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RAB8A, Member RAS Oncogene Family Proteins (RAB8A)

The protein encoded by RAB8A is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. Additionally we are shipping RAB8A Antibodies (62) and RAB8A Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RAB8A 4218 P61006
RAB8A 17274 P55258
RAB8A 117103 P35280
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Top RAB8A Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 9 to 11 Days
$242.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,498.83
Details
Yeast Dog His tag   1 mg Log in to see 56 to 66 Days
$2,498.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,498.83
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$2,498.83
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,498.83
Details

RAB8A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced RAB8A Proteins

  1. Human RAB8A Protein expressed in Escherichia coli (E. coli) - ABIN1047596 : Nimmo, Sanders, Padua, Hughes, Williamson, Johnson: The MEL gene: a new member of the RAB/YPT class of RAS-related genes. in Oncogene 1991 (PubMed)
    Show all 2 references for ABIN1047596

More Proteins for RAB8A, Member RAS Oncogene Family (RAB8A) Interaction Partners

Human RAB8A, Member RAS Oncogene Family (RAB8A) interaction partners

  1. Data demonstrate that EHBP1L1 links Rab8 and the Bin1 (show BIN1 Proteins)-dynamin (show DNM1 Proteins) complex, which generates membrane curvature and excises the vesicle at the endocytic recycling compartment for apical transport.

  2. Further exploration of the NINL-associated interactome identifies MICAL3 (show MICAL3 Proteins), a protein known to interact with Rab8 and to play an important role in vesicle docking and fusion.

  3. The small GTPase (show RACGAP1 Proteins) Rab8 interacts with VAMP-3 (show VAMP3 Proteins) to regulate the delivery of recycling T-cell receptors to the immune synapse.

  4. the role of Rabin8 (a mammalian ortholog of Sec2p) with Rab8-nucleotide-exchange factor activity in autophagy in mammalian cells, was examined.

  5. DLC3 (show STARD8 Proteins) is recruited to Rab8-positive membrane tubules and is required for the integrity of the Rab8 and Golgi compartments.

  6. Rab8A GTPase (show RACGAP1 Proteins) Ser (show SIGLEC1 Proteins)(111) phosphorylation is not directly regulated by PINK1 (show PINK1 Proteins) in vitro and demonstrate in cells the time course of Ser (show SIGLEC1 Proteins)(111) phosphorylation of Rab8A, 8B and 13 is markedly delayed compared to phosphorylation of Parkin (show PARK2 Proteins) at Ser (show SIGLEC1 Proteins)(65).

  7. Intercellular transfer of transferrin receptor by a contact-, Rab8-dependent mechanism involving tunneling nanotubes.

  8. High expression of RAB8A is associated with endometrial cancer.

  9. Study established a direct interaction between alpha-synclein and Rab8a and provided unique insights into the molecular mechanisms of alpha-synclein toxicity

  10. Rab8a and Drebrin E (show DBN1 Proteins) act as key proteins in the regulation of apical trafficking in intestinal epithelial cells.

Zebrafish RAB8A, Member RAS Oncogene Family (RAB8A) interaction partners

  1. Cc2d2a, localized at the photoreceptor connecting cilium/transition zone, facilitates protein transport through a role in Rab8-dependent vesicle trafficking and fusion.

  2. Data show that elipsa (show TRAF3IP1 Proteins) encodes a coiled-coil polypeptide that localizes to cilia, and that it interacts genetically with Rabaptin5, a well-studied regulator of endocytosis, which in turn interacts with Rab8, a small GTPase (show RACGAP1 Proteins), known to localize to cilia.

Mouse (Murine) RAB8A, Member RAS Oncogene Family (RAB8A) interaction partners

  1. Data demonstrate that EHBP1L1 links Rab8 and the Bin1 (show BIN1 Proteins)-dynamin (show DNM1 Proteins) complex, which generates membrane curvature and excises the vesicle at the endocytic recycling compartment for apical transport.

  2. The small GTPase (show RACGAP1 Proteins) Rab8 interacts with VAMP-3 (show VAMP3 Proteins) to regulate the delivery of recycling T-cell receptors to the immune synapse.

  3. Rab8a thus controls Wnt (show WNT2 Proteins) delivery in producing cells and is crucial for Paneth cell maturation.

  4. Rab8a acts as an activator of Fsp27 (show CIDEC Proteins)-mediated LD fusion and growth.

  5. Simultaneous loss of Rab8a and Rab8b (show RAB8B Proteins) has little effect on ciliogenesis, whereas additional loss of Rab10 (show RAB10 Proteins) greatly affects ciliogenesis.

  6. acidosis-induced NBCe1 (show SLC4A4 Proteins)-A, but not NBCe1 (show SLC4A4 Proteins)-B/C, trafficking is mediated by Rab8a.

  7. AS160 (show TBC1D4 Proteins) and Rab8a regulate membrane recruitment of CD36 (show CD36 Proteins).

  8. Cdc42 (show CDC42 Proteins) and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice

  9. Rab8a colocalizes with IL-1b (show IL1B Proteins) and LC3 (show MAP1LC3A Proteins) and controls IL-1b (show IL1B Proteins) secretion

  10. Rab13 (show RAB13 Proteins) and Rab8A are Rab (show HRB Proteins)-GTPases activated by insulin (show INS Proteins) and downstream of AS160 (show TBC1D4 Proteins) they regulate traffic of GLUT4 (show SLC2A4 Proteins) vesicles.

RAB8A Protein Profile

Protein Summary

The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.

Gene names and symbols associated with RAB8A

  • rab8A protein (rab8A)
  • Rab GTPase (rab8A)
  • RAB8A, member RAS oncogene family (RAB8A)
  • RAB8A, member RAS oncogene family (rab8a)
  • RAB8A, member RAS oncogene family (Rab8a)
  • AA409338 protein
  • c-mel protein
  • DDBDRAFT_0206521 protein
  • DDBDRAFT_0214885 protein
  • DDB_0206521 protein
  • DDB_0214885 protein
  • HSH2D protein
  • Mel protein
  • Rab8 protein
  • rab8A protein
  • zgc:162699 protein

Protein level used designations for RAB8A

rab8A protein , hematopoietic SH2 domain containing , ras-related protein Rab-8A , RAB8A, member RAS oncogene family , member RAS oncogene family , Ras-related protein Rab-8A , mel transforming oncogene (RAB8 homolog) , mel transforming oncogene (derived from cell line NK14) , mel transforming oncogene (derived from cell line NK14)- RAB8 homolog , oncogene c-mel , ras-associated protein RAB8 , RAB8, member RAS oncogene family , cell line NK14 derived transforming oncogene

GENE ID SPECIES
553899 Lotus japonicus
8622514 Dictyostelium discoideum AX4
468760 Pan troglodytes
100125217 Xenopus (Silurana) tropicalis
100380328 Salmo salar
4218 Homo sapiens
403773 Canis lupus familiaris
100125881 Bos taurus
571897 Danio rerio
100037230 Xenopus laevis
428352 Gallus gallus
17274 Mus musculus
117103 Rattus norvegicus
100174026 Pongo abelii
101092668 Felis catus
100511006 Sus scrofa
100302063 Ovis aries
100734132 Cavia porcellus
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