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RAB Guanine Nucleotide Exchange Factor (GEF) 1 Proteins (RABGEF1)

RABGEF1 forms a complex with rabaptin-5 (RABPT5\; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A\; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010].. Additionally we are shipping RABGEF1 Antibodies (27) and RABGEF1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RABGEF1 27342 Q9UJ41
RABGEF1 56715 Q9JM13
Rat RABGEF1 RABGEF1 360797  
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Top RABGEF1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,393.50
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

RABGEF1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for RAB Guanine Nucleotide Exchange Factor (GEF) 1 (RABGEF1) Interaction Partners

Human RAB Guanine Nucleotide Exchange Factor (GEF) 1 (RABGEF1) interaction partners

  1. The results contradict the model of feedback activation of Rab5 (show RAB5A Proteins) and instead indicate that Rbpt5 is recruited by both Rabex5 recognizing ubiquitylated cargo and by Rab4 (show RAB4A Proteins) to activate Rab5 (show RAB5A Proteins) in a feed-forward manner.

  2. RABEX-5 is a potential useful indicator and predicts a poor long-term prognosis for small cell lung cancer(SCLC), which should be considered in defining the prognosis with other well-known prognosticators in C-SCLC patients

  3. Expression of RABEX-5 is significantly higher in gastric cancer tissues and is associated with tumor size and lymph node metastasis.

  4. analysis of Rabex-5 GEF activation by Rabaptin-5

  5. This implies that Rap (show LRPAP1 Proteins) regulates endothelial barrier function by dual control of cytoskeletal tension. The molecular details of the signaling pathways are becoming to be elucidated

  6. RABEX-5 mRNA expression is a strong predictor of poor prognosis in prostate cancer patients treated by radical prostatectomy.

  7. Interaction of Rabex-5 with Rab5 (show RAB5A Proteins) depends on interaction of the MIU domain with the ubiquitinated L1 to drive its internalization.

  8. KCa2.3 (show KCNN3 Proteins) is localized to a caveolin-rich domain within the plasma membrane and is endocytosed in a dynamin (show DNM1 Proteins)- and Rab5 (show RAB5A Proteins)-dependent manner.

  9. a novel mechanistic insight into how Rabex-5 regulates internalization and postendocytic trafficking of ubiquitinated L1 destined for lysosomal degradation.

  10. RABEX-5 and RAB5 (show RAB5A Proteins) may be involved in the development of breast cancer metastasis.

Mouse (Murine) RAB Guanine Nucleotide Exchange Factor (GEF) 1 (RABGEF1) interaction partners

  1. Knockdown of RABEX-5 also inhibited wound healing, migration and the invasive abilities of gastric cancer cells.

  2. Hyperinsulinemia induced insulin (show INS Proteins) resistance in 3T3-L1 adipocytes by retaining GLUT4 (show SLC2A4 Proteins) in a Rab5 (show RAB5A Proteins)-activity-dependent compartment.

  3. Kruppel-like factor 5 (show KLF5 Proteins) is indispensable for adhesion, homing, lodging and retention of haematopoietic stem cells and progenitors in the bone marrow through Rab5 (show RAB5A Proteins)-dependent post-translational regulation of beta1/beta2 integrins

  4. Rab5 (show RAB5A Proteins) is required for phagocytosis of heat-inactivated Pseudomonas aeruginosa by macrophages.

  5. Rabex-5 regulates neurite morphogenesis of hippocampal neurons by activating at least two downstream targets, Rab5 (show RAB5A Proteins), which is localized in both axons and dendrites, and Rab17 (show RAB17 Proteins), which is localized in dendrites alone

  6. a novel mechanistic insight into how Rabex-5 regulates internalization and postendocytic trafficking of ubiquitinated L1 destined for lysosomal degradation.

  7. Data show that RabGEF1 can negatively regulate thymic stromal lymphopoietin (TSLP (show TSLP Proteins)) production in vivo and that excessive production of TSLP (show TSLP Proteins) contributes to many of the phenotypic abnormalities in Rabgef1-/- mice.

  8. Data reveal the affinity of Rabex-5/Rabaptin-5/Rab5 (show RAB5A Proteins)-GTP (show AK3 Proteins) interaction in the cell, which is quantitatively related to the Rabex-5 concentration for the onset of the indirect positive feedback pathway.

  9. Data report the identification of Rab22 (show RAD51AP1 Proteins) as a binding site on early endosomes for direct recruitment of Rabex-5 and activation of Rab5 (show RAB5A Proteins), establishing a Rab22 (show RAD51AP1 Proteins)-Rab5 (show RAB5A Proteins) signaling relay to promote early endosome fusion.

  10. RabGEF1 is a negative regulator of Fc epsilon RI-dependent mast cell activation, and a lack of RabGEF1 results in the development of skin inflammation in vivo.

Cow (Bovine) RAB Guanine Nucleotide Exchange Factor (GEF) 1 (RABGEF1) interaction partners

  1. these data suggest differential physiological roles of the two ubiquitin binding domains in Rabex-5.

  2. Receptor recycling is mediated by AP-1 (show JUN Proteins)/clathrin-coated vesicles and regulated by rab4 (show RAB4A Proteins) and rabaptin-5/rabex-5.

  3. Rabex-5 is a ubiquitin ligase that binds ubiquitin and undergoes ubiquitination; the N-terminal region of Rabex-5 (residues 1-76) is important for ubiquitin binding and ubiquitination.

  4. The structure of the N-terminal portion of Rabex-5 bound to ubiquitin at 2.5-A resolution shows that Rabex-5-ubiquitin interactions occur at two sites

  5. Rabex-5 can target to early endosomes via the EET domain and activate Rab5 in a Rabaptin-5-independent manner in vivo.

  6. Data show that ubiquitin binding is essential for the recruitment of Rabex-5 from the cytosol to endosomes, independently of its guanine nucleotide exchange factor (show ARHGEF12 Proteins) activity and of Rab5 (show RAB5A Proteins).

RABGEF1 Protein Profile

Protein Summary

RABGEF1 forms a complex with rabaptin-5 (RABPT5\; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A\; MIM 179512) (Horiuchi et al., 1997

Gene names and symbols associated with RABGEF1

  • RAB guanine nucleotide exchange factor (GEF) 1 (RABGEF1)
  • RAB guanine nucleotide exchange factor (GEF) 1 (Rabgef1)
  • Rab5ef protein
  • rabex-5 protein
  • Rabex5 protein
  • Rin2 protein

Protein level used designations for RABGEF1

RAP1 , rab5 GDP/GTP exchange factor , rabaptin-5-associated exchange factor for Rab5 , Rab5 exchange factor , Ras negative regulator Rabex-5 , Ras negative regulator Rabex-5/Rin2 , rabex-5 , Rab5 guanine nucleotide exchange factor Rabex-5

GENE ID SPECIES
27342 Homo sapiens
56715 Mus musculus
360797 Rattus norvegicus
282335 Bos taurus
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