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Tyrosine kinase that may play a role in cell spreading and migration on fibronectin. Additionally we are shipping PEAK1 Antibodies (54) and and many more products for this protein.
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report is the first to provide evidence that PEAK1 mediates signaling cross talk between TGFbeta (show TGFB1 Proteins) receptors and integrin/Src (show SRC Proteins)/MAPK (show MAPK1 Proteins) pathways and that PEAK1 is an important molecular regulator of TGFbeta (show TGFB1 Proteins)-induced tumor progression and metastasis in breast cancer
this regard, we have demonstrated that PEAK1 is necessary for TGFbeta (show TGFB1 Proteins) to induce ZEB1-mediated EMT (show ITK Proteins) in the context of fibronectin (show FN1 Proteins)/ITGB3 (show ITGB3 Proteins) activation.
Suggest that loss of PEAK1/E-cadherin (show CDH1 Proteins) may play an important role in carcinogenesis and development of gastric cancer through activating epithelial to mesenchymal transition.
eIF5A (show EIF5 Proteins) proteins utilize PEAK1 as a downstream effector to drive pancreatic ductal adenocarcinoma (PDAC) pathogenesis.
results define a novel signaling pathway in basal breast cancer involving Lyn (show LYN Proteins) and SgK269 that offers clinical opportunities for therapeutic intervention
phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover
Here, we report that the novel tyrosine kinase (show TXK Proteins) PEAK1 is upregulated in human malignancies, including human PDACs and pancreatic intraepithelial neoplasia (PanIN).
Also known as SgK269. Contains a divergent and possibly inactive eukaryotic protein kinase domain. Has one human paralog, known as SgK223 or pragmin. These two constitute the NKF3 subfamily of protein kinases, found in vertebrates and echinoderms
Tyrosine kinase that may play a role in cell spreading and migration on fibronectin. May directly or indirectly affect phosphorylation levels of cytoskeleton-associated proteins MAPK1/ERK and PXN (By similarity).
pseudopodium enriched atypical kinase
, pseudopodium-enriched atypical kinase 1
, sugen kinase 269
, tyrosine-protein kinase SgK269
, NKF3 kinase family member