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anti-RAD17 Homolog (S. Pombe) (RAD17) Antibodies

The protein encoded by RAD17 is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. Additionally we are shipping RAD17 Homolog (S. Pombe) Kits (5) and RAD17 Homolog (S. Pombe) Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RAD17 5884 O75943
RAD17 19356 Q6NXW6
RAD17 310034  
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Top anti-RAD17 Homolog (S. Pombe) Antibodies at antibodies-online.com

Showing 10 out of 153 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, WB RAD17 Antibody (Center) (ABIN655646) western blot analysis in A549 cell line lysates (35 µg/lane). This demonstrates the RAD17 antibody detected the RAD17 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, FACS, WB Flow cytometric analysis of A549 cells using  RAD17 Antibody  (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Western blot analysis of RAD17 Antibody  in A549 cell line lysates (35ug/lane). This demonstrates the RAD17 antibody detected the RAD17 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-RAD17 Antibody Titration: 1.25ug/mlELISA Titer: 1:62500Positive Control: Jurkat cell lysate WB Suggested Anti-RAD17 Antibody  Positive Control: Lane1:241 µg Hela lysate, Lane2: 541 µg HEK293T lysate, Lane3: 541 µg Xenopus laevis egg extract, Lane4: 541 µg mouse embryonic stem cells lysate Primary Antibody Dilution: 1:500Secondary Antibody: Anti-rabbit-HRP Secondry  Antibody Dilution: 1:5000Submitted by: Domenico Maiorano, Institute of Human Genetics, CNRS 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$775.50
Details
Human Mouse Un-conjugated WB RAD17 monoclonal antibody (M01), clone 2G12 Western Blot analysis of RAD17 expression in HeLa NE. Detection limit for recombinant GST tagged RAD17 is approximately 1 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of Rad 17 expression in Lysates from  Jurkat cells (Lane 1, 2), 3T3 cells (Lane 3) and rat kidney (Lane 4). 100 μg Log in to see 2 to 3 Days
$283.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-RAD17 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: OVCAR-3 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IF, IHC (p), IP, WB 0.1 mg Log in to see 6 to 8 Days
$368.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HeLa cells treated with UV 15', using RAD17 (Phospho-Ser645) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB WB Image Sample A: 30 ug of 293T nuclear extract 7.5% SDS PAGE antibody diluted at 1:500 100 μL Log in to see 2 to 3 Days
$358.60
Details

RAD17 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-RAD17 Homolog (S. Pombe) Antibodies

  1. Human Polyclonal RAD17 Primary Antibody for EIA, FACS - ABIN954430 : Zhang, Park, Wu, Kim, Liu, Fujita, Balasubramani, Schreiber, Wang, Wan: Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress. in The EMBO journal 2010 (PubMed)
    Show all 5 references for ABIN954430

  2. Human Monoclonal RAD17 Primary Antibody for WB - ABIN393621 : Sowa, Bennett, Gygi, Harper: Defining the human deubiquitinating enzyme interaction landscape. in Cell 2009 (PubMed)
    Show all 5 references for ABIN393621

  3. Human Polyclonal RAD17 Primary Antibody for FACS, WB - ABIN655646 : Vega, Salas, Milne, Carracedo, Ribas, Ruibal, de León, González-Hernández, Benítez, Carracedo: Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. in Gynecologic oncology 2008 (PubMed)
    Show all 2 references for ABIN655646

  4. Cow (Bovine) Polyclonal RAD17 Primary Antibody for WB - ABIN2779300 : Tsao, Geisen, Abraham: Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. in The EMBO journal 2004 (PubMed)

  5. Human Polyclonal RAD17 Primary Antibody for WB - ABIN319084 : Post, Weng, Cimprich, Chen, Xu, Lee: Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage. in Proceedings of the National Academy of Sciences of the United States of America 2001 (PubMed)

More Antibodies against RAD17 Homolog (S. Pombe) Interaction Partners

Arabidopsis thaliana RAD17 Homolog (S. Pombe) (RAD17) interaction partners

  1. a mutant Rad17 pathway is associated with a general deregulation of DNA repair, which seems to be correlated with a deficiency in non-homologous double strand break repair.

Human RAD17 Homolog (S. Pombe) (RAD17) interaction partners

  1. Authors show that BRCA1 and RAD17 genes, whose derived proteins play a pivotal role in DNA damage repair, are transcriptional targets of gain-of-function mutant p53 (show TP53 Antibodies) proteins.

