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Proteins of the large Rab GTPase family (see RAB1A\; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. Additionally we are shipping RAB11 Family Interacting Protein 4 (Class II) Antibodies (11) and many more products for this protein.
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Results show the expression of Rab11-FIP4 upregulated in hepatocellular carcinoma (HCC (show FAM126A Proteins)) and correlated with poor prognosis. Rab11-FIP4 dramatically contributed to HCC (show FAM126A Proteins) metastasis via phosphorylation of PRAS40 (show AKT1S1 Proteins).
Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells.
FIP3 (show IKBKG Proteins) and FIP4 serve to couple Rab11 (show RAB11A Proteins)-positive vesicle traffic from recycling endosomes to the cleavage furrow/midbody where they are tethered prior to fusion events via interactions with Arf6 (show ARF6 Proteins) and the Exocyst.
identification of Rab11-family interacting protein 4 (Rab11-FIP4) as a gene strongly expressed in the developing mouse retina.
Proteins of the large Rab GTPase family (see RAB1A\; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP4 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001
, rab11 family-interacting protein 4