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anti-Pyruvate Dehydrogenase Complex, Component X (PDHX) Antibodies

The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. Additionally we are shipping Pyruvate Dehydrogenase Complex, Component X Proteins (5) and Pyruvate Dehydrogenase Complex, Component X Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PDHX 8050 O00330
PDHX 27402 Q8BKZ9
PDHX 311254  
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Top anti-Pyruvate Dehydrogenase Complex, Component X Antibodies at antibodies-online.com

Showing 10 out of 48 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Western blot analysis of anti-PDX1 Antibody (T11) (ABIN388774) in NCI-H460 cell line lysates (35 µg/lane).PDX1-T11(arrow) was detected using the purified polyclonal antibody. Western blot analysis of PDX1 (arrow) using PDX1 Antibody (T11) (ABIN388774). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the PDX1 gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN185236 (1µg/ml) staining of Human Pancreas lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. ABIN185389 staining of paraffin embedded Human Pancreas. A) Microwaved antigen retrieval with citrate buffer pH 6 (3µg/ml), HRP-staining. B) Microwaved antigen retrieval with Tris/EDTA buffer pH9 (1µg/ml) , HRP-staining. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated WB The anti-PDX1 Pab (ABIN388773) is used in Western blot to detect PDX1 in mouse heart tissue lysate. Western blot analysis of PDX1 (arrow) using rabbit polyclonal PDX1 Antibody (C-term) (ABIN388773). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the PDX1 gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: A431 , B: H1299 C: Hela 10% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Goat Un-conjugated IHC, ELISA, WB 100 μg Log in to see 8 to 10 Days
$595.83
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$527.15
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Mouse Un-conjugated ELISA, WB PDHX polyclonal antibody (A01), Lot # 051213JCO1 Western Blot analysis of PDHX expression in HepG2 . Western Blot detection against Immunogen (38.1 KDa) . 50 μL Log in to see 9 Days
$298.57
Details

PDHX Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Pyruvate Dehydrogenase Complex, Component X Antibodies

  1. Human Polyclonal PDHX Primary Antibody for EIA, WB - ABIN357415 : Ling, McEachern, Seyda, MacKay, Scherer, Bratinova, Beatty, Giovannucci-Uzielli, Robinson: Detection of a homozygous four base pair deletion in the protein X gene in a case of pyruvate dehydrogenase complex deficiency. in Human molecular genetics 1998 (PubMed)
    Show all 4 references for ABIN357415

  2. Human Polyclonal PDHX Primary Antibody for IF, IHC (p) - ABIN388774 : Aral, Benelli, Ait-Ghezala, Amessou, Fouque, Maunoury, Créau, Kamoun, Marsac: Mutations in PDX1, the human lipoyl-containing component X of the pyruvate dehydrogenase-complex gene on chromosome 11p1, in congenital lactic acidosis. in American journal of human genetics 1998 (PubMed)
    Show all 3 references for ABIN388774

  3. Human Polyclonal PDHX Primary Antibody for EIA, IHC (p) - ABIN357414 : Murray, Gilkerson, Capaldi: Quantitative proteomics: the copy number of pyruvate dehydrogenase is more than 10(2)-fold lower than that of complex III in human mitochondria. in FEBS letters 2002 (PubMed)
    Show all 3 references for ABIN357414

  4. Human Polyclonal PDHX Primary Antibody for WB - ABIN388773 : Harris, Bowker-Kinley, Wu, Jeng, Popov: Dihydrolipoamide dehydrogenase-binding protein of the human pyruvate dehydrogenase complex. DNA-derived amino acid sequence, expression, and reconstitution of the pyruvate dehydrogenase complex. in The Journal of biological chemistry 1997 (PubMed)
    Show all 2 references for ABIN388773

  5. Human Polyclonal PDHX Primary Antibody for IHC, ELISA - ABIN185389 : Roche, Baker, Yan, Hiromasa, Gong, Peng, Dong, Turkan, Kasten: Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms. in Progress in nucleic acid research and molecular biology 2001 (PubMed)

More Antibodies against Pyruvate Dehydrogenase Complex, Component X Interaction Partners

Human Pyruvate Dehydrogenase Complex, Component X (PDHX) interaction partners

  1. We propose testing for the R446* mutation in PDHX as a rapid first screening in Roma infants with metabolic acidosis.

  2. MiR (show MLXIP Antibodies)-26a regulates glucose metabolism of colorectal cancer cells by direct targeting PDHX.

  3. New mutation in PDHX gene found in two unrelated patients with Pyruvate dehydrogenase (show PDP Antibodies) deficiency.

  4. genetic association with systemic lupus erythematosus to a haplotype between PDHX and CD44 (show CD44 Antibodies) was established.

