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Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) ELISA Kits

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. Additionally we are shipping PDHA1 Proteins (1) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human PDHA1 PDHA1 5160 P08559
Anti-Rat PDHA1 PDHA1 29554  
Anti-Mouse PDHA1 PDHA1 18597 P35486
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More ELISA Kits for PDHA1 Interaction Partners

Human Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) interaction partners

  1. oncoprotein HBXIP (show HBXIP ELISA Kits) enhances glucose metabolism reprogramming through suppressing SCO2 and PDHA1 in breast cancer

  2. MPO (show MPO ELISA Kits) and BPI (show BPI ELISA Kits) in CD4 (show CD4 ELISA Kits)(+)T-lymphocytes, and PDHA1 and MRPL42 (show MRPL42 ELISA Kits) in CD8 (show CD8A ELISA Kits)(+) T-lymphocytes might be used as specific biomarkers of severe asthma progression.

  3. Phosphorylation at distinct serine and tyrosine residues inhibits PDHA1 through distinct mechanisms to impact active site accessibility.

  4. High HK2 (show HK2 ELISA Kits) expression combined with low phosphorylated PDHA1 expression in the invasive front lesions of colorectal tumors is predictive of tumor aggressiveness and survival.

  5. In the presence of PPARbeta (show PPARD ELISA Kits)/delta, Vpr induced a 3.3-fold increase in PPAR (show PPARA ELISA Kits) response element-driven transcriptional activity, a 1.9-fold increase in PDK4 (show PDK4 ELISA Kits) protein expression, and a 1.6-fold increase in the phosphorylated pyruvate dehydrogenase (show PDP ELISA Kits) subunit E1alpha.

  6. In this study the phenotypes of patients with PDH (show PDP ELISA Kits) deficiency have been divided into three groups of mutations.

  7. Expression of the PDHA1 gene was found in all somatic cells, whereas expression of PDHA2 (show PDHa2 ELISA Kits) gene was restricted to germ cells. The switch from X-linked to autosomic gene expression occurred in spermatocytes.

  8. Skin fibroblast culture assay revealed PDH (show PDP ELISA Kits) deficiency, confirmed by mutation analysis of the E1 alpha subunit (show POLG ELISA Kits).

  9. TNFalpha (show TNF ELISA Kits) can inhibit pulmonary artery smooth muscle cells pyruvate dehydrogenase (show PDP ELISA Kits) activity and induce a pulmonary arterial hypertension phenotype.

  10. We provide an efficient stepwise strategy for mutation screening in pyruvate dehydrogenase (show PDP ELISA Kits) complex genes and expand the growing list of PDHA1 mutations analyzed at the structural level

Zebrafish Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) interaction partners

  1. The study provired that pyruvate dehydrogenase (show PDK2 ELISA Kits)-deficient mutant caused the retinal drficits in zebrafish.

Mouse (Murine) Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) interaction partners

  1. The present findings suggest that IL-6 (show IL6 ELISA Kits) contributes to regulating the PDHa activity and hence carbohydrate oxidation, but the metabolic state of the muscle seems to determine the outcome of this regulation

  2. Liver-specific pyruvate dehydrogenase (show PDP ELISA Kits) complex deficiency upregulates lipogenesis in adipose tissue and improves peripheral insulin (show INS ELISA Kits) sensitivity.

  3. PGC-1alpha (show PPARGC1A ELISA Kits) regulates PDH (show PDP ELISA Kits)-E1alpha protein content in parallel with mitochondrial oxidative proteins, but does not seem to influence PDH (show PDP ELISA Kits) regulation in mouse skeletal muscle in response to fasting and in recovery from exercise.

  4. Embryos carrying predominantly the Pdha1(deletion in exon 8, Deltaex8) allele were found to be globally delayed in development by 9.5 days postcoitus, with resorption occurring over the following several days.

PDHA1 Antigen Profile

Antigen Summary

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PDHA1

  • pyruvate dehydrogenase (lipoamide) alpha 1 (pdha1) antibody
  • pyruvate dehydrogenase (lipoamide) alpha 1 (PDHA1) antibody
  • PdhA1 (pdhA1) antibody
  • pyruvate dehydrogenase E1 component subunit alpha (pdhA1) antibody
  • pyruvate dehydrogenase alpha subunit protein (pdhA1) antibody
  • pyruvate dehydrogenase (acetyl-transferring) protein, alpha subunit (pdhA1) antibody
  • precursor of dehydrogenase pyruvate dehydrogenase E1 component alpha subunit (PDHA1) antibody
  • pyruvate dehydrogenase (PDHA1) antibody
  • pyruvate dehydrogenase (lipoamide) alpha 1 (Pdha1) antibody
  • pyruvate dehydrogenase (lipoamide) alpha 1b (pdha1b) antibody
  • pyruvate dehydrogenase E1 alpha 1 (Pdha1) antibody
  • PDHA antibody
  • Pdha-1 antibody
  • Pdha1 antibody
  • PDHCE1A antibody
  • PHE1A antibody
  • wu:fp73b04 antibody
  • zgc:92705 antibody

Protein level used designations for PDHA1

pyruvate dehydrogenase E1 alpha 1 , pyruvate dehydrogenase (lipoamide) alpha 1 , PdhA1 , pyruvate dehydrogenase alpha subunit , pyruvate dehydrogenase E1 component subunit alpha , pyruvate dehydrogenase alpha subunit protein , pyruvate dehydrogenase (acetyl-transferring) protein, alpha subunit , precursor of dehydrogenase pyruvate dehydrogenase E1 component alpha subunit , pyruvate dehydrogenase , pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial , PDHE1-A type I , pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial-like , pyruvate dehydrogenase complex, E1-alpha polypeptide 1 , Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial , pyruvate dehydrogenase E1 component alpha subunit , pyruvate dehydrogenase E1alpha subunit , pyruvate dehydrogenase alpha 1 , fp73b04

GENE ID SPECIES
549826 Xenopus (Silurana) tropicalis
719277 Macaca mulatta
1448416 Halobacterium sp. NRC-1
3129238 Haloarcula marismortui ATCC 43049
3893971 Rhizobium etli CFN 42
6400117 Rhizobium etli CIAT 652
7195506 Phaeodactylum tricornutum CCAP 1055/1
7369176 Agrobacterium radiobacter K84
7450426 Thalassiosira pseudonana CCMP1335
100174745 Pongo abelii
100357349 Oryctolagus cuniculus
100400144 Callithrix jacchus
100471829 Ailuropoda melanoleuca
100587584 Nomascus leucogenys
418610 Gallus gallus
5160 Homo sapiens
480858 Canis lupus familiaris
100294678 Sus scrofa
407109 Bos taurus
29554 Rattus norvegicus
465525 Pan troglodytes
436672 Danio rerio
18597 Mus musculus
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