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anti-Pyruvate Kinase, Liver and RBC (PKLR) Antibodies

The protein encoded by PKLR is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Additionally we are shipping Pyruvate Kinase, Liver and RBC Kits (38) and Pyruvate Kinase, Liver and RBC Proteins (21) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PKLR 18770  
PKLR 5313 P30613
PKLR 24651 P12928
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Top anti-Pyruvate Kinase, Liver and RBC Antibodies at antibodies-online.com

Showing 10 out of 142 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. The anti-PKLR Pab is used in Western blot to detect PKLR in NIH/3T3 cell lysate. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. The anti-PKLR Pab is used in Western blot to detect PKLR in mouse liver tissue lysate. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Caenorhabditis elegans Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Mouse Un-conjugated EIA, WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-PKLR Picoband antibody, Western blotting All lanes: Anti PKLR  at 0.5ug/ml Lane 1: Rat Liver Tissue Lysate at 50ug Lane 2: Mouse Liver Tissue Lysate at 50ug Predicted bind size: 62KD Observed bind size: 62KD Anti-PKLR Picoband antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-PKLR Pab (ABIN391051) is used in Western blot to detect PKLR in mouse liver tissue lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-PKLR Pab (ABIN391050) is used in Western blot to detect PKLR in NIH/3T3 cell lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC, WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Dog Rabbit Un-conjugated WB Western blot analysis of PKLR expression in Hela (A), Raw264.7 (B), PC12 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Mouse Un-conjugated FACS, IF, WB 100 μL Log in to see 8 to 10 Days
$493.17
Details

PKLR Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,


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Human , ,
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Rat (Rattus)


Top referenced anti-Pyruvate Kinase, Liver and RBC Antibodies

  1. Human Polyclonal PKLR Primary Antibody for EIA, IHC (p) - ABIN359110 : Wang, Chu, Das, Ren, Hasstedt, Elbein: Liver pyruvate kinase polymorphisms are associated with type 2 diabetes in northern European Caucasians. in Diabetes 2002 (PubMed)
    Show all 4 references for ABIN359110

  2. Human Polyclonal PKLR Primary Antibody for EIA, IHC (p) - ABIN359109 : Valentini, Chiarelli, Fortin, Dolzan, Galizzi, Abraham, Wang, Bianchi, Zanella, Mattevi: Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia. in The Journal of biological chemistry 2002 (PubMed)
    Show all 4 references for ABIN359109

  3. Human Monoclonal PKLR Primary Antibody for EIA, WB - ABIN781545 : Meza, Alonso-Ferrero, Navarro, Quintana-Bustamante, Valeri, Garcia-Gomez, Bueren, Bautista, Segovia: Rescue of pyruvate kinase deficiency in mice by gene therapy using the human isoenzyme. in Molecular therapy : the journal of the American Society of Gene Therapy 2009 (PubMed)
    Show all 2 references for ABIN781545

  4. Caenorhabditis elegans (C. elegans) Polyclonal PKLR Primary Antibody for IHC, WB - ABIN2776945 : Pendergrass, Williams, Blair, Fenton: Mining for allosteric information: natural mutations and positional sequence conservation in pyruvate kinase. in IUBMB life 2006 (PubMed)

More Antibodies against Pyruvate Kinase, Liver and RBC Interaction Partners

Mouse (Murine) Pyruvate Kinase, Liver and RBC (PKLR) interaction partners

  1. AMPD3 deficiency increases the level of ATP in erythrocytes, but does not improve anemia due to pyruvate kinase deficiency and leads to erythrocyte dysfunction.

  2. Pyruvate kinase deficiency in mice protects against malaria

Human Pyruvate Kinase, Liver and RBC (PKLR) interaction partners

  1. An update of PKLR gene mutation database has been presented. (Review)

  2. Two Novel Missense Mutations and a 5bp Deletion in the Erythroid-Specific Promoter of the PKLR Gene in Two Unrelated Patients With Pyruvate Kinase Deficient Transfusion-Dependent Chronic Nonspherocytic Hemolytic Anemia.

  3. PKLR promotes colorectal cancer liver colonization through induction of glutathione synthesis.

  4. Pyruvate kinase variants modulate malaria phenotypes in a Thai population.

  5. 661G>A and 1528C>T mutations of PKLR gene are associated with pyruvate kinase deficiency.

  6. Case Report: unknown mutation in the pyruvate kinase gene (PKLR) identified from a neonate with severe jaundice.

  7. This study determined which interactions in the fructose 1,6-bisphosphate binding site of human liver pyruvate kinase contribute to allostery.

  8. Partial pyruvate kinase deficiency aggravates the phenotypic expression of band 3 (show SLC4A1 Antibodies) deficiency in a family with hereditary spherocytosis.

  9. Hemolytic anemia associated with a novel heterozygous mutation 1183A in the pyruvate kinase gene has been found in two unrelated Jordanian patients.

  10. 11 patients from 10 unrelated pyruvate kinse deficiency families had 9 different disease-causing PKLR mutations, including 2 new ones: the point mutation c.878A>T (p.Asp293Val) and the frameshift deletion c.1553delG (p.(Arg518Leufs*12).

Pig (Porcine) Pyruvate Kinase, Liver and RBC (PKLR) interaction partners

  1. The existence of mitochondrial Pyruvate kinase was confirmed by immunological analysis in pig liver mitochondria.

Pyruvate Kinase, Liver and RBC (PKLR) Antigen Profile

Protein Summary

The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PKLR

  • pyruvate kinase, liver and RBC (pklr) antibody
  • pyruvate kinase, liver and RBC (PKLR) antibody
  • pyruvate kinase, muscle (pkm) antibody
  • pyruvate kinase liver and red blood cell (Pklr) antibody
  • pyruvate kinase, liver and RBC (Pklr) antibody
  • cthbp antibody
  • oip3 antibody
  • Pk-1 antibody
  • PK1 antibody
  • pk3 antibody
  • PKL antibody
  • Pklg antibody
  • pklr antibody
  • pkm2 antibody
  • PKR antibody
  • PKRL antibody
  • R-PK antibody
  • RPK antibody
  • tcb antibody
  • thbp1 antibody
  • wu:fd15e01 antibody
  • wu:fi37e08 antibody

Protein level used designations for PKLR

pyruvate kinase isozymes R/L , pyruvate kinase, liver and RBC , Pyruvate kinase isozyme R , pyruvate kinase isozymes R/L-like , L-PK , pyruvate kinase PKLR , pyruvate kinase isozymes L/R , R-type/L-type pyruvate kinase , pyruvate kinase 1 , pyruvate kinase isozyme R/L , pyruvate kinase type L , pyruvate kinase, liver and blood cell , red cell/liver pyruvate kinase , Pyruvate kinase isozymes R/L , pyruvate kinase, liver and red blood cell

GENE ID SPECIES
114551 Danio rerio
406183 Canis lupus familiaris
469513 Pan troglodytes
549224 Xenopus (Silurana) tropicalis
719152 Macaca mulatta
100380137 Xenopus (Silurana) tropicalis
100391903 Callithrix jacchus
18770 Mus musculus
398967 Xenopus laevis
5313 Homo sapiens
490425 Canis lupus familiaris
539579 Bos taurus
24651 Rattus norvegicus
100355056 Oryctolagus cuniculus
100533203 Sus scrofa
100716756 Cavia porcellus
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