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Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Additionally we are shipping Prune Homolog (Drosophila) Proteins (7) and Prune Homolog (Drosophila) Kits (5) and many more products for this protein.
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Human Polyclonal PRUNE Primary Antibody for FACS, IHC (p) - ABIN954344
Middelhaufe, Garzia, Ohndorf, Kachholz, Zollo, Steegborn: Domain mapping on the human metastasis regulator protein h-Prune reveals a C-terminal dimerization domain. in The Biochemical journal 2007
Show all 6 references for ABIN954344
h-Prune expression is necessary for cancer cell motility and EMT (show ITK Antibodies) and is associated with liver and lung metastasis in colorectal cancer cells. h-Prune could be a new prognostic marker and molecular target for CRLM.
Data indicate that the D388A and D422A mutant h-Prune proteins interact weakly with Nm23-H1 (show NME1 Antibodies).
GSK-3 (show GSK3b Antibodies) and h-prune cooperatively regulate the disassembly of focal adhesions to promote cell migration and that h-prune is useful as a marker for tumor aggressiveness.
A therapeutic approach to treat prostate cancer by targeting Nm23-H1 (show NME1 Antibodies)/h-Prune interaction
Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1 (By similarity).
prune homolog (Drosophila)
, prune homolog
, protein prune homolog
, Drosophila-related expressed sequence 17