  2. USP20 (show USP20 Antibodies) and Rad17 interact, and that this interaction is enhanced by UV exposure. We show that USP20 (show USP20 Antibodies) regulation of Rad17 is at the protein level in a proteasome-dependent manner. USP20 (show USP20 Antibodies) depletion results in poor activation of Chk1 (show CHEK1 Antibodies) protein by phosphorylation

  3. These data suggest that v-Src (show SRC Antibodies) attenuates ATR (show ANTXR1 Antibodies)-Chk1 (show CHEK1 Antibodies) signaling through the inhibition of Rad17-Rad9 (show RAD9A Antibodies) interaction.

  4. Rad17 is phosphorylated by ATM (show ATM Antibodies) at Thr622 resulting in a direct interaction of Rad17 with NBS1 (show NBN Antibodies), facilitating recruitment of MRE11 (show MRE11A Antibodies), RAD50 (show RAD50 Antibodies) and ATM (show ATM Antibodies) to the DNA double-strand breaks.

  5. Our data suggest RAD17 as a novel target protein for gemcitabine combination therapy supplementing or complementing inhibition of CHK1 (show CHEK1 Antibodies).

  6. Knockdown of Rad17 with two independent siRNAs significantly reduced Chk1 (show CHEK1 Antibodies) phosphorylation and substantial RPA32 (show RPA2 Antibodies) Ser33 phosphorylation.

  7. Data indicate that regulation of Rad17 turnover is through the Cdh1 (show CDH1 Antibodies)/anaphase-promoting complex pathway in breast cancer cells.

  8. Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance.

  9. Proteolysis of Rad17 by Cdh1 (show CDH1 Antibodies)/APC (show APC Antibodies) regulates checkpoint termination and recovery from genotoxic stress

  10. upon replication block a Rad17/RF-C complex is recruited to sites of DNA lesions in late S phase, binds the Rad9 (show RAD9A Antibodies)/Hus1 (show HUS1 Antibodies)/Rad1 (show ERCC4 Antibodies) complex and enables it to interact with PCNA (show PCNA Antibodies). An interaction of Rad17/RF-C with PCNA (show PCNA Antibodies) is mediated by the small RF-C p37 (show CCNH Antibodies) subunit

Mouse (Murine) RAD17 Homolog (S. Pombe) (RAD17) interaction partners

  1. targeted deletion of an N-terminal part of mRad17, the mouse homolog of the Schizosaccharomyces pombe Rad17 checkpoint clamp-loader component, resulted in embryonic lethality during early/mid-gestation

RAD17 Homolog (S. Pombe) (RAD17) Antigen Profile

Protein Summary

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.

Gene names and symbols associated with RAD17

  • RAD17 homolog (S. pombe) (RAD17) antibody
  • RAD17 homolog (S. pombe) (rad17) antibody
  • Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins (RAD17) antibody
  • cell cycle checkpoint protein RAD17 (ATRAD17) antibody
  • RAD17 homolog (S. pombe) (Rad17) antibody
  • 9430035O09Rik antibody
  • CCYC antibody
  • HRAD17 antibody
  • K2A18.21 antibody
  • K2A18_21 antibody
  • MmRad24 antibody
  • R24L antibody
  • RAD17 antibody
  • RAD17SP antibody
  • RAD24 antibody
  • RADIATION SENSITIVE 17 antibody
  • zgc:91969 antibody

Protein level used designations for RAD17

RAD17 homolog (S. pombe) , cell cycle checkpoint protein RAD17-like , cell cycle checkpoint protein RAD17 , Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins , Rad17p , RAD17 homolog , Cell cycle checkpoint protein RAD17 , RAD1 homolog , RF-C activator 1 homolog , RF-C/activator 1 homolog , Rad17-like protein , cell cycle checkpoint protein (RAD17)

GENE ID SPECIES
100081629 Ornithorhynchus anatinus
100339735 Oryctolagus cuniculus
100385537 Callithrix jacchus
100464145 Ailuropoda melanoleuca
436934 Danio rerio
854550 Saccharomyces cerevisiae S288c
100190842 Pongo abelii
836745 Arabidopsis thaliana
5884 Homo sapiens
19356 Mus musculus
478088 Canis lupus familiaris
513600 Bos taurus
310034 Rattus norvegicus
100065769 Equus caballus
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