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The protein encoded by RDBP is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. Additionally we are shipping RD RNA Binding Protein Proteins (7) and many more products for this protein.
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Cow (Bovine) Polyclonal RDBP Primary Antibody for WB - ABIN2778822
Rao, Schweimer, Wenzel, Wöhrl, Rösch: NELF-E RRM undergoes major structural changes in flexible protein regions on target RNA binding. in Biochemistry 2008
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biochemical analysis reveals that the sequence-specific transcription factor, GAF, orchestrates efficient pausing by recruiting NELF to promoters before transcription initiation and by assisting in loading NELF onto Pol II after initiation
The finding that both phenotypes of arrested embryos are obtained in embryos that lack maternally provided NELF-A (show WHSC2 Antibodies) as well as in embryos with reduced levels of maternal NELF-E show that these phenotypes result from the reduced activity of the NELF complex.
propose that NELF and DSIF (show SUPT4H1 Antibodies) cause polymerase to pause in the promoter proximal region of hsp70
novel actions of BRD4 (show BRD4 Antibodies) and of NELF-E in GR-controlled gene induction have been uncovered.
Following NELF-E knockdown or tumor necrosis factor alpha stimulation, promoter-proximal RNAP II levels increase up to 3-fold, and there is a dramatic increase in RNAP II levels within the HIV genome.
these results describe the RNA binding behavior of NELF-E and supports a biological role for NELF-E in promoter-proximal pausing of both HIV-1 and cellular genes.
Multivariate analysis revealed that RDBP protein levels were an independent risk factor for early intrahepatic recurrence of HCC (show FAM126A Antibodies) within 2 years of surgery.
the transcription elongation of KSHV OriLytL-K7 lytic genes is inhibited by NELF (show NELF Antibodies) during latency, but can also be promptly reactivated in an RTA (show RBM9 Antibodies)-independent manner upon external stimuli
data show that NELF (show NELF Antibodies) subunits exhibit highly specific subcellular localizations, such as in NELF (show NELF Antibodies) bodies or in midbodies, and some shuttle actively between the nucleus and cytoplasm; loss of NELF (show NELF Antibodies) from cells can lead to enlarged and/or multiple nuclei
Transient NELF-E knock-down in pituitary increased coincidentally prolactin (show PRL Antibodies) expression and enhanced transcription of a prolactin (show PRL Antibodies)-promoter reporter gene.
Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA
NELF-C (show TH1L Antibodies) and NELF-D (show TH1L Antibodies) are highly related or identical to the protein called TH1 (show TH1L Antibodies), of unknown function. NELF-B (show COBRA1 Antibodies) and NELF-C (show TH1L Antibodies) or NELF-D (show TH1L Antibodies) are integral subunits that bring NELF-A (show WHSC2 Antibodies) and NELF-E together. [NELF-B (show COBRA1 Antibodies)] [NELF-C (show TH1L Antibodies)]
5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity-inducing factor (DSIF (show SUPT5H Antibodies))- and NELF (show NELF Antibodies)-mediated transcriptional pausing has a dual function in regulating immediate-early (show JUN Antibodies) expression of the human junB (show JUNB Antibodies) gene.
The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins\; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.
, negative elongation factor
, negative elongation factor E
, RD RNA binding protein
, RD RNA-binding protein
, RNA-binding protein RD
, major histocompatibility complex gene RD
, negative elongation factor polypeptide E
, nuclear protein