled, EGL-10 and Pleckstrin domain containing 1 (DEPDC1)-caspase signaling may be a novel regulatory axis in endometrial endometrioid carcinoma (EEC) development.
Data show that protocadherin 10 (PCDH10) over-expression could significantly induce cell apoptosis, and restrain proliferation, invasion and migration ability of BXPC-3 pancreatic cancer cells.
Our present findings suggested that the hypermethylated CpG site counts of PCDH10 DNA promoter for evaluating the prognosis of GC was reasonable by using the D-BGS
PCDH10 methylation is a potential biomarker that predicts a poor prognosis after curative resection of pathological stage I non-small-cell lung cancer.
PCDH10 antagonized MM cell proliferation via the downregulation of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)/BCL-9 (show BCL9 Proteins) signaling, whereas PCDH10 repressed the expression of AKT (show AKT1 Proteins) to promote the expression of GSK3beta and then to restrain the activation of beta-catenin (show CTNNB1 Proteins)
These results suggest an important role of p53 in regulating tumor cell migration through activating PCDH10 expression.
Aberrant methylation of PCDH10 predicts worse biochemical recurrence-free survival in patients with prostate cancer after radical prostatectomy.
Studies reveals that male Pcdh10(+/-) mice have synaptic and behavioral deficits, and establish Pcdh10(+/-) mice as a novel genetic model for investigating neural circuitry and behavioral changes relevant to autism spectrum disorder.
Pcdh10, which is regulated by Pou3f1 (show POU3F1 Proteins) and Hoxa5 (show HOXA5 Proteins), is a mediator of like-like clustering of motor neuron cell bodies in the developing phrenic nerve.
results show that OL-pc is essential for both elongation of striatal axons and patterning of the putative guidance cues for thalamocortical projections.
The role of OL-protocadherin-dependent striatal axon growth in neural circuit formation.
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The mRNA encodes a cadherin-related neuronal receptor thought to play a role in the establishment and function of specific cell-cell connections in the brain. This family member contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Alternatively spliced transcripts encode isoforms with unique cytoplasmic domains.
ortholog of OL-pcdh