  5. determination that PDH (show PDP Antibodies) and complex III exist at a steady-state ratio of 1:100, 1:128 and 1:202 in HeLa cell extracts, fibroblast mitochondria and heart tissue mitochondria, respectively

  6. model of the pyruvate dehydrogenase (show PDP Antibodies) complex formed by E2 and E2 plus the E3-binding protein and binding of the E1 and E3 components

  7. specificity of pairing for human E3BP with E3 from its subcomplex structure to be most likely due to conformational rigidity of the binding fragment of the E3-binding domain of E3BP and its exquisite amino acid match with the E3 target interface

  8. A cluster of disease-causing E3 mutations located near the center of the E3BD/E3 interface prevents the efficient recruitment of these E3 variants by E3BP into the PDC (show PNKD Antibodies), leading to the dysfunction of the PDC (show PNKD Antibodies) catalytic machine.

  9. These data provide an additional case of E3BP deficiency with a unique and previously unreported deletion in the PDHX gene.

  10. Despite the presence of antibodies reactive with PDC (show PNKD Antibodies)-E3BP in the majority of primary biliary cirrhosis (PBC (show DLAT Antibodies)) patients this self-protein is not a dominant T-cell autoantigen in PBC (show DLAT Antibodies).

Mouse (Murine) Pyruvate Dehydrogenase Complex, Component X (PDHX) interaction partners

  1. T1a/podoplanin (show PDPN Antibodies) is first expressed in prox 1 (show PROX1 Antibodies)-positive lymphatic progenitor cells, with predominant localization in the luminal plasma membrane of lymphatic endothelial cells during later development.

  2. In islet cells both fat and glucose regulate PDK (show PDK2 Antibodies) gene and protein expression and indicate that hyperglycemia and hyperlipidemia contribute to the decline in diabetic islet PDH (show PDP Antibodies) activity by increasing mRNA and protein expression of PDK (show PDK2 Antibodies).

Cow (Bovine) Pyruvate Dehydrogenase Complex, Component X (PDHX) interaction partners

  1. This study showed that the recombinant and bovine E2/E3BP cores bind E3s with a 2:1 stoichiometry, and propose that mammalian PDC (show PDC Antibodies) comprises a heterogeneous population of assemblies incorporating a network of E3 cross-bridges above the core surface.

Pyruvate Dehydrogenase Complex, Component X (PDHX) Antigen Profile

Protein Summary

The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit\; also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with PDHX

  • pyruvate dehydrogenase complex, component X (pdhx) antibody
  • pyruvate dehydrogenase complex, component X (PDHX) antibody
  • E3-binding protein (pdhX) antibody
  • pyruvate dehydrogenase complex, component X (LOC100220979) antibody
  • pyruvate dehydrogenase complex, component X (LOC100349815) antibody
  • pyruvate dehydrogenase complex, component X (Pdhx) antibody
  • pyruvate dehydrogenase protein X component-like (LOC517402) antibody
  • Ac1164 antibody
  • AI481367 antibody
  • DDBDRAFT_0168431 antibody
  • DDBDRAFT_0230192 antibody
  • DDB_0168431 antibody
  • DDB_0230192 antibody
  • DLDBP antibody
  • E3bp antibody
  • MGC86218 antibody
  • OPDX antibody
  • PDHX antibody
  • Pdx1 antibody
  • proX antibody
  • zgc:66110 antibody
  • zgc:85977 antibody

Protein level used designations for PDHX

pyruvate dehydrogenase complex, component X , pyruvate dehydrogenase protein X component, mitochondrial-like , dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex , lipoyl-containing pyruvate dehydrogenase complex component X , pyruvate dehydrogenase complex, E3-binding protein subunit , pyruvate dehydrogenase complex, lipoyl-containing component X , pyruvate dehydrogenase protein X component, mitochondrial , dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex (E3-binding protein) (proX) , E3-binding protein , E3BP , proX , pyruvate dehydrogenase protein X component

GENE ID SPECIES
393532 Danio rerio
423154 Gallus gallus
447247 Xenopus laevis
451120 Pan troglodytes
8618072 Dictyostelium discoideum AX4
100059260 Equus caballus
100220979 Taeniopygia guttata
100349815 Oryctolagus cuniculus
100379696 Xenopus (Silurana) tropicalis
100455315 Pongo abelii
100475970 Ailuropoda melanoleuca
100544023 Meleagris gallopavo
100586539 Nomascus leucogenys
8050 Homo sapiens
27402 Mus musculus
311254 Rattus norvegicus
475942 Canis lupus familiaris
517402 Bos taurus
Selected quality suppliers for anti-Pyruvate Dehydrogenase Complex, Component X (PDHX) Antibodies
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