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The protein encoded by RASA3 is member of the GAP1 family of GTPase-activating proteins. Additionally we are shipping RAS P21 Protein Activator 3 Proteins (5) and many more products for this protein.
Showing 10 out of 84 products:
Human Monoclonal RASA3 Primary Antibody for ELISA, WB - ABIN4948249
Kupzig, Bouyoucef-Cherchalli, Yarwood, Sessions, Cullen: The ability of GAP1IP4BP to function as a Rap1 GTPase-activating protein (GAP) requires its Ras GAP-related domain and an arginine finger rather than an asparagine thumb. in Molecular and cellular biology 2009
Show all 5 references for ABIN4948249
Human Polyclonal RASA3 Primary Antibody for ELISA, WB - ABIN1451505
Cullen, Hsuan, Truong, Letcher, Jackson, Dawson, Irvine: Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family. in Nature 1995
Show all 2 references for ABIN1451505
Dog (Canine) Polyclonal RASA3 Primary Antibody for ELISA - ABIN250347
Kuai, Wooters, Hall, Rao, Nickbarg, Li, Chatterjee-Kishore, Qiu, Lin: NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-interacting proteins by a proteomic approach. in The Journal of biological chemistry 2004
these results support an important role for Rasa3 in PI3K (show PIK3CA Antibodies)-dependent integrin alphaIIbbeta3-mediated outside-in signaling and cell spreading.
the function of RASA3 during megakaryopoiesis, megakaryocyte adhesion and migration as well as integrin signaling has been reported.
model in which the Ras GAP (show RASA1 Antibodies)-related domain of GAP1(IP4BP) functions to stabilize the switch II region of Rap1 (show RABGEF1 Antibodies), allowing stabilization of the transition state during GTP (show AK3 Antibodies) hydrolysis initiated by the arginine finger
GAP1IP4BP is an inositol 1,3,4,5-tetrakisphosphate regulated plasma membrane associated Ras and Rap (show LRPAP1 Antibodies) GAP. Membrane association results from its PH domain binding phosphatidylinositol 4,5-bisphosphate.
these results support an important role for Rasa3 in PI3K-dependent integrin alphaIIbbeta3-mediated outside-in signaling and cell spreading.
our results indicate that Rasa3 catalytic activity controls Rap1 activation and integrin signaling during megakaryocyte differentiation in mouse.
Expression of RASA3 led to premature platelet activation and markedly reduced the life span of circulating platelets.
Identified is in the scat (severe combined anemia and thrombocytopenia) mouse model a missense mutation (G125V) in the Rasa3 gene, encoding a Ras GTPase activating protein (show RASA1 Antibodies).
RASA3 plays a critical, conserved, and nonredundant role for RASA3 in vertebrate hematopoiesis.
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane.
RAS p21 protein activator 3
, ras GTPase-activating protein 3-like
, GTPase activating protein III
, Ins(1,3,4,5)P4-binding protein
, inositol 1,3,4,5-tetrakisphosphate-binding protein
, ins P4-binding protein
, ras GTPase-activating protein 3
, GAPIII activator 3
, R-Ras gap
, R-ras RTPase activating protein-3
, Ras GTPase-activating protein III
, Ins P4-binding protein
, R-Ras GTP activating protein
, R-ras GTPase activating protein
, RAS p21 protein activator (GTPase activating protein) 3 (Ins(1,3,4,5)P4-binding protein)