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The protein encoded by PKLR is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Additionally we are shipping Pyruvate Kinase, Liver and RBC Kits (31) and Pyruvate Kinase, Liver and RBC Proteins (22) and many more products for this protein.
Showing 10 out of 144 products:
Human Polyclonal PKLR Primary Antibody for EIA, IHC (p) - ABIN359110
Wang, Chu, Das, Ren, Hasstedt, Elbein: Liver pyruvate kinase polymorphisms are associated with type 2 diabetes in northern European Caucasians. in Diabetes 2002
Show all 4 references for ABIN359110
Human Polyclonal PKLR Primary Antibody for EIA, IHC (p) - ABIN359109
Valentini, Chiarelli, Fortin, Dolzan, Galizzi, Abraham, Wang, Bianchi, Zanella, Mattevi: Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia. in The Journal of biological chemistry 2002
Show all 4 references for ABIN359109
Human Monoclonal PKLR Primary Antibody for EIA, WB - ABIN781545
Meza, Alonso-Ferrero, Navarro, Quintana-Bustamante, Valeri, Garcia-Gomez, Bueren, Bautista, Segovia: Rescue of pyruvate kinase deficiency in mice by gene therapy using the human isoenzyme. in Molecular therapy : the journal of the American Society of Gene Therapy 2009
Show all 2 references for ABIN781545
Caenorhabditis elegans (C. elegans) Polyclonal PKLR Primary Antibody for IHC, WB - ABIN2776945
Pendergrass, Williams, Blair, Fenton: Mining for allosteric information: natural mutations and positional sequence conservation in pyruvate kinase. in IUBMB life 2006
AMPD3 deficiency increases the level of ATP in erythrocytes, but does not improve anemia due to pyruvate kinase deficiency and leads to erythrocyte dysfunction.
Pyruvate kinase deficiency in mice protects against malaria
Data show that pyruvate kinase (PK) activity was decreased in the GATA1 (show GATA1 Antibodies) hemizygous state and PKLR c.1284delA variant.
An update of PKLR gene mutation database has been presented. (Review)
Two Novel Missense Mutations and a 5bp Deletion in the Erythroid-Specific Promoter of the PKLR Gene in Two Unrelated Patients With Pyruvate Kinase Deficient Transfusion-Dependent Chronic Nonspherocytic Hemolytic Anemia.
PKLR promotes colorectal cancer liver colonization through induction of glutathione synthesis.
Pyruvate kinase variants modulate malaria phenotypes in a Thai population.
661G>A and 1528C>T mutations of PKLR gene are associated with pyruvate kinase deficiency.
Case Report: unknown mutation in the pyruvate kinase gene (PKLR) identified from a neonate with severe jaundice.
This study determined which interactions in the fructose 1,6-bisphosphate binding site of human liver pyruvate kinase contribute to allostery.
Partial pyruvate kinase deficiency aggravates the phenotypic expression of band 3 (show SLC4A1 Antibodies) deficiency in a family with hereditary spherocytosis.
Hemolytic anemia associated with a novel heterozygous mutation 1183A in the pyruvate kinase gene has been found in two unrelated Jordanian patients.
The existence of mitochondrial Pyruvate kinase was confirmed by immunological analysis in pig liver mitochondria.
The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene.
pyruvate kinase isozymes R/L
, pyruvate kinase, liver and RBC
, Pyruvate kinase isozyme R
, pyruvate kinase isozymes R/L-like
, pyruvate kinase PKLR
, pyruvate kinase isozymes L/R
, R-type/L-type pyruvate kinase
, pyruvate kinase 1
, pyruvate kinase isozyme R/L
, pyruvate kinase type L
, pyruvate kinase, liver and blood cell
, red cell/liver pyruvate kinase
, Pyruvate kinase isozymes R/L
, pyruvate kinase, liver and red blood cell