PKLR antibody

Catalog No. ABIN781545

The Mouse Monoclonal anti-PKLR antibody (Clone AT1E3) (ABIN781545) specifically detects PKLR in WB and EIA. The antibody is reactive with Human samples.

Quick Overview for PKLR antibody (ABIN781545)

Target: PKLR (Pyruvate Kinase, Liver and RBC (PKLR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PKLR antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: AT1E3

Product Details anti-PKLR Antibody

Specificity: The antibody recognizes human PKLR. Other species not tested.

Purification: Protein-G affinity chromatography

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, containing 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Target Details for PKLR

Target: PKLR (Pyruvate Kinase, Liver and RBC (PKLR))

Alternative Name: PKLR

Background: PKLR is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. The PKLR gene encodes the L- and R-type isoenzymes through alternative splicing events under the control of different promoters. The L-type isoform also exists as a tetramer and is upregulated by glucose with implications in maturity-onset diabetes of the young.Synonyms: PK1, PKL, Pyruvate kinase 1, Pyruvate kinase R/L, Pyruvate kinase isozymes R/L, R-type/L-type pyruvate kinase, Red cell/liver pyruvate kinase

Gene ID: 5313

Pathways: Ribonucleoside Biosynthetic Process