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Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Additionally we are shipping RAD51D Antibodies (91) and many more products for this protein.
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Cells deficient in RAD51D (a RAD51 (show RAD51 Proteins) paralogue) are extremely sensitive to 6-thioguanine.
RAD51D protects against MLH1 (show MLH1 Proteins)-dependent cytotoxic responses to O(6)-methylguanine
a fragment of Rad51B (show Rad51B Proteins) containing amino acid residues 1-75 interacts with the C-terminus and linker of Rad51C (show RAD51C Proteins), residues 79-376, and this region of Rad51C (show RAD51C Proteins) also interacts with mRad51D and Xrcc3 (show XRCC3 Proteins)
Findings support a crucial role for mammalian RAD51D in normal development, recombination, and maintaining mammalian genome stability.
These cell-based studies are the first evidence that ATP binding and hydrolysis by RAD51D are required for efficient HR repair of DNA interstrand crosslinks.
Rad51d alternative splice variants potentially modulate mechanisms of homologous recombination by sequestering either RAD51C or XRCC2
Interactions of four candidate proteins (SFPQ, NONO (show NONO Proteins), MSH2 (show MSH2 Proteins) and mini chromosome maintenance protein 2) were confirmed by Western blot analysis of co-precipitation eluates and were also verified to form ex vivo complexes with RAD51D.
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA (By similarity).
DNA repair protein RAD51 homolog 4
, RAD51-like 3