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PCDH8 belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. Additionally we are shipping Protocadherin 8 Antibodies (29) and many more products for this protein.
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The transcription factor Snail1 (show SNAI1 Proteins) is essential for tissue separation, enabling paraxial protocadherin (PAPC) to promote tissue separation through novel functions.
Because PAPC and C-cadherin do not directly interact nor form a joint complex with Fz7, Wnt-11 triggers formation of two distinct complexes that act in parallel to reduce cell adhesion by hampering clustering of C-cadherin.
Data show that PAPC signaling via RhoA (show RHOA Proteins) and Wnt5a (show WNT5A Proteins)/Ror2 (show ROR2 Proteins) activity are required to keep cells aligned in apical-basal orientation during invagination of the ear placode.
Transcriptional regulation of XPAPC by XWnt-5A (show WNT5A Proteins) requires the receptor tyrosine kinase Ror2 (show ROR2 Proteins).
ShcA (show SHC1 Proteins) is required for Wnt-5a (show WNT5A Proteins)/Ror2 (show ROR2 Proteins) mediated upregulation of xPAPC, which demonstrates the functional relevance of this interaction.
PCDH8 methylation may be associated with tumor progression and poor prognosis in non-muscle invasive bladder cancer.
PCDH8 methylation may be a useful biomarker to predict the progression of clear cell renal cell carcinoma (show MOK Proteins).
Loss of the PCDH8 gene is one of the probable causes of psychomotor delay in RB1 (show RB1 Proteins)-deleted patients.
study demonstrates the epigenetic inactivation of PCDH8 by promoter methylation and its tumor suppressor function in gastric cancer
These results suggest that any contribution of PCDH8 polymorphisms to schizophrenia susceptibility is likely to be weak, although the existence of rare variations of stronger effect cannot be excluded.
Loss of PCDH8 promotes oncogenesis in epithelial human cancers by disrupting cell-cell communication dedicated to tissue organization and repression of mitogenic signaling.
miR (show MLXIP Proteins)-429 suppresses the expression of Pcdh8 mRNA and protein.
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails.
, paraxial protocadherin 8 short isoform
, activity-regulated cadherin-like protein