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RAB39B encodes a member of the Rab family of proteins. Additionally we are shipping RAB39B Proteins (6) and many more products for this protein.
Showing 10 out of 42 products:
Cow (Bovine) Polyclonal RAB39B Primary Antibody for WB - ABIN2785291
Mehrle, Rosenfelder, Schupp, del Val, Arlt, Hahne, Bechtel, Simpson, Hofmann, Hide, Glatting, Huber, Pepperkok, Poustka, Wiemann: The LIFEdb database in 2006. in Nucleic acids research 2005
Human Polyclonal RAB39B Primary Antibody for IF, IHC - ABIN4348927
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
RAB39B mutations are a rare finding in Parkinson disease patients
RAB39B is an essential regulator of vesicular-trafficking in clinically typical Parkinson's disease
RAB39B selectively regulates GluA2 (show GRIA2 Antibodies) trafficking to determine synaptic AMPAR composition
The loss of RAB39B results in dysregulation of alpha-synuclein (show SNCA Antibodies) homeostasis and a spectrum of neuropathological features that implicate RAB39B in the pathogenesis of Parkinson disease and potentially other neurodegenerative disorders.
increased dosage of RAB39B causes a disturbed neuronal development leading to cognitive impairment
Data indicate that myosin Va (show MYO5A Antibodies) interacted with multiple new Rab (show HRB Antibodies) subfamilies including Rab6 (show RAB6A Antibodies), Rab14 (show RAB14 Antibodies) and Rab39B.
These results demonstrate developmental and functional neuronal alteration as a consequence of downregulation of RAB39B and emphasize the critical role of vesicular trafficking in the development of neurons and human intellectual abilities.
RAB39B was expressed in a variety of human tissues and located in human chromosome Xq28.
This gene encodes a member of the Rab family of proteins. Rab proteins are small GTPases that are involved in vesicular trafficking.
RAB39B, member RAS oncogene family
, ras-related protein Rab-39B-like
, ras-related protein Rab-39B