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RAB proteins, such as RAB25, are members of the RAS superfamily of small GTPases that are involved in membrane trafficking. Additionally we are shipping RAB25 Proteins (8) and many more products for this protein.
Showing 10 out of 69 products:
Human Polyclonal RAB25 Primary Antibody for EIA, WB - ABIN954409
Cheng, Volk, Janaki, Vyakaranam, Ran, Rao: Tumor suppressor function of Rab25 in triple-negative breast cancer. in International journal of cancer. Journal international du cancer 2010
Show all 3 references for ABIN954409
Human Monoclonal RAB25 Primary Antibody for EIA, FACS - ABIN1108809
Goldenring, Shen, Vaughan, Modlin: Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung. in The Journal of biological chemistry 1993
Show all 2 references for ABIN1108809
Human Monoclonal RAB25 Primary Antibody for ELISA, IHC - ABIN2869179
Wang, Kumar, Navarre, Casanova, Goldenring: Regulation of vesicle trafficking in madin-darby canine kidney cells by Rab11a and Rab25. in The Journal of biological chemistry 2000
Show all 2 references for ABIN2869179
Human Monoclonal RAB25 Primary Antibody for IHC (fro), IHC (p) - ABIN449921
Davidson, Holth, Hellesylt, Tan, Huang, Tropé, Nesland, Thiery: The clinical role of epithelial-mesenchymal transition and stem cell markers in advanced-stage ovarian serous carcinoma effusions. in Human pathology 2014
Rab25 was upregulated in hepatocellular carcinoma tissues and cells compared with normal liver tissues and cell lines. Rab25 overexpression correlated with advanced tumor stage and nodal metastasis.Rab25 depletion blocked cell growth rate, inhibited colony formation, downregulated AKT (show AKT1 Antibodies) phosphorylation, inhibited the Wnt (show WNT2 Antibodies) signaling pathway and its target genes, and negatively regulated the invading ability of HCC (show FAM126A Antibodies) cells.
Data show that both rab (show HRB Antibodies) G-Protein RAB25 and RNA-binding protein (show PTBP1 Antibodies) ESRP1 (show ESRP1 Antibodies) were suppressed by transcription factor ZEB1 (show ZEB1 Antibodies), which was in turn regulated via epigenetic mechanisms.
Rab25 expression is a potential prognostic index for advanced NSCLC patients and its inhibition may improve chemosensitization in NSCLC treatment.
These results showed that high levels of Rab25 expression were significantly correlated with renal cell carcinoma (show MOK Antibodies) invasion classification (P < 0.01), lymph-node metastasis (P < 0.001), and pathological stage (P < 0.01).
High RAB25 expression is associated with good clinical outcome in patients with locally advanced head and neck squamous cell carcinoma.
the crystal structure of Rab25 in complex with the C-terminal region of FIP2 (show OPTN Antibodies), which consists of a central dimeric FIP2 (show OPTN Antibodies) coiled-coil that mediates a heterotetrameric Rab25-(FIP2 (show OPTN Antibodies))2-Rab25 complex.
Overexpression of Rab25 contributes to metastasis of bladder cancer through induction of epithelial-mesenchymal transition and activation of Akt (show AKT1 Antibodies)/GSK-3beta (show GSK3b Antibodies)/Snail (show SNAI1 Antibodies) signaling.
These findings suggest that Rab25 plays an important role in tumor migration and metastasis, and that understanding its function may lead to the development of new strategies to prevent metastasis in oral cancer patients.
Rab25 controls intestinal cell polarity through the regulation of gene expression
RAB25 has been implicated in various cancers, with reports presenting it as both an oncogene (show RAB1A Antibodies) and a tumour-suppressor gene. [Review]
a Grhl2 (show GRHL2 Antibodies)/Ovol2 (show OVOL2 Antibodies) network controls Cldn4 (show CLDN4 Antibodies) and Rab25 expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia
tight regulation of CCN3 (show NOV Antibodies) expression is necessary for normal cortical neuronal connectivity during development, and RAB25 negatively regulates neuronal differentiation as a downstream effector of CCN3 (show NOV Antibodies)
the results indicate that Grhl2 (show GRHL2 Antibodies) regulates epithelial morphogenesis through transcriptional up-regulation of Cldn3 (show CLDN3 Antibodies) and Cldn4 (show CLDN4 Antibodies), as well as of Rab25, which increases the Cldn4 (show CLDN4 Antibodies) protein and its localization at TJs
Rab25 may function as a tumor suppressor in intestinal epithelial cells through regulation of protein trafficking to the cell surface.
RAB proteins, such as RAB25, are members of the RAS superfamily of small GTPases that are involved in membrane trafficking. Members of the RAB11 subfamily, including RAB25, control the return of internalized membrane-associated moieties to the cell surface (Caswell et al., 2007
RAB25, member RAS oncogene family
, ras-related protein Rab-25
, Ras-related protein Rab-25
, small GTP-binding protein