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RAB proteins, such as RAB25, are members of the RAS superfamily of small GTPases that are involved in membrane trafficking. Additionally we are shipping RAB25 Antibodies (69) and many more products for this protein.
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Rab25 may act as a tumor promoter.
Rab25 was upregulated in hepatocellular carcinoma tissues and cells compared with normal liver tissues and cell lines. Rab25 overexpression correlated with advanced tumor stage and nodal metastasis.Rab25 depletion blocked cell growth rate, inhibited colony formation, downregulated AKT (show AKT1 Proteins) phosphorylation, inhibited the Wnt (show WNT2 Proteins) signaling pathway and its target genes, and negatively regulated the invading ability of HCC (show FAM126A Proteins) cells.
Data show that both rab G-Protein RAB25 and RNA-binding protein ESRP1 were suppressed by transcription factor ZEB1, which was in turn regulated via epigenetic mechanisms.
Rab25 expression is a potential prognostic index for advanced NSCLC patients and its inhibition may improve chemosensitization in NSCLC treatment.
These results showed that high levels of Rab25 expression were significantly correlated with renal cell carcinoma (show MOK Proteins) invasion classification (P < 0.01), lymph-node metastasis (P < 0.001), and pathological stage (P < 0.01).
High RAB25 expression is associated with good clinical outcome in patients with locally advanced head and neck squamous cell carcinoma.
the crystal structure of Rab25 in complex with the C-terminal region of FIP2 (show OPTN Proteins), which consists of a central dimeric FIP2 (show OPTN Proteins) coiled-coil that mediates a heterotetrameric Rab25-(FIP2 (show OPTN Proteins))2-Rab25 complex.
Overexpression of Rab25 contributes to metastasis of bladder cancer through induction of epithelial-mesenchymal transition and activation of Akt (show AKT1 Proteins)/GSK-3beta/Snail (show SNAI1 Proteins) signaling.
These findings suggest that Rab25 plays an important role in tumor migration and metastasis, and that understanding its function may lead to the development of new strategies to prevent metastasis in oral cancer patients.
Rab25 controls intestinal cell polarity through the regulation of gene expression
a Grhl2 (show GRHL2 Proteins)/Ovol2 (show OVOL2 Proteins) network controls Cldn4 (show CLDN4 Proteins) and Rab25 expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia
tight regulation of CCN3 (show NOV Proteins) expression is necessary for normal cortical neuronal connectivity during development, and RAB25 negatively regulates neuronal differentiation as a downstream effector of CCN3 (show NOV Proteins)
the results indicate that Grhl2 (show GRHL2 Proteins) regulates epithelial morphogenesis through transcriptional up-regulation of Cldn3 (show CLDN3 Proteins) and Cldn4 (show CLDN4 Proteins), as well as of Rab25, which increases the Cldn4 (show CLDN4 Proteins) protein and its localization at TJs
Rab25 may function as a tumor suppressor in intestinal epithelial cells through regulation of protein trafficking to the cell surface.
RAB proteins, such as RAB25, are members of the RAS superfamily of small GTPases that are involved in membrane trafficking. Members of the RAB11 subfamily, including RAB25, control the return of internalized membrane-associated moieties to the cell surface (Caswell et al., 2007
RAB25, member RAS oncogene family
, ras-related protein Rab-25
, Ras-related protein Rab-25
, small GTP-binding protein