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Small GTP-binding proteins of the RAB family, such as RAB31, play essential roles in vesicle and granule targeting (Bao et al., 2002 [PubMed 11784320]).[supplied by OMIM, Jul 2009].. Additionally we are shipping RAB31 Antibodies (34) and many more products for this protein.
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Human RAB31 Protein expressed in Escherichia coli (E. coli) - ABIN1098265
Rodriguez-Gabin, Cammer, Almazan, Charron, Larocca: Role of rRAB22b, an oligodendrocyte protein, in regulation of transport of vesicles from trans Golgi to endocytic compartments. in Journal of neuroscience research 2001
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this study provides the evidence of Rab31 overexpression in HCC (show FAM126A Proteins), and Rab31 is potentially used as a novel biomarker of poor prognosis in patients with HCC (show FAM126A Proteins). PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins)/Bcl-2 (show BCL2 Proteins)/BAX (show BAX Proteins) axis was involved in Rab31-promoting HCC (show FAM126A Proteins) progression.
Data indicate that early endosome antigen 1 (EEA1 (show EEA1 Proteins)) is important for the small GTPase (show RACGAP1 Proteins) Rab31-mediated enhancement of ligand-bound EGF receptor (EGFR (show EGFR Proteins)) endocytic trafficking.
MUC1 (show MUC1 Proteins)-C and Rab31 function in an autoinductive loop that contributes to overexpression of MUC1 (show MUC1 Proteins)-C in breast cancer cells.
Overexpression of rab31 in breast cancer cells leads to a switch from an invasive to a proliferative phenotype as indicated by an increased cell proliferation, reduced adhesion and invasion in vitro, and a reduced capacity to form lung metastases in vivo.
Neither UPARwt, nor UPAR (show PLAUR Proteins)-del4/5 nor RAB31 mRNA expression levels were found to be prognostic markers in advanced ovarian cancer.
RIN3 (show RIN3 Proteins) specifically acts as a GEF (show SLC2A4RG Proteins) for Rab31.
Thus, Rab22B may have a role in anterograde exit from the trans-Golgi network .
uPAR (show PLAUR Proteins)-del4/5 and rab31 mRNA represent independent prognostic markers in breast cancer and may be components of different, but possibly associated, tumor-relevant signaling pathways.
Rab22B possibly plays role in regulating e (show NES Proteins)pidermal growth factor receptor (EGFR) and mannose 6-phosphate receptor (M6PR) transport into late endosomes.
Rab31, with APPL2 (show APPL2 Proteins) as its effector, play a role in FcgammaR-mediated phagocytosis through PI3K/Akt (show AKT1 Proteins) signaling in macrophages.
a previously unrecognised role for Rab31 in influencing the differentiation and fate of neural progenitor cells
Insulin (show INS Proteins) recruits the CIP4/Gapex-5 (show GAPVD1 Proteins) complex to the plasma membrane, thus reducing Rab31 activity and permitting Glut4 (show SLC2A4 Proteins) vesicles to translocate to the cell surface, where Glut4 (show SLC2A4 Proteins) docks and fuses to transport glucose into the cell.
Rab22B is exceptionally enriched in nestin (show NES Proteins) and RC2-positive radial glia of the embryonic mouse brain. In the adult brain, Rab22B is rather specifically expressed in glial fibrillary acidic protein (GFAP (show GFAP Proteins))-positive mature astrocytes.
Small GTP-binding proteins of the RAB family, such as RAB31, play essential roles in vesicle and granule targeting (Bao et al., 2002
RAB31, member RAS oncogene family
, ras-related protein Rab-31
, ras-related protein Rab-22B
, GTP-binding protein Rab0
, monomeric GTP-binding protein