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The protein encoded by RAD17 is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. Additionally we are shipping RAD17 Homolog (S. Pombe) Kits (5) and RAD17 Homolog (S. Pombe) Proteins (4) and many more products for this protein.
Showing 10 out of 186 products:
Human Polyclonal RAD17 Primary Antibody for EIA, FACS - ABIN954430
Zhang, Park, Wu, Kim, Liu, Fujita, Balasubramani, Schreiber, Wang, Wan: Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress. in The EMBO journal 2010
Show all 5 references for ABIN954430
Human Monoclonal RAD17 Primary Antibody for WB - ABIN393621
Sowa, Bennett, Gygi, Harper: Defining the human deubiquitinating enzyme interaction landscape. in Cell 2009
Show all 5 references for ABIN393621
Human Polyclonal RAD17 Primary Antibody for FACS, WB - ABIN655646
Vega, Salas, Milne, Carracedo, Ribas, Ruibal, de León, González-Hernández, Benítez, Carracedo: Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. in Gynecologic oncology 2008
Show all 2 references for ABIN655646
Cow (Bovine) Polyclonal RAD17 Primary Antibody for WB - ABIN2779300
Tsao, Geisen, Abraham: Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. in The EMBO journal 2004
Human Polyclonal RAD17 Primary Antibody for WB - ABIN319084
Post, Weng, Cimprich, Chen, Xu, Lee: Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage. in Proceedings of the National Academy of Sciences of the United States of America 2001
a mutant Rad17 pathway is associated with a general deregulation of DNA repair, which seems to be correlated with a deficiency in non-homologous double strand break repair.
Authors show that BRCA1 and RAD17 genes, whose derived proteins play a pivotal role in DNA damage repair, are transcriptional targets of gain-of-function mutant p53 (show TP53 Antibodies) proteins.
USP20 (show USP20 Antibodies) and Rad17 interact, and that this interaction is enhanced by UV exposure. We show that USP20 (show USP20 Antibodies) regulation of Rad17 is at the protein level in a proteasome-dependent manner. USP20 (show USP20 Antibodies) depletion results in poor activation of Chk1 (show CHEK1 Antibodies) protein by phosphorylation
These data suggest that v-Src (show SRC Antibodies) attenuates ATR (show ANTXR1 Antibodies)-Chk1 (show CHEK1 Antibodies) signaling through the inhibition of Rad17-Rad9 (show RAD9A Antibodies) interaction.
Rad17 is phosphorylated by ATM (show ATM Antibodies) at Thr622 resulting in a direct interaction of Rad17 with NBS1 (show NBN Antibodies), facilitating recruitment of MRE11 (show MRE11A Antibodies), RAD50 (show RAD50 Antibodies) and ATM (show ATM Antibodies) to the DNA double-strand breaks.
Our data suggest RAD17 as a novel target protein for gemcitabine combination therapy supplementing or complementing inhibition of CHK1 (show CHEK1 Antibodies).
Knockdown of Rad17 with two independent siRNAs significantly reduced Chk1 (show CHEK1 Antibodies) phosphorylation and substantial RPA32 (show RPA2 Antibodies) Ser33 phosphorylation.
Data indicate that regulation of Rad17 turnover is through the Cdh1 (show CDH1 Antibodies)/anaphase-promoting complex pathway in breast cancer cells.
Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance.
Proteolysis of Rad17 by Cdh1 (show CDH1 Antibodies)/APC (show APC Antibodies) regulates checkpoint termination and recovery from genotoxic stress
upon replication block a Rad17/RF-C complex is recruited to sites of DNA lesions in late S phase, binds the Rad9 (show RAD9A Antibodies)/Hus1 (show HUS1 Antibodies)/Rad1 (show ERCC4 Antibodies) complex and enables it to interact with PCNA (show PCNA Antibodies). An interaction of Rad17/RF-C with PCNA (show PCNA Antibodies) is mediated by the small RF-C p37 (show CCNH Antibodies) subunit
targeted deletion of an N-terminal part of mRad17, the mouse homolog of the Schizosaccharomyces pombe Rad17 checkpoint clamp-loader component, resulted in embryonic lethality during early/mid-gestation
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.
RAD17 homolog (S. pombe)
, cell cycle checkpoint protein RAD17-like
, cell cycle checkpoint protein RAD17
, Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins
, RAD17 homolog
, Cell cycle checkpoint protein RAD17
, RAD1 homolog
, RF-C activator 1 homolog
, RF-C/activator 1 homolog
, Rad17-like protein
, cell cycle checkpoint protein (RAD